Entity Details

Primary name POMC
Entity type gene
Source Source Link

Details

PrimaryID5443
RefseqGeneNG_008997
SymbolPOMC
Nameproopiomelanocortin
Chromosome2
Location2p23.3
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-08-24
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsCOLI_HUMAN

GO terms

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GOName
GO:0001664 G protein-coupled receptor binding
GO:0002862 negative regulation of inflammatory response to antigenic stimulus
GO:0005102 signaling receptor binding
GO:0005179 hormone activity
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005782 peroxisomal matrix
GO:0006091 generation of precursor metabolites and energy
GO:0007165 signal transduction
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007218 neuropeptide signaling pathway
GO:0007267 cell-cell signaling
GO:0008217 regulation of blood pressure
GO:0019221 cytokine-mediated signaling pathway
GO:0030141 secretory granule
GO:0031640 killing of cells of other organism
GO:0031781 type 3 melanocortin receptor binding
GO:0031782 type 4 melanocortin receptor binding
GO:0032098 regulation of appetite
GO:0032720 negative regulation of tumor necrosis factor production
GO:0033059 cellular pigmentation
GO:0034774 secretory granule lumen
GO:0035821 modulation of process of other organism
GO:0042593 glucose homeostasis
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide
GO:0070873 regulation of glycogen metabolic process
GO:0070965 positive regulation of neutrophil mediated killing of fungus
GO:0070996 type 1 melanocortin receptor binding
GO:2000852 regulation of corticosterone secretion

Diseases

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Disease IDSourceNameDescription
609734 OMIMObesity, early-onset, with adrenal insufficiency and red hair (OBAIRH)An autosomal recessive disorder characterized by early-onset obesity due to severe hyperphagia, pigmentary abnormalities, mainly pale skin and red hair, and secondary hypocortisolism. The disease is caused by variants affecting the gene represented in this entry.
601665 OMIMObesity (OBESITY)A condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat. Disease susceptibility may be associated with variants affecting the gene represented in this entry.

Interactions

34 interactions

InteractorPartnerSourcesPublicationsLink
POMCHSF2BPBioGRID, IntAct32296183 details
POMCGLYCTKBioGRID, IntAct32296183 details
POMCATP6V0D2BioGRID, IntAct32296183 details
POMCKLHL42BioGRID, IntAct32296183 details
POMCNTAQ1BioGRID, IntAct32296183 details
POMCABI2BioGRID, IntAct32296183 details
POMCBHLHA9BioGRID, IntAct32296183 details
POMCNFKBIDBioGRID, IntAct32296183 details
POMCC1orf109BioGRID, IntAct32296183 details
POMCCCDC102BBioGRID, IntAct32296183 details
POMCTXN2BioGRID, IntAct32296183 details
POMCSUOXBioGRID, IntAct32296183 details
POMCESRRGBioGRID, IntAct32296183 details
POMCMKRN3BioGRID, IntAct32296183 details
POMCHDDC2BioGRID, IntAct32296183 details
POMCOAZ3BioGRID, IntAct32296183 details
POMCVTNBioGRID, HPRD2475499 details
POMCMC4RBioGRID, HPRD11101306 12165561 9058374 details
POMCMC5RBioGRID, HPRD11606131 8185570 9058374 details
POMCMC3RBioGRID9058374 details
POMCMC1RBioGRID, HPRD10942578 11041375 9058374 details
POMCAPPBioGRID21832049 details
POMCHLA-DRB3BioGRID, HPRD7477400 details
POMCMEP1AHPRD11278902 details
POMCMC2RHPRD12213892 details
POMCNRDCHPRD12590613 details
POMCFGF10HPRD12591959 details
POMCPAMHPRD18052119 details
POMCTSPAN11BioGRID, IntAct28514442 details
POMCKLHL15BioGRID, IntAct28514442 details
POMCTTLBioGRID, IntAct28514442 details
POMCUBR4BioGRID, IntAct28514442 details
POMCE2F4BioGRID, IntAct28514442 details
POMCAMD1BioGRID, IntAct28514442 details