Entity Details

Primary name PAK3
Entity type gene
Source Source Link

Details

PrimaryID5063
RefseqGeneNG_008288
SymbolPAK3
Namep21 (RAC1) activated kinase 3
ChromosomeX
LocationXq23
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-03-25
ModificationDate2021-06-22

Ontological Relatives

UniProt IDsPAK3_HUMAN

GO terms

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GOName
GO:0002223 stimulatory C-type lectin receptor signaling pathway
GO:0004674 protein serine/threonine kinase activity
GO:0004708 MAP kinase kinase activity
GO:0005524 ATP binding
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0007409 axonogenesis
GO:0010763 positive regulation of fibroblast migration
GO:0014069 postsynaptic density
GO:0016358 dendrite development
GO:0017124 SH3 domain binding
GO:0030833 regulation of actin filament polymerization
GO:0031098 stress-activated protein kinase signaling cascade
GO:0031267 small GTPase binding
GO:0031295 T cell costimulation
GO:0032147 activation of protein kinase activity
GO:0043525 positive regulation of neuron apoptotic process
GO:0046872 metal ion binding
GO:0048013 ephrin receptor signaling pathway
GO:0050770 regulation of axonogenesis
GO:0050808 synapse organization
GO:0050852 T cell receptor signaling pathway
GO:0060997 dendritic spine morphogenesis
GO:0061003 positive regulation of dendritic spine morphogenesis
GO:0071407 cellular response to organic cyclic compound
GO:0098978 glutamatergic synapse
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:2000573 positive regulation of DNA biosynthetic process

Diseases

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Disease IDSourceNameDescription
300558 OMIMMental retardation, X-linked 30 (MRX30)A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. Intellectual deficiency is the only primary symptom of non-syndromic X-linked mental retardation, while syndromic mental retardation presents with associated physical, neurological and/or psychiatric manifestations. The disease is caused by variants affecting the gene represented in this entry.