Entity Details

Primary name BAK1
Entity type gene
Source Source Link

Details

PrimaryID578
RefseqGene
SymbolBAK1
NameBCL2 antagonist/killer 1
Chromosome6
Location6p21.31
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-07-30
ModificationDate2021-06-22

Ontological Relatives

UniProt IDsBAK_HUMAN

GO terms

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GOName
GO:0001782 B cell homeostasis
GO:0001783 B cell apoptotic process
GO:0001836 release of cytochrome c from mitochondria
GO:0001974 blood vessel remodeling
GO:0002262 myeloid cell homeostasis
GO:0002352 B cell negative selection
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol
GO:0006915 apoptotic process
GO:0007420 brain development
GO:0007568 aging
GO:0008053 mitochondrial fusion
GO:0008283 cell population proliferation
GO:0008285 negative regulation of cell population proliferation
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0008635 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
GO:0009620 response to fungus
GO:0010046 response to mycotoxin
GO:0010225 response to UV-C
GO:0010248 establishment or maintenance of transmembrane electrochemical gradient
GO:0010332 response to gamma radiation
GO:0010524 positive regulation of calcium ion transport into cytosol
GO:0010629 negative regulation of gene expression
GO:0014070 response to organic cyclic compound
GO:0016032 viral process
GO:0031018 endocrine pancreas development
GO:0031072 heat shock protein binding
GO:0031100 animal organ regeneration
GO:0031307 integral component of mitochondrial outer membrane
GO:0031334 positive regulation of protein-containing complex assembly
GO:0032469 endoplasmic reticulum calcium ion homeostasis
GO:0032471 negative regulation of endoplasmic reticulum calcium ion concentration
GO:0033137 negative regulation of peptidyl-serine phosphorylation
GO:0034620 cellular response to unfolded protein
GO:0034644 cellular response to UV
GO:0035108 limb morphogenesis
GO:0042493 response to drug
GO:0042542 response to hydrogen peroxide
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043065 positive regulation of apoptotic process
GO:0044325 transmembrane transporter binding
GO:0044346 fibroblast apoptotic process
GO:0044877 protein-containing complex binding
GO:0045471 response to ethanol
GO:0045862 positive regulation of proteolysis
GO:0046872 metal ion binding
GO:0046902 regulation of mitochondrial membrane permeability
GO:0046930 pore complex
GO:0046982 protein heterodimerization activity
GO:0048597 post-embryonic camera-type eye morphogenesis
GO:0051087 chaperone binding
GO:0051400 BH domain binding
GO:0051726 regulation of cell cycle
GO:0051881 regulation of mitochondrial membrane potential
GO:0060068 vagina development
GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0070242 thymocyte apoptotic process
GO:0071260 cellular response to mechanical stimulus
GO:0090200 positive regulation of release of cytochrome c from mitochondria
GO:0097136 Bcl-2 family protein complex
GO:0097145 BAK complex
GO:0097190 apoptotic signaling pathway
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
GO:0097202 activation of cysteine-type endopeptidase activity
GO:1900103 positive regulation of endoplasmic reticulum unfolded protein response
GO:1901030 positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
GO:1902262 apoptotic process involved in blood vessel morphogenesis
GO:1903896 positive regulation of IRE1-mediated unfolded protein response

Diseases

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Interactions

50 interactions

InteractorPartnerSourcesPublicationsLink
BAK1BIDBioGRID, DIP, HPRD, IntAct, Molecular Connections10950869 12624108 23604079 23782464 25408501 details
BAK1BCL2BioGRID, HPRD, IntAct11206074 11728179 14980220 20836993 26004684 32064756 9463381 details
BAK1BCL2L1BioGRID, DIP, HPRD, IntAct, MINT, Molecular Connections10085290 11175750 12137781 14596824 15292519 15901672 16189514 17446862 19060904 20836993 22516262 23055042 23680104 26264872 29997244 31467278 31515488 32064756 32296183 32814053 9027312 details
BAK1MCL1BioGRID, DIP, HPRD, I2D, IntAct, MINT, Molecular Connections10579309 10837489 15077116 15637055 15901672 17097560 18040043 19148187 19483105 19968986 20023629 20836993 21132008 21613222 22516262 23680104 26004684 26045051 26186194 27818144 28514442 32296183 details
BAK1BAK1BioGRID, HPRD, IntAct, MINT, Molecular Connections10579309 15077116 15901672 16439990 17446862 23782464 details
BAK1UBE3AMINT9881696 details
BAK1HSD17B4BioGRID, IntAct21988832 details
BAK1ARHGDIABioGRID, MINT21900206 details
BAK1DBN1BioGRID, MINT21900206 details
BAK1BCL2A1BioGRID, HPRD, IntAct10381646 25416956 32296183 details
BAK1BCL2L2BioGRID, IntAct10381646 25115399 25416956 32296183 details
BAK1GRNIntAct32814053 details
BAK1HSPB1IntAct32814053 details
BAK1PSEN2IntAct32814053 details
BAK1KIF1BIntAct32814053 details
BAK1ATXN10IntAct32814053 details
BAK1RNF11IntAct32814053 details
BAK1JPH3IntAct32814053 details
BAK1SPRED1IntAct32814053 details
BAK1SOD1IntAct32814053 details
BAK1TP53BioGRID, HPRD15077116 21712378 25408501 27818144 32064756 details
BAK1NFKBIBBioGRID8887627 details
BAK1HERC1BioGRID25408501 details
BAK1BAXBioGRID, HPRD, IntAct, MINT11571294 15901672 16439990 17289999 21712378 details
BAK1VDAC2BioGRID, HPRD, IntAct12881569 17353931 details
BAK1RTL10IntAct23055042 details
BAK1HSPD1BioGRID, HPRD12070120 details
BAK1GIMAP5BioGRID16509771 details
BAK1ND5BioGRID25115399 details
BAK1MAPK8BioGRID19910452 details
BAK1BCL2L10HPRD9878060 details
BAK1VDAC1HPRD10639121 9843949 details
BAK1ERN1HPRD16645094 details
BAK1DFFABioGRID, IntAct17353931 details
BAK1SRRM2BioGRID, IntAct17353931 details
BAK1ACTR2BioGRID, IntAct17353931 details
BAK1KRT31BioGRID, IntAct17353931 details
BAK1AKAP13BioGRID, IntAct17353931 details
BAK1MYCBP2BioGRID, IntAct17353931 details
BAK1FBLBioGRID, IntAct17353931 details
BAK1FRYLBioGRID, IntAct17353931 details
BAK1BECN1MINT17446862 details
BAK1MFN2DIP, MINT17606912 19168699 details
BAK1MFN1DIP, HPRD, MINT17606912 19168699 details
BAK1BCL2L11IntAct23374347 details
BAK1TOMM40BioGRID22939629 details
BAK1TOMM7BioGRID22939629 details
BAK1ABCB10BioGRID22939629 details
BAK1RNF4BioGRID29180619 details
BAK1VIRMABioGRID29507755 details