Entity Details

Primary name MICB_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ29980
EntryNameMICB_HUMAN
FullNameMHC class I polypeptide-related sequence B
TaxID9606
Evidenceevidence at protein level
Length383
SequenceStatuscomplete
DateCreated2008-06-10
DateModified2021-06-02

Ontological Relatives

GenesMICB

GO terms

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GOName
GO:0002250 adaptive immune response
GO:0002429 immune response-activating cell surface receptor signaling pathway
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0006979 response to oxidative stress
GO:0009408 response to heat
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0016021 integral component of membrane
GO:0016032 viral process
GO:0019835 cytolysis
GO:0032526 response to retinoic acid
GO:0046629 gamma-delta T cell activation
GO:0046703 natural killer cell lectin-like receptor binding
GO:0050689 negative regulation of defense response to virus by host
GO:0050776 regulation of immune response

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR003597 Immunoglobulin C1-setDomainDomain
IPR007110 Immunoglobulin-like domainDomainDomain
IPR011161 MHC class I-like antigen recognition-likeDomainDomain
IPR011162 MHC classes I/II-like antigen recognition proteinFamilyHomologous superfamily
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR036179 Immunoglobulin-like domain superfamilyFamilyHomologous superfamily
IPR037055 MHC class I-like antigen recognition-like superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
180300 OMIMRheumatoid arthritis (RA)An inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Disease susceptibility is associated with variants affecting the gene represented in this entry. The MICB*004 allele is associated with rheumatoid arthritis.

Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
MICB_HUMANNKG2F_HUMANHPRD12133964 details
MICB_HUMANNKG2D_HUMANHPRD12902493 details