Entity Details

Primary name WNT4
Entity type gene
Source Source Link

Details

PrimaryID54361
RefseqGeneNG_008974
SymbolWNT4
NameWnt family member 4
Chromosome1
Location1p36.12
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2000-07-12
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsWNT4_HUMAN

GO terms

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GOName
GO:0001658 branching involved in ureteric bud morphogenesis
GO:0001822 kidney development
GO:0001837 epithelial to mesenchymal transition
GO:0001838 embryonic epithelial tube formation
GO:0001889 liver development
GO:0003714 transcription corepressor activity
GO:0005109 frizzled binding
GO:0005125 cytokine activity
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005788 endoplasmic reticulum lumen
GO:0005796 Golgi lumen
GO:0005886 plasma membrane
GO:0008584 male gonad development
GO:0008585 female gonad development
GO:0009267 cellular response to starvation
GO:0009986 cell surface
GO:0010629 negative regulation of gene expression
GO:0010894 negative regulation of steroid biosynthetic process
GO:0016055 Wnt signaling pathway
GO:0022407 regulation of cell-cell adhesion
GO:0030182 neuron differentiation
GO:0030237 female sex determination
GO:0030325 adrenal gland development
GO:0030336 negative regulation of cell migration
GO:0030501 positive regulation of bone mineralization
GO:0030666 endocytic vesicle membrane
GO:0031012 extracellular matrix
GO:0032349 positive regulation of aldosterone biosynthetic process
GO:0032967 positive regulation of collagen biosynthetic process
GO:0033080 immature T cell proliferation in thymus
GO:0038030 non-canonical Wnt signaling pathway via MAPK cascade
GO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway
GO:0042445 hormone metabolic process
GO:0043547 positive regulation of GTPase activity
GO:0045165 cell fate commitment
GO:0045596 negative regulation of cell differentiation
GO:0045669 positive regulation of osteoblast differentiation
GO:0045836 positive regulation of meiotic nuclear division
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0048018 receptor ligand activity
GO:0048599 oocyte development
GO:0051145 smooth muscle cell differentiation
GO:0051496 positive regulation of stress fiber assembly
GO:0051894 positive regulation of focal adhesion assembly
GO:0060070 canonical Wnt signaling pathway
GO:0060126 somatotropin secreting cell differentiation
GO:0060129 thyroid-stimulating hormone-secreting cell differentiation
GO:0060231 mesenchymal to epithelial transition
GO:0060748 tertiary branching involved in mammary gland duct morphogenesis
GO:0061045 negative regulation of wound healing
GO:0061180 mammary gland epithelium development
GO:0061184 positive regulation of dermatome development
GO:0061205 paramesonephric duct development
GO:0061369 negative regulation of testicular blood vessel morphogenesis
GO:0070062 extracellular exosome
GO:0071560 cellular response to transforming growth factor beta stimulus
GO:0072033 renal vesicle formation
GO:0072034 renal vesicle induction
GO:0072162 metanephric mesenchymal cell differentiation
GO:0072174 metanephric tubule formation
GO:0072273 metanephric nephron morphogenesis
GO:2000019 negative regulation of male gonad development
GO:2000066 positive regulation of cortisol biosynthetic process
GO:2000180 negative regulation of androgen biosynthetic process
GO:2000225 negative regulation of testosterone biosynthetic process
GO:2001234 negative regulation of apoptotic signaling pathway

Diseases

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Disease IDSourceNameDescription
158330 OMIMMullerian aplasia and hyperandrogenism (MULLAPL)A disorder of sex development. Affected females manifest dysgenesis of Mullerian duct derivatives absent or rudimentary uterus and vagina, functional ovaries, primary amenorrhea, hyperandrogenism and hirsutism. The disease is caused by variants affecting the gene represented in this entry.
611812 OMIM46,XX sex reversal with dysgenesis of kidneys, adrenals, and lungs (SERKAL)A disease characterized by the association of female-to-male sex reversal with dysgenesis of kidneys, adrenals, and lungs. The disease is caused by variants affecting the gene represented in this entry.