Entity Details

Primary name TBB8_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ3ZCM7
EntryNameTBB8_HUMAN
FullNameTubulin beta-8 chain
TaxID9606
Evidenceevidence at protein level
Length444
SequenceStatuscomplete
DateCreated2008-02-26
DateModified2021-06-02

Ontological Relatives

GenesTUBB8

GO terms

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GOName
GO:0000226 microtubule cytoskeleton organization
GO:0000278 mitotic cell cycle
GO:0001556 oocyte maturation
GO:0003924 GTPase activity
GO:0005200 structural constituent of cytoskeleton
GO:0005525 GTP binding
GO:0005737 cytoplasm
GO:0005874 microtubule
GO:0007056 spindle assembly involved in female meiosis
GO:0070062 extracellular exosome
GO:0072687 meiotic spindle

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR000217 TubulinFamilyFamily
IPR002453 Beta tubulinFamilyFamily
IPR003008 Tubulin/FtsZ, GTPase domainDomainDomain
IPR008280 Tubulin/FtsZ, C-terminalFamilyHomologous superfamily
IPR013838 Beta tubulin, autoregulation binding siteSiteBinding site
IPR017975 Tubulin, conserved siteSiteConserved site
IPR018316 Tubulin/FtsZ, 2-layer sandwich domainDomainDomain
IPR023123 Tubulin, C-terminalFamilyHomologous superfamily
IPR036525 Tubulin/FtsZ, GTPase domain superfamilyFamilyHomologous superfamily
IPR037103 Tubulin/FtsZ-like, C-terminal domainFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
616780 OMIMOocyte maturation defect 2 (OOMD2)An autosomal dominant infertility disorder caused by defective oocyte maturation. Oocytes are arrested at metaphase I, and have an abnormal or no detectable spindle on polarization microscopy. The disease is caused by variants affecting the gene represented in this entry.

Interactions

4 interactions