Entity Details

Primary name IL21R
Entity type gene
Source Source Link

Details

PrimaryID50615
RefseqGeneNG_012222
SymbolIL21R
Nameinterleukin 21 receptor
Chromosome16
Location16p12.1
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2000-03-31
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsIL21R_HUMAN

GO terms

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GOName
GO:0001532 interleukin-21 receptor activity
GO:0004888 transmembrane signaling receptor activity
GO:0004896 cytokine receptor activity
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0030101 natural killer cell activation
GO:0038114 interleukin-21-mediated signaling pathway

Diseases

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Disease IDSourceNameDescription
615207 OMIMImmunodeficiency 56 (IMD56)An autosomal recessive primary immunodeficiency characterized by B- and T-cell defects and variable dysfunction of NK cells. Patients tend to have normal numbers of lymphocytes, but show defective class-switched B-cells, low IgG, defective antibody response, and defective T-cell responses to certain antigens. The disease is caused by variants affecting the gene represented in this entry.

Interactions

5 interactions

InteractorPartnerSourcesPublicationsLink
IL21RAQP1BioGRID, IntAct32296183 details
IL21RJAK1BioGRID, HPRD11016959 11418623 details
IL21RWSB2BioGRID20059963 details
IL21RIL21HPRD11418623 details
IL21RSMARCA2BioGRID31753913 details