Entity Details

Primary name PTGIS
Entity type gene
Source Source Link

Details

PrimaryID5740
RefseqGeneNG_007940
SymbolPTGIS
Nameprostaglandin I2 synthase
Chromosome20
Location20q13.13
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-08-19
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsPTGIS_HUMAN

GO terms

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GOName
GO:0001516 prostaglandin biosynthetic process
GO:0004497 monooxygenase activity
GO:0005506 iron ion binding
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005901 caveola
GO:0006690 icosanoid metabolic process
GO:0008116 prostaglandin-I synthase activity
GO:0016021 integral component of membrane
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0019371 cyclooxygenase pathway
GO:0020037 heme binding
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0034356 NAD biosynthesis via nicotinamide riboside salvage pathway
GO:0035360 positive regulation of peroxisome proliferator activated receptor signaling pathway
GO:0045019 negative regulation of nitric oxide biosynthetic process
GO:0045766 positive regulation of angiogenesis
GO:0050728 negative regulation of inflammatory response
GO:0071347 cellular response to interleukin-1
GO:0071354 cellular response to interleukin-6
GO:0071456 cellular response to hypoxia
GO:0097190 apoptotic signaling pathway
GO:0106256 hydroperoxy icosatetraenoate dehydratase activity
GO:1900119 positive regulation of execution phase of apoptosis

Diseases

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Disease IDSourceNameDescription
145500 OMIMEssential hypertension (EHT)A condition in which blood pressure is consistently higher than normal with no identifiable cause. The disease may be caused by variants affecting the gene represented in this entry.

Interactions

6 interactions

InteractorPartnerSourcesPublicationsLink
PTGISAPPBioGRID21832049 details
PTGISPTGS2BioGRID21035466 details
PTGISPTGS1BioGRID21035466 details
PTGISCAV1BioGRID11339822 details
PTGISVIMBioGRID, IntAct30021884 details
PTGISKDM5BIntAct24937458 details