Entity Details

Primary name M3K11_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ16584
EntryNameM3K11_HUMAN
FullNameMitogen-activated protein kinase kinase kinase 11
TaxID9606
Evidenceevidence at protein level
Length847
SequenceStatuscomplete
DateCreated2005-07-19
DateModified2021-06-02

Ontological Relatives

GenesMAP3K11

GO terms

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GOName
GO:0000187 obsolete activation of MAPK activity
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004706 JUN kinase kinase kinase activity
GO:0005524 ATP binding
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005874 microtubule
GO:0006468 protein phosphorylation
GO:0007017 microtubule-based process
GO:0007254 JNK cascade
GO:0007257 obsolete activation of JUN kinase activity
GO:0008219 cell death
GO:0016020 membrane
GO:0031267 small GTPase binding
GO:0031434 mitogen-activated protein kinase kinase binding
GO:0031435 mitogen-activated protein kinase kinase kinase binding
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043065 positive regulation of apoptotic process
GO:0043507 positive regulation of JUN kinase activity
GO:0043525 positive regulation of neuron apoptotic process
GO:0044843 cell cycle G1/S phase transition
GO:0046330 positive regulation of JNK cascade
GO:0046777 protein autophosphorylation
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR001452 SH3 domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR016231 Mitogen-activated protein (MAP) kinase kinase kinase, MLK1-4FamilyFamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR035779 MLK1-3, SH3 domainDomainDomain
IPR036028 SH3-like domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB12010 FostamatinibDrugbanksmall molecule

Interactions

38 interactions

InteractorPartnerSourcesPublicationsLink
M3K11_HUMANCLC4G_HUMANBioGRID, IntAct18624398 details
M3K11_HUMANM4K1_HUMANBioGRID, HPRD, MINT11053428 9346925 details
M3K11_HUMANCSN5_HUMANBioGRID, IntAct20936779 details
M3K11_HUMANEPS8_HUMANBioGRID, IntAct21988832 details
M3K11_HUMANPIN1_HUMANBioGRID, IntAct21988832 details
M3K11_HUMANMERL_HUMANI2D20890305 details
M3K11_HUMANCDC42_HUMANBioGRID, HPRD, I2D, IntAct10799501 16253996 20890305 25241761 9427749 details
M3K11_HUMANSH3R1_HUMANBioGRID, HPRD14504284 details
M3K11_HUMANKIF17_HUMANBioGRID9427749 details
M3K11_HUMANKIF3A_HUMANBioGRID, HPRD9427749 details
M3K11_HUMANKIFA3_HUMANBioGRID9427749 details
M3K11_HUMANKIF3B_HUMANBioGRID9427749 details
M3K11_HUMANJIP1_HUMANBioGRID, HPRD10490659 16456539 23172226 details
M3K11_HUMANJIP2_HUMANBioGRID, HPRD10490659 details
M3K11_HUMANRHOG_HUMANBioGRID, HPRD12376551 details
M3K11_HUMANAKT1_HUMANBioGRID, HPRD12458207 details
M3K11_HUMANJIP3_HUMANBioGRID, HPRD10629060 details
M3K11_HUMANIKKB_HUMANBioGRID, HPRD10713178 details
M3K11_HUMANIKKA_HUMANBioGRID, HPRD10713178 details
M3K11_HUMANMP2K4_HUMANBioGRID10187804 details
M3K11_HUMANMP2K7_HUMANBioGRID, HPRD10187804 15001580 details
M3K11_HUMANTRAF6_HUMANBioGRID19586614 23172226 details
M3K11_HUMANA4_HUMANBioGRID12917434 details
M3K11_HUMANCHIP_HUMANBioGRID24912674 details
M3K11_HUMANRAC1_HUMANBioGRID, HPRD9427749 details
M3K11_HUMANM3K21_HUMANBioGRID28757353 details
M3K11_HUMANM4K2_HUMANBioGRID, HPRD, IntAct11784851 details
M3K11_HUMANDLG4_HUMANBioGRID11152698 details
M3K11_HUMANTRAF2_HUMANBioGRID19586614 details
M3K11_HUMANTRIM5_HUMANBioGRID22078707 details
M3K11_HUMANCBL_HUMANBioGRID19546888 details
M3K11_HUMANM3K11_HUMANBioGRID, HPRD11053428 11590155 12376551 23172226 25091198 details
M3K11_HUMANHS90A_HUMANBioGRID15001580 24912674 details
M3K11_HUMANCDC37_HUMANBioGRID15001580 details
M3K11_HUMANHS90B_HUMANBioGRID15001580 details
M3K11_HUMANHSP74_HUMANBioGRID24912674 details
M3K11_HUMANGRIK2_HUMANBioGRID22483987 details
M3K11_HUMANM3K12_HUMANHPRD10187804 details