Entity Details

Primary name STK11
Entity type gene
Source Source Link

Details

PrimaryID6794
RefseqGeneNG_007460
SymbolSTK11
Nameserine/threonine kinase 11
Chromosome19
Location19p13.3
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-08-24
ModificationDate2021-06-20

Ontological Relatives

UniProt IDsSTK11_HUMAN

GO terms

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GOName
GO:0000287 magnesium ion binding
GO:0001558 regulation of cell growth
GO:0001894 tissue homeostasis
GO:0001944 vasculature development
GO:0002039 p53 binding
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0006468 protein phosphorylation
GO:0006470 protein dephosphorylation
GO:0006914 autophagy
GO:0006974 cellular response to DNA damage stimulus
GO:0007283 spermatogenesis
GO:0007409 axonogenesis
GO:0008285 negative regulation of cell population proliferation
GO:0010212 response to ionizing radiation
GO:0010508 positive regulation of autophagy
GO:0016020 membrane
GO:0030010 establishment of cell polarity
GO:0030275 LRR domain binding
GO:0030295 protein kinase activator activity
GO:0030308 negative regulation of cell growth
GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway
GO:0032147 activation of protein kinase activity
GO:0042593 glucose homeostasis
GO:0043276 anoikis
GO:0045059 positive thymic T cell selection
GO:0046777 protein autophosphorylation
GO:0048814 regulation of dendrite morphogenesis
GO:0050772 positive regulation of axonogenesis
GO:0050852 T cell receptor signaling pathway
GO:0051645 Golgi localization
GO:0051896 regulation of protein kinase B signaling
GO:0060070 canonical Wnt signaling pathway
GO:0060770 negative regulation of epithelial cell proliferation involved in prostate gland development
GO:0070062 extracellular exosome
GO:0071493 cellular response to UV-B
GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0097484 dendrite extension
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:0120163 negative regulation of cold-induced thermogenesis
GO:1900182 positive regulation of protein localization to nucleus
GO:1901610 positive regulation of vesicle transport along microtubule
GO:1901796 regulation of signal transduction by p53 class mediator
GO:1904262 negative regulation of TORC1 signaling

Diseases

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Disease IDSourceNameDescription
175200 OMIMPeutz-Jeghers syndrome (PJS)An autosomal dominant disorder characterized by melanocytic macules of the lips, multiple gastrointestinal hamartomatous polyps and an increased risk for various neoplasms, including gastrointestinal cancer. The disease is caused by variants affecting the gene represented in this entry.
273300 OMIMTesticular germ cell tumor (TGCT)A common malignancy in males representing 95% of all testicular neoplasms. TGCTs have various pathologic subtypes including: unclassified intratubular germ cell neoplasia, seminoma (including cases with syncytiotrophoblastic cells), spermatocytic seminoma, embryonal carcinoma, yolk sac tumor, choriocarcinoma, and teratoma. The gene represented in this entry may be involved in disease pathogenesis.

Interactions

189 interactions

InteractorPartnerSourcesPublicationsLink
STK11SMARCA4BioGRID, IntAct11445556 14676191 28205554 details
STK11STRADBBioGRID, HPRD, IntAct14676191 20562859 28514442 details
STK11STRADABioGRID, DIP, HPRD, IntAct, MINT12805220 14676191 15561763 15733851 19513107 20562859 21860411 25241761 25852190 26479318 28514442 31554794 details
STK11MARK4BioGRID, HPRD, IntAct14676191 details
STK11SNRKBioGRID, HPRD, MINT15733851 details
STK11MOB4HPRD, IntAct16169070 details
STK11WDR6BioGRID, IntAct17216128 details
STK11TNIP2BioGRID, HPRD, IntAct, UniProt12595760 12753905 27609421 details
STK11STK11BioGRID, HPRD, IntAct11668633 20562859 28205554 details
STK11TBC1D23BioGRID, MINT21516116 details
STK11TP53BioGRID, HPRD, I2D11430832 21317932 28205554 details
STK11YWHAGBioGRID, MINT22575644 28205554 details
STK11YWHAHMINT22575644 details
STK11YWHAZMINT22575644 details
STK11PRKAA1BioGRID, MINT16912160 22575644 31217475 31995728 details
STK11AKT1BioGRID, MINT24412244 28205554 details
STK11ALDOBBioGRID, MINT24412244 details
STK11ANP32BBioGRID, MINT24412244 details
STK11TRMOBioGRID, MINT24412244 details
STK11CDC14BBioGRID, MINT24412244 details
STK11CYLC2BioGRID, MINT24412244 details
STK11FBP1BioGRID, MINT24412244 details
STK11FBP2BioGRID, MINT24412244 details
STK11HRASBioGRID, MINT24412244 details
STK11IGFBP3BioGRID, MINT24412244 details
STK11CCDC180BioGRID, MINT24412244 details
STK11LEF1BioGRID, MINT24412244 details
STK11MAP2K1BioGRID, MINT24412244 details
STK11MAPKAPK3MINT24412244 details
STK11NANSBioGRID, MINT24412244 details
STK11PPP2CBBioGRID, MINT24412244 details
STK11RASA1BioGRID, MINT24412244 details
STK11STX17BioGRID, MINT24412244 details
STK11TDRD7BioGRID, MINT24412244 details
STK11XPABioGRID, MINT24412244 details
STK11ZNF189BioGRID, MINT24412244 details
STK11ZNF510BioGRID, MINT24412244 details
STK11CALM1MINT25640309 details
STK11CALM2BioGRID, MINT25640309 details
STK11CALM3MINT25640309 details
STK11ADIPOR1BioGRID, MINT25640309 details
STK11ARG2BioGRID, MINT25640309 details
STK11CTSBBioGRID, MINT25640309 details
STK11CFL2BioGRID, MINT25640309 details
STK11CRY2BioGRID, MINT25640309 details
STK11ERLEC1BioGRID, MINT25640309 details
STK11D2HGDHBioGRID, MINT25640309 details
STK11EEF1A2BioGRID, MINT25640309 details
STK11ND2BioGRID, MINT25640309 details
STK11GNPDA1BioGRID, MINT25640309 details
STK11FAIM2BioGRID, MINT25640309 details
STK11PHF23BioGRID, MINT25640309 details
STK11MOCS2BioGRID, MINT25640309 details
STK11PDXPBioGRID, MINT25640309 details
STK11PLD3BioGRID, MINT25640309 details
STK11SEPTIN9BioGRID, MINT25640309 details
STK11STK24BioGRID, MINT25640309 details
STK11THOP1BioGRID, MINT25640309 details
STK11TSG101BioGRID, MINT25640309 details
STK11TUBA1ABioGRID, MINT25640309 details
STK11TUBB4ABioGRID, MINT25640309 details
STK11VPS72BioGRID, MINT25640309 details
STK11BCAS3BioGRID, MINT25640309 details
STK11CYP17A1BioGRID, MINT25640309 details
STK11KLK7BioGRID, MINT25640309 details
STK11LYPD3BioGRID, MINT25640309 details
STK11NAT2BioGRID, MINT25640309 details
STK11RHOBTB2BioGRID, MINT25640309 details
STK11S100A14BioGRID, MINT25640309 details
STK11SERPINB5BioGRID, MINT25640309 details
STK11ST14BioGRID, MINT25640309 details
STK11THRSPBioGRID, MINT25640309 details
STK11TRIM25BioGRID, MINT25640309 details
STK11PRSS50BioGRID, MINT25640309 details
STK11NR4A1DIP25822914 details
STK11STK11IPBioGRID, HPRD11741830 details
STK11MARK2BioGRID, HPRD14976552 16396636 details
STK11SIK1BioGRID16396636 details
STK11UBE2D2BioGRID21860411 details
STK11APPBioGRID21832049 details
STK11ETV4BioGRID16912160 21150337 details
STK11SIRT1BioGRID18687677 27259994 details
STK11SPDEFBioGRID16912160 details
STK11MAPRE1BioGRID24552808 details
STK11HERC2BioGRID27259994 details
STK11PTENBioGRID, HPRD15987703 details
STK11ARAFBioGRID28205554 details
STK11ARNTBioGRID28205554 details
STK11CBLCBioGRID28205554 details
STK11CCND2BioGRID28205554 details
STK11CDK4BioGRID28205554 details
STK11CDK6BioGRID28205554 details
STK11CDKN2ABioGRID28205554 details
STK11ERBB2BioGRID28205554 details
STK11FZR1BioGRID28205554 details
STK11GLIS2BioGRID28205554 details
STK11HGFBioGRID28205554 details
STK11KAT2ABioGRID28205554 details
STK11KDELR2BioGRID28205554 details
STK11MAP2K5BioGRID28205554 details
STK11METBioGRID28205554 details
STK11MYCBioGRID28205554 details
STK11NF2BioGRID28205554 details
STK11RASSF1BioGRID28205554 details
STK11CCNE1BioGRID28205554 details
STK11CDKN2BBioGRID28205554 details
STK11FGFR4BioGRID28205554 details
STK11LATS2BioGRID28205554 details
STK11MAP2K3BioGRID28205554 28628118 details
STK11ABCB5BioGRID28205554 details
STK11AURKABioGRID28205554 details
STK11BECN1BioGRID28205554 details
STK11BRAFBioGRID28205554 details
STK11CD44BioGRID28205554 details
STK11CDKN2CBioGRID28205554 details
STK11DACH1BioGRID28205554 details
STK11GRM1BioGRID28205554 details
STK11HIF1ABioGRID28205554 details
STK11MAP2K6BioGRID28205554 details
STK11MAP3K5BioGRID28205554 details
STK11MAPK14BioGRID28205554 details
STK11MDM2BioGRID28205554 details
STK11PDGFRABioGRID28205554 details
STK11PIK3CABioGRID28205554 details
STK11SMAD1BioGRID28205554 details
STK11SOX4BioGRID28205554 details
STK11EPHA2BioGRID28205554 details
STK11TEAD2BioGRID28205554 details
STK11TERTBioGRID28205554 details
STK11TNFRSF1ABioGRID28205554 details
STK11WT1BioGRID28205554 details
STK11MAPK3BioGRID24412244 details
STK11BAP1BioGRID32819560 details
STK11FKBP5BioGRID, IntAct14676191 20562859 25036637 25852190 28514442 details
STK11CAB39BioGRID, DIP, HPRD, IntAct, MINT14676191 15561763 15733851 19513107 20562859 25241761 25852190 26479318 28514442 31217475 31554794 details
STK11HSP90AA1BioGRID, IntAct14668798 14676191 21860411 22939624 25036637 28514442 details
STK11CDC37BioGRID, HPRD, IntAct12489981 14668798 14676191 20562859 21860411 25036637 details
STK11PARD3HPRD, IntAct14676191 details
STK11HSP90AB1BioGRID, IntAct22939624 28514442 details
STK11PRKAA2BioGRID, HPRD, IntAct10642499 19274086 25241761 details
STK11RPS6KB1BioGRID, HPRD, IntAct11297520 11853558 25241761 details
STK11MLF1IntAct25036637 details
STK11BAG4IntAct25036637 details
STK11MLF2IntAct25036637 details
STK11STIP1IntAct25036637 details
STK11STUB1BioGRID, IntAct21860411 25036637 details
STK11PTGES3IntAct25036637 details
STK11MST1DIP24362629 details
STK11LATS1DIP24362629 details
STK11MARK1DIP, HPRD14517247 14976552 24362629 details
STK11GSK3BBioGRID22270359 details
STK11TP63BioGRID21150337 details
STK11SNAI1BioGRID29601127 details
STK11FBXL14BioGRID29601127 details
STK11ATMBioGRID, HPRD11853558 12234250 15713674 details
STK11COPS5BioGRID30710502 details
STK11FBXO22BioGRID31217475 details
STK11TNKSBioGRID31554794 details
STK11TNKS2BioGRID31554794 details
STK11RNF146BioGRID31554794 details
STK11UBE2OBioGRID31900314 details
STK11RPS6KA3HPRD11297520 11853558 details
STK11PRKACAHPRD11297520 11853558 details
STK11RPS6KA5HPRD11297520 details
STK11KIF23BioGRID, IntAct14676191 details
STK11RPAP3BioGRID, IntAct14676191 details
STK11LIMS1BioGRID, IntAct14676191 details
STK11USP11BioGRID, IntAct14676191 details
STK11SMARCC1BioGRID, IntAct14676191 details
STK11HSPA1ABioGRID, IntAct14676191 details
STK11HSPA1BIntAct14676191 details
STK11AP2M1BioGRID, IntAct20368287 details
STK11EIF2B1BioGRID, IntAct20368287 details
STK11WDR48BioGRID, IntAct19615732 details
STK11CAB39LBioGRID, IntAct20562859 26186194 28514442 details
STK11NUAK1I2D21317932 details
STK11COPS4BioGRID, IntAct25852190 details
STK11H2AXBioGRID, IntAct25852190 details
STK11CCDC136BioGRID, IntAct25852190 details
STK11COPS3BioGRID, IntAct25852190 details
STK11PIP4K2ABioGRID, IntAct28514442 details
STK11C5orf24BioGRID, IntAct28514442 details
STK11ABRAXAS2BioGRID, IntAct28514442 details
STK11IVDBioGRID, IntAct28514442 details
STK11KDM4ABioGRID, IntAct28514442 details
STK11NEMFBioGRID, IntAct28514442 details
STK11DVL2BioGRID, IntAct28514442 details
STK11CDKN1AI2D21317932 details
STK11DDX58BioGRID32513696 details