Entity Details

Primary name ROCK1
Entity type gene
Source Source Link

Details

PrimaryID6093
RefseqGeneNG_042178
SymbolROCK1
NameRho associated coiled-coil containing protein kinase 1
Chromosome18
Location18q11.1
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-08-18
ModificationDate2021-06-13

Ontological Relatives

UniProt IDsROCK1_HUMAN

GO terms

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GOName
GO:0000139 Golgi membrane
GO:0000281 mitotic cytokinesis
GO:0001726 ruffle
GO:0001837 epithelial to mesenchymal transition
GO:0003180 aortic valve morphogenesis
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0005814 centriole
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0006468 protein phosphorylation
GO:0006915 apoptotic process
GO:0006939 smooth muscle contraction
GO:0007159 leukocyte cell-cell adhesion
GO:0007165 signal transduction
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007249 I-kappaB kinase/NF-kappaB signaling
GO:0007266 Rho protein signal transduction
GO:0010494 cytoplasmic stress granule
GO:0010506 regulation of autophagy
GO:0010508 positive regulation of autophagy
GO:0010613 positive regulation of cardiac muscle hypertrophy
GO:0010628 positive regulation of gene expression
GO:0016525 negative regulation of angiogenesis
GO:0018105 peptidyl-serine phosphorylation
GO:0018107 peptidyl-threonine phosphorylation
GO:0019828 aspartic-type endopeptidase inhibitor activity
GO:0022614 membrane to membrane docking
GO:0030027 lamellipodium
GO:0030036 actin cytoskeleton organization
GO:0030155 regulation of cell adhesion
GO:0030334 regulation of cell migration
GO:0030866 cortical actin cytoskeleton organization
GO:0031032 actomyosin structure organization
GO:0031175 neuron projection development
GO:0031267 small GTPase binding
GO:0032059 bleb
GO:0032091 negative regulation of protein binding
GO:0032956 regulation of actin cytoskeleton organization
GO:0034774 secretory granule lumen
GO:0035509 negative regulation of myosin-light-chain-phosphatase activity
GO:0042326 negative regulation of phosphorylation
GO:0043312 neutrophil degranulation
GO:0043410 positive regulation of MAPK cascade
GO:0045616 regulation of keratinocyte differentiation
GO:0045664 regulation of neuron differentiation
GO:0046872 metal ion binding
GO:0048010 vascular endothelial growth factor receptor signaling pathway
GO:0048013 ephrin receptor signaling pathway
GO:0048156 tau protein binding
GO:0048598 embryonic morphogenesis
GO:0050321 tau-protein kinase activity
GO:0050900 leukocyte migration
GO:0050901 leukocyte tethering or rolling
GO:0051045 negative regulation of membrane protein ectodomain proteolysis
GO:0051451 myoblast migration
GO:0051492 regulation of stress fiber assembly
GO:0051893 regulation of focal adhesion assembly
GO:0051894 positive regulation of focal adhesion assembly
GO:0061157 mRNA destabilization
GO:0070168 negative regulation of biomineral tissue development
GO:0070507 regulation of microtubule cytoskeleton organization
GO:0071559 response to transforming growth factor beta
GO:0072518 Rho-dependent protein serine/threonine kinase activity
GO:0072659 protein localization to plasma membrane
GO:0090521 glomerular visceral epithelial cell migration
GO:0097746 blood vessel diameter maintenance
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:0110061 regulation of angiotensin-activated signaling pathway
GO:0140058 neuron projection arborization
GO:1900223 positive regulation of amyloid-beta clearance
GO:1900242 regulation of synaptic vesicle endocytosis
GO:1901888 regulation of cell junction assembly
GO:1902003 regulation of amyloid-beta formation
GO:1902430 negative regulation of amyloid-beta formation
GO:1902992 negative regulation of amyloid precursor protein catabolic process
GO:1903140 regulation of establishment of endothelial barrier
GO:1903347 negative regulation of bicellular tight junction assembly
GO:1905205 positive regulation of connective tissue replacement
GO:1990776 response to angiotensin
GO:2000114 regulation of establishment of cell polarity
GO:2000145 regulation of cell motility

Diseases

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Interactions

102 interactions

InteractorPartnerSourcesPublicationsLink
ROCK1SMAD2BioGRID, HPRD, MINT15231748 details
ROCK1ROCK1HPRD, IntAct16249185 details
ROCK1RHOABioGRID, HPRD, IntAct, MINT12773565 14660612 21281639 31431478 8798490 8816443 details
ROCK1TSG101BioGRID, HPRD, MINT17853893 details
ROCK1MYBPHMINT22085929 details
ROCK1MAGEB4BioGRID, IntAct25416956 26186194 28514442 details
ROCK1LMO2BioGRID, IntAct25416956 details
ROCK1FAM124ABioGRID, IntAct25416956 details
ROCK1CFAP206BioGRID, IntAct25416956 details
ROCK1POLR3CBioGRID, IntAct25416956 details
ROCK1HMGB2UniProt32867128 details
ROCK1CDC25ABioGRID, HPRD14657354 details
ROCK1RND3BioGRID, HPRD12773565 details
ROCK1LIMK2BioGRID, HPRD10436159 11018042 11340065 23082153 details
ROCK1ITSN2BioGRID22558309 details
ROCK1CASP3BioGRID, HPRD11283607 18723680 details
ROCK1CASP7BioGRID18723680 details
ROCK1IKBKBBioGRID24240172 details
ROCK1TRIM15BioGRID25450970 details
ROCK1UBE2TBioGRID28162934 details
ROCK1MLC1BioGRID23082153 details
ROCK1TPPPBioGRID23093407 details
ROCK1FRMD5MINT25448675 details
ROCK1MYH9DIP26368311 details
ROCK1PFN2BioGRID, HPRD14517206 details
ROCK1GAB1BioGRID12748184 details
ROCK1CFL1BioGRID10436159 details
ROCK1HGSBioGRID26819309 details
ROCK1SLC9A1BioGRID26819309 details
ROCK1CDKN3BioGRID24704824 details
ROCK1RHOBTB1BioGRID31431478 details
ROCK1RHOCHPRD8816443 details
ROCK1RDXHPRD9456324 details
ROCK1CDC34HPRD16123592 details
ROCK1VIMHPRD9565595 details
ROCK1MSNHPRD9516463 9856983 details
ROCK1LIMK1HPRD10436159 10559936 10652353 11340065 details
ROCK1PPP1R12AHPRD10601309 11931630 12220642 12563012 12600888 9354661 details
ROCK1DPYSL2HPRD10818093 12482610 details
ROCK1CRMP1HPRD12482610 details
ROCK1IRS1HPRD11739394 details
ROCK1EZRHPRD10970850 11387207 details
ROCK1DESHPRD10574968 details
ROCK1ARHGAP24HPRD16862148 details
ROCK1ADD1HPRD10209029 details
ROCK1GFAPHPRD2114109 2155236 7822264 9099667 details
ROCK1ARRB1BioGRID, IntAct17620599 details
ROCK1NCLMINT21281639 details
ROCK1NEBMINT21281639 details
ROCK1HSPA1AMINT21281639 details
ROCK1HSPA1BMINT21281639 details
ROCK1HSP90AB1MINT21281639 details
ROCK1XRCC5BioGRID, IntAct26496610 details
ROCK1NEIL3BioGRID, IntAct26496610 details
ROCK1NOTCH1BioGRID, MINT23022380 details
ROCK1IL20RABioGRID, IntAct28514442 details
ROCK1ROCK2BioGRID, IntAct28514442 details
ROCK1ADD2BioGRID, IntAct28514442 details
ROCK1LAMP1BioGRID, IntAct29568061 34079125 details
ROCK1MED23BioGRID, MINT25281560 details
ROCK1PRKAR1ABioGRID, IntAct31980649 details
ROCK1PXNBioGRID, IntAct31980649 details
ROCK1RAB5ABioGRID, IntAct31980649 details
ROCK1ELK4BioGRID, IntAct31980649 details
ROCK1KDM4DBioGRID, MINT24981860 details
ROCK1HNRNPA1BioGRID17643375 details
ROCK1SMURF1BioGRID23184937 details
ROCK1CDK15BioGRID23602568 details
ROCK1ANKFY1BioGRID22863883 details
ROCK1MON2BioGRID22863883 details
ROCK1WASHC2ABioGRID22863883 details
ROCK1WASHC4BioGRID22863883 details
ROCK1NTRK1BioGRID25921289 details
ROCK1TNS2BioGRID27880917 details
ROCK1CYLDBioGRID27591049 details
ROCK1UBE2MBioGRID28581483 details
ROCK1HRASBioGRID30442766 30639242 details
ROCK1KRASBioGRID30442766 34079125 details
ROCK1NRASBioGRID30442766 30639242 details
ROCK1PLEKHA4BioGRID31091453 details
ROCK1ANLNBioGRID31586073 details
ROCK1BRD4BioGRID31239290 details
ROCK1YWHAEBioGRID23472066 details
ROCK1CUL4ABioGRID32235678 details
ROCK1TAF4BioGRID24981860 details
ROCK1CHERPBioGRID24981860 details
ROCK1UFL1BioGRID32807901 details
ROCK1TP53BioGRID32807901 details
ROCK1ARF6BioGRID34079125 details
ROCK1FLOT1BioGRID34079125 details
ROCK1IMPDH2BioGRID34079125 details
ROCK1LAMP2BioGRID34079125 details
ROCK1LAMP3BioGRID34079125 details
ROCK1LAMTOR1BioGRID34079125 details
ROCK1LYNBioGRID34079125 details
ROCK1AFDNBioGRID34079125 details
ROCK1RAB2ABioGRID34079125 details
ROCK1RAB35BioGRID34079125 details
ROCK1RAB4ABioGRID34079125 details
ROCK1RHOBBioGRID34079125 details
ROCK1NXF1BioGRID22658674 details
ROCK1VIRMABioGRID29507755 details