Entity Details

Primary name TERT
Entity type gene
Source Source Link

Details

PrimaryID7015
RefseqGeneNG_009265
SymbolTERT
Nametelomerase reverse transcriptase
Chromosome5
Location5p15.33
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-08-18
ModificationDate2021-06-20

Ontological Relatives

UniProt IDsTERT_HUMAN

GO terms

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GOName
GO:0000049 tRNA binding
GO:0000333 telomerase catalytic core complex
GO:0000723 telomere maintenance
GO:0000781 chromosome, telomeric region
GO:0000783 nuclear telomere cap complex
GO:0001172 transcription, RNA-templated
GO:0001223 transcription coactivator binding
GO:0003677 DNA binding
GO:0003720 telomerase activity
GO:0003721 telomerase RNA reverse transcriptase activity
GO:0003723 RNA binding
GO:0003964 RNA-directed DNA polymerase activity
GO:0003968 RNA-directed 5'-3' RNA polymerase activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005697 telomerase holoenzyme complex
GO:0005730 nucleolus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006278 RNA-dependent DNA biosynthetic process
GO:0007004 telomere maintenance via telomerase
GO:0007005 mitochondrion organization
GO:0008022 protein C-terminus binding
GO:0010629 negative regulation of gene expression
GO:0016605 PML body
GO:0016607 nuclear speck
GO:0022616 DNA strand elongation
GO:0030177 positive regulation of Wnt signaling pathway
GO:0030422 production of siRNA involved in RNA interference
GO:0031379 RNA-directed RNA polymerase complex
GO:0031647 regulation of protein stability
GO:0032092 positive regulation of protein binding
GO:0042162 telomeric DNA binding
GO:0042635 positive regulation of hair cycle
GO:0042645 mitochondrial nucleoid
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043524 negative regulation of neuron apoptotic process
GO:0045766 positive regulation of angiogenesis
GO:0046326 positive regulation of glucose import
GO:0046686 response to cadmium ion
GO:0046872 metal ion binding
GO:0047485 protein N-terminus binding
GO:0051000 positive regulation of nitric-oxide synthase activity
GO:0051087 chaperone binding
GO:0062103 double-stranded RNA biosynthetic process
GO:0070034 telomerase RNA binding
GO:0070200 establishment of protein localization to telomere
GO:0071456 cellular response to hypoxia
GO:0071897 DNA biosynthetic process
GO:0090399 replicative senescence
GO:0098680 template-free RNA nucleotidyltransferase
GO:1900087 positive regulation of G1/S transition of mitotic cell cycle
GO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II
GO:1903620 positive regulation of transdifferentiation
GO:1903704 negative regulation of production of siRNA involved in RNA interference
GO:1903799 negative regulation of production of miRNAs involved in gene silencing by miRNA
GO:1904707 positive regulation of vascular associated smooth muscle cell proliferation
GO:1904751 positive regulation of protein localization to nucleolus
GO:1904754 positive regulation of vascular associated smooth muscle cell migration
GO:1904837 beta-catenin-TCF complex assembly
GO:1990572 TERT-RMRP complex
GO:2000352 negative regulation of endothelial cell apoptotic process
GO:2000648 positive regulation of stem cell proliferation
GO:2000773 negative regulation of cellular senescence
GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

Diseases

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Interactions

113 interactions

InteractorPartnerSourcesPublicationsLink
TERTRUVBL1BioGRID, HPRD, IntAct18358808 details
TERTAKT1BioGRID, HPRD, MINT10224060 15843522 18775701 28205554 details
TERTSMG5bhf-ucl, BioGRID, HPRD12699629 details
TERTSMG6bhf-ucl, BioGRID, HPRD12699629 22011238 details
TERTPINX1bhf-ucl, BioGRID, HPRD, UniProt11701125 15381700 28255170 details
TERTSMARCA4DIP, MINT19571879 24550003 details
TERTTPP1BioGRID, DIP, HPRD17237767 25172512 details
TERTTERTDIP, HPRD11029039 11751869 23474713 details
TERTNCLBioGRID, HPRD15371412 details
TERTMCRS1BioGRID, HPRD15044100 details
TERTHSP90AA1BioGRID, HPRD10197982 11274138 12586360 15843522 19751963 20959453 details
TERTXRCC5BioGRID, HPRD12377759 21855630 details
TERTXRCC6BioGRID, HPRD12377759 details
TERTYWHAZBioGRID10835362 details
TERTYWHAQBioGRID, HPRD10835362 details
TERTMDM2BioGRID20453884 26370108 details
TERTTERF1BioGRID19487455 details
TERTPTGES3BioGRID, HPRD10197982 11274138 19751963 20959453 details
TERTCIB1BioGRID, HPRD15190070 20959453 details
TERTSTUB1BioGRID20959453 details
TERTDYRK2BioGRID23362280 details
TERTSLC7A11BioGRID23741361 details
TERTUBE2D3BioGRID23741361 details
TERTU2SURPBioGRID23741361 details
TERTIREB2BioGRID23741361 details
TERTTGFBR2BioGRID23741361 details
TERTGLABioGRID23741361 details
TERTSERBP1BioGRID23741361 details
TERTDYNLL1BioGRID23741361 details
TERTPHF20L1BioGRID23741361 details
TERTATP5F1BBioGRID23741361 details
TERTFAAP24BioGRID23741361 details
TERTPFDN1BioGRID23741361 details
TERTCCT5BioGRID23741361 details
TERTEIF2S1BioGRID23741361 details
TERTTIMM21BioGRID23741361 details
TERTTUBA1BBioGRID23741361 details
TERTPABPC1BioGRID23741361 details
TERTANXA2BioGRID23741361 details
TERTDDX51BioGRID23741361 details
TERTPBKBioGRID23741361 details
TERTSTEAP4BioGRID23741361 details
TERTACAA2BioGRID23741361 details
TERTENO1BioGRID23741361 details
TERTPPIABioGRID23741361 details
TERTHSPA4BioGRID11274138 details
TERTFOXO3BioGRID26370108 details
TERTFZR1BioGRID28205554 details
TERTMYCBioGRID28205554 32140074 details
TERTNF2BioGRID28205554 details
TERTBECN1BioGRID28205554 details
TERTBRAFBioGRID28205554 details
TERTCBLCBioGRID28205554 details
TERTCCND2BioGRID28205554 details
TERTCDK4BioGRID28205554 details
TERTCDK6BioGRID28205554 details
TERTCDKN2ABioGRID28205554 details
TERTDACH1BioGRID28205554 details
TERTGLIS2BioGRID28205554 details
TERTGRM1BioGRID28205554 details
TERTMAP2K5BioGRID28205554 details
TERTMAP3K5BioGRID28205554 details
TERTMETBioGRID28205554 details
TERTPDGFRABioGRID28205554 details
TERTRAF1BioGRID28205554 details
TERTRASSF1BioGRID28205554 details
TERTSOX3BioGRID28205554 details
TERTSOX4BioGRID28205554 details
TERTCCNE1BioGRID28205554 details
TERTCDKN2BBioGRID28205554 details
TERTFGFR4BioGRID28205554 details
TERTMAP2K3BioGRID28205554 details
TERTSTK11BioGRID28205554 details
TERTTEAD2BioGRID28205554 details
TERTNSD3BioGRID28205554 details
TERTXPO1HPRD10835362 details
TERTRUVBL2BioGRID, HPRD, IntAct18358808 details
TERTUPF1MINT21829167 details
TERTPMLbhf-ucl, BioGRID19567472 details
TERTTERF2MINT24550003 details
TERTCOILMINT24550003 details
TERTGNL3MINT24550003 details
TERTAGO2MINT24550003 details
TERTCTNNB1DIP19571879 details
TERTACDDIP23103865 details
TERTNPM1UniProt28255170 details
TERTTEP1BioGRID, HPRD11029039 9389643 details
TERTRELABioGRID, HPRD12517770 details
TERTMTORBioGRID, HPRD15843522 details
TERTRPS6KB1BioGRID, HPRD15843522 details
TERTMKRN1BioGRID15805468 details
TERTNAT10BioGRID18082603 details
TERTGNL3LBioGRID19487455 details
TERTPOT1BioGRID21855630 details
TERTHSPA1ABioGRID20959453 details
TERTUBR5BioGRID23362280 details
TERTDDB1BioGRID23362280 details
TERTDCAF1BioGRID23362280 23612978 details
TERTDAXXBioGRID25416818 details
TERTPRKCAHPRD9837921 details
TERTSRCHPRD12808100 details
TERTABL1HPRD10837221 details
TERTDKC1bhf-ucl, BioGRID, DIP, IntAct18358808 19179534 23474713 details
TERTWRAP53bhf-ucl19179534 details
TERTSMARCA2DIP19571879 details
TERTSMARCE1DIP19571879 details
TERTSMARCC2DIP19571879 details
TERTBRCA2BioGRID27433848 details
TERTNR2C2BioGRID30463901 details
TERTSOX14IntAct31481462 details
TERTFOXE1IntAct27852061 details
TERTELK1IntAct27852061 details
TERTAPEX1BioGRID28986522 details