Entity Details

Primary name INPP5K
Entity type gene
Source Source Link

Details

PrimaryID51763
RefseqGeneNG_029891
SymbolINPP5K
Nameinositol polyphosphate-5-phosphatase K
Chromosome17
Location17p13.3
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2000-05-11
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsINP5K_HUMAN

GO terms

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GOName
GO:0001701 in utero embryonic development
GO:0001726 ruffle
GO:0001933 negative regulation of protein phosphorylation
GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
GO:0004445 inositol-polyphosphate 5-phosphatase activity
GO:0005000 vasopressin receptor activity
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005802 trans-Golgi network
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005979 regulation of glycogen biosynthetic process
GO:0006469 negative regulation of protein kinase activity
GO:0006661 phosphatidylinositol biosynthetic process
GO:0007186 G protein-coupled receptor signaling pathway
GO:0010801 negative regulation of peptidyl-threonine phosphorylation
GO:0010829 negative regulation of glucose transmembrane transport
GO:0016020 membrane
GO:0016311 dephosphorylation
GO:0016312 inositol bisphosphate phosphatase activity
GO:0030036 actin cytoskeleton organization
GO:0032587 ruffle membrane
GO:0032869 cellular response to insulin stimulus
GO:0032870 cellular response to hormone stimulus
GO:0033137 negative regulation of peptidyl-serine phosphorylation
GO:0034485 phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity
GO:0034594 phosphatidylinositol trisphosphate phosphatase activity
GO:0034595 phosphatidylinositol phosphate 5-phosphatase activity
GO:0035305 negative regulation of dephosphorylation
GO:0035810 positive regulation of urine volume
GO:0042577 lipid phosphatase activity
GO:0042593 glucose homeostasis
GO:0043005 neuron projection
GO:0043407 negative regulation of MAP kinase activity
GO:0043922 negative regulation by host of viral transcription
GO:0045719 negative regulation of glycogen biosynthetic process
GO:0045869 negative regulation of single stranded viral RNA replication via double stranded DNA intermediate
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0046030 inositol trisphosphate phosphatase activity
GO:0046627 negative regulation of insulin receptor signaling pathway
GO:0046855 inositol phosphate dephosphorylation
GO:0046856 phosphatidylinositol dephosphorylation
GO:0048471 perinuclear region of cytoplasm
GO:0051497 negative regulation of stress fiber assembly
GO:0051898 negative regulation of protein kinase B signaling
GO:0051926 negative regulation of calcium ion transport
GO:0052658 inositol-1,4,5-trisphosphate 5-phosphatase activity
GO:0052659 inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity
GO:0071320 cellular response to cAMP
GO:0071356 cellular response to tumor necrosis factor
GO:0071364 cellular response to epidermal growth factor stimulus
GO:0072659 protein localization to plasma membrane
GO:0090315 negative regulation of protein targeting to membrane
GO:0097178 ruffle assembly
GO:2000466 negative regulation of glycogen (starch) synthase activity
GO:2001153 positive regulation of renal water transport

Diseases

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Disease IDSourceNameDescription
617404 OMIMMuscular dystrophy, congenital, with cataracts and intellectual disability (MDCCAID)An autosomal recessive form of muscular dystrophy with onset in early childhood and characterized by progressive muscle weakness. Almost all patients also have early-onset cataracts and intellectual disability of varying severity. Some patients have seizures. The disease is caused by variants affecting the gene represented in this entry.

Interactions

53 interactions

InteractorPartnerSourcesPublicationsLink
INPP5KARL6IP1BioGRID, HPRD, IntAct16189514 29892012 32296183 details
INPP5KLNX1IntAct16002321 details
INPP5KBDNFBioGRID, IntAct21988832 details
INPP5KTANKBioGRID, IntAct21988832 details
INPP5KCPTPBioGRID, IntAct21988832 details
INPP5KANXA7BioGRID, MINT21900206 details
INPP5KCDKN1ABioGRID, MINT21900206 details
INPP5KHMOX2BioGRID, MINT21900206 details
INPP5KPFDN1BioGRID, MINT21900206 details
INPP5KSMN1BioGRID, MINT21900206 details
INPP5KSMN2MINT21900206 details
INPP5KTK1BioGRID, MINT21900206 details
INPP5KTTRBioGRID, MINT21900206 details
INPP5KHSPB1BioGRID, IntAct25277244 details
INPP5KMAD2L1BPBioGRID, IntAct25416956 28514442 29892012 32296183 details
INPP5KKRT31BioGRID, IntAct25416956 32296183 details
INPP5KFATE1BioGRID, IntAct25416956 29892012 32296183 details
INPP5KFADS6BioGRID, IntAct32296183 details
INPP5KTNFRSF10DBioGRID, IntAct32296183 details
INPP5KATP5PFBioGRID, IntAct32296183 details
INPP5KGOLT1BBioGRID, IntAct32296183 details
INPP5KSFT2D2BioGRID, IntAct32296183 details
INPP5KKLK6IntAct32814053 details
INPP5KNCOR2BioGRID11509665 details
INPP5KFBXO7BioGRID27503909 details
INPP5KPBX3BioGRID32296183 details
INPP5KEPPK1IntAct17353931 details
INPP5KPDXDC1IntAct17353931 details
INPP5KDCDIntAct17353931 details
INPP5KPYGMIntAct17353931 details
INPP5KBCAR1bhf-ucl28007913 details
INPP5KHSCBBioGRID, IntAct28380382 details
INPP5KPROSER2BioGRID, IntAct28514442 details
INPP5KNTAQ1BioGRID, IntAct28514442 details
INPP5KABHD10BioGRID, IntAct28514442 details
INPP5KUSP47BioGRID, IntAct28514442 details
INPP5KC1orf131BioGRID, IntAct28514442 details
INPP5KRFX1BioGRID, IntAct28514442 details
INPP5KGARTBioGRID, IntAct28514442 details
INPP5KUBBBioGRID, IntAct28514442 details
INPP5KKATNA1BioGRID, IntAct28514442 details
INPP5KPES1BioGRID, IntAct28514442 details
INPP5KNECTIN3BioGRID, IntAct26186194 28514442 details
INPP5KAAMPBioGRID, IntAct26186194 28514442 details
INPP5KRIPK3BioGRID21903422 details
INPP5KGPHA2BioGRID26186194 details
INPP5KHIF1ANBioGRID26972000 details
INPP5KEGLN3BioGRID26972000 details
INPP5KKIF14BioGRID31586073 details
INPP5KBRPF3BioGRID31753913 details
INPP5KFAM20CBioGRID32149426 details
INPP5KMOV10BioGRID22658674 details
INPP5KNXF1BioGRID22658674 details