Entity Details

Primary name TREM2
Entity type gene
Source Source Link

Details

PrimaryID54209
RefseqGeneNG_011561
SymbolTREM2
Nametriggering receptor expressed on myeloid cells 2
Chromosome6
Location6p21.1
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2000-06-10
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsTREM2_HUMAN

GO terms

Show/Hide Table
GOName
GO:0001530 lipopolysaccharide binding
GO:0001540 amyloid-beta binding
GO:0001774 microglial cell activation
GO:0001934 positive regulation of protein phosphorylation
GO:0002282 microglial cell activation involved in immune response
GO:0002588 positive regulation of antigen processing and presentation of peptide antigen via MHC class II
GO:0002931 response to ischemia
GO:0004888 transmembrane signaling receptor activity
GO:0005543 phospholipid binding
GO:0005576 extracellular region
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006911 phagocytosis, engulfment
GO:0006959 humoral immune response
GO:0008035 high-density lipoprotein particle binding
GO:0008289 lipid binding
GO:0010468 regulation of gene expression
GO:0010507 negative regulation of autophagy
GO:0010628 positive regulation of gene expression
GO:0010822 positive regulation of mitochondrion organization
GO:0016021 integral component of membrane
GO:0030169 low-density lipoprotein particle binding
GO:0030316 osteoclast differentiation
GO:0031226 intrinsic component of plasma membrane
GO:0032006 regulation of TOR signaling
GO:0032008 positive regulation of TOR signaling
GO:0032497 detection of lipopolysaccharide
GO:0032499 detection of peptidoglycan
GO:0032675 regulation of interleukin-6 production
GO:0032691 negative regulation of interleukin-1 beta production
GO:0032720 negative regulation of tumor necrosis factor production
GO:0032733 positive regulation of interleukin-10 production
GO:0034185 apolipoprotein binding
GO:0034186 apolipoprotein A-I binding
GO:0034189 very-low-density lipoprotein particle binding
GO:0034241 positive regulation of macrophage fusion
GO:0038023 signaling receptor activity
GO:0042742 defense response to bacterium
GO:0042834 peptidoglycan binding
GO:0043066 negative regulation of apoptotic process
GO:0043277 apoptotic cell clearance
GO:0044853 plasma membrane raft
GO:0044877 protein-containing complex binding
GO:0045087 innate immune response
GO:0045088 regulation of innate immune response
GO:0045672 positive regulation of osteoclast differentiation
GO:0048143 astrocyte activation
GO:0050714 positive regulation of protein secretion
GO:0050730 regulation of peptidyl-tyrosine phosphorylation
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050776 regulation of immune response
GO:0050850 positive regulation of calcium-mediated signaling
GO:0050921 positive regulation of chemotaxis
GO:0060075 regulation of resting membrane potential
GO:0060100 positive regulation of phagocytosis, engulfment
GO:0061518 microglial cell proliferation
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070392 detection of lipoteichoic acid
GO:0070891 lipoteichoic acid binding
GO:0071223 cellular response to lipoteichoic acid
GO:0071224 cellular response to peptidoglycan
GO:0071640 regulation of macrophage inflammatory protein 1 alpha production
GO:0071813 lipoprotein particle binding
GO:0097028 dendritic cell differentiation
GO:0097110 scaffold protein binding
GO:0097242 amyloid-beta clearance
GO:0098657 import into cell
GO:0120035 regulation of plasma membrane bounded cell projection organization
GO:0150062 complement-mediated synapse pruning
GO:0150076 neuroinflammatory response
GO:1900223 positive regulation of amyloid-beta clearance
GO:1901076 positive regulation of engulfment of apoptotic cell
GO:1901224 positive regulation of NIK/NF-kappaB signaling
GO:1901800 positive regulation of proteasomal protein catabolic process
GO:1901980 positive regulation of inward rectifier potassium channel activity
GO:1902531 regulation of intracellular signal transduction
GO:1903078 positive regulation of protein localization to plasma membrane
GO:1903082 positive regulation of C-C chemokine receptor CCR7 signaling pathway
GO:1903980 positive regulation of microglial cell activation
GO:1904093 negative regulation of autophagic cell death
GO:1904141 positive regulation of microglial cell migration
GO:1904646 cellular response to amyloid-beta
GO:1905291 positive regulation of CAMKK-AMPK signaling cascade
GO:1990782 protein tyrosine kinase binding
GO:2000350 positive regulation of CD40 signaling pathway
GO:2001171 positive regulation of ATP biosynthetic process

Diseases

Show/Hide Table
Disease IDSourceNameDescription
618193 OMIMPolycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy 2 (PLOSL2)An autosomal recessive disease characterized by presenile frontal dementia with leukoencephalopathy and basal ganglia calcification. In most cases the disorder first manifests in early adulthood as pain and swelling in ankles and feet, followed by bone fractures. Neurologic symptoms manifest in the fourth decade of life as a frontal lobe syndrome with loss of judgment, euphoria, and disinhibition. Progressive decline in other cognitive domains begins to develop at about the same time. The disorder culminates in a profound dementia and death by age 50 years. The disease is caused by variants affecting the gene represented in this entry.