Entity Details

Primary name TOP1
Entity type gene
Source Source Link

Details

PrimaryID7150
RefseqGeneNG_012262
SymbolTOP1
NameDNA topoisomerase I
Chromosome20
Location20q12
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1990-06-22
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsTOP1_HUMAN

GO terms

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GOName
GO:0000932 P-body
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0001650 fibrillar center
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003690 double-stranded DNA binding
GO:0003697 single-stranded DNA binding
GO:0003723 RNA binding
GO:0003917 DNA topoisomerase type I (single strand cut, ATP-independent) activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0005730 nucleolus
GO:0006260 DNA replication
GO:0006265 DNA topological change
GO:0006338 chromatin remodeling
GO:0007059 chromosome segregation
GO:0007623 circadian rhythm
GO:0012501 programmed cell death
GO:0016032 viral process
GO:0016310 phosphorylation
GO:0018105 peptidyl-serine phosphorylation
GO:0019904 protein domain specific binding
GO:0032922 circadian regulation of gene expression
GO:0032993 protein-DNA complex
GO:0040016 embryonic cleavage
GO:0042493 response to drug
GO:0043204 perikaryon
GO:0097100 supercoiled DNA binding

Diseases

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Interactions

318 interactions

InteractorPartnerSourcesPublicationsLink
TOP1NCLBioGRID, HPRD, IntAct, MINT10967121 15848144 8567649 9512561 details
TOP1SRSF1BioGRID, HPRD, IntAct12270705 15848144 20805487 8639538 9611241 details
TOP1PRKDCBioGRID, IntAct15848144 28415827 details
TOP1PARP1BioGRID, IntAct15247263 15848144 34079125 details
TOP1SF3B1BioGRID, IntAct12549820 15848144 details
TOP1NKX3-1BioGRID, DIP, IntAct17234752 27339988 details
TOP1ABL1MINT15448168 details
TOP1XRCC5BioGRID, Molecular Connections21679440 28415827 details
TOP1CSNK2A1BioGRID, HPRD2998765 details
TOP1CSNK2A2BioGRID2998765 details
TOP1TP53BioGRID, HPRD10468612 11805286 18697815 32807901 8639538 details
TOP1BTBD1BioGRID, HPRD11818025 21092135 details
TOP1BTBD2BioGRID, HPRD11818025 21092135 details
TOP1TOPORSBioGRID, HPRD10352183 17976381 20805487 details
TOP1UBE2IBioGRID, HPRD10759568 details
TOP1CDT1BioGRID18162579 details
TOP1DDB2BioGRID12549820 details
TOP1ERCC8BioGRID12549820 details
TOP1ATMBioGRID12549820 details
TOP1IRF4BioGRID12549820 details
TOP1BARD1BioGRID12549820 details
TOP1ELK3BioGRID12549820 details
TOP1TARBP2BioGRID12549820 details
TOP1KMT2ABioGRID12549820 details
TOP1IRF8BioGRID12549820 details
TOP1IRF9BioGRID12549820 details
TOP1SNW1BioGRID12549820 details
TOP1PRB1BioGRID12549820 details
TOP1SNRNP70BioGRID12549820 29802200 details
TOP1U2AF2BioGRID12549820 details
TOP1LSM4BioGRID12549820 details
TOP1GEMIN4BioGRID12549820 details
TOP1CDK8BioGRID12549820 details
TOP1BUB3BioGRID12549820 details
TOP1RBL1BioGRID12549820 details
TOP1RBL2BioGRID12549820 details
TOP1GRWD1BioGRID12549820 29991511 details
TOP1SYMPKBioGRID12549820 details
TOP1JAK1BioGRID12549820 details
TOP1LIG4BioGRID12549820 details
TOP1PPP2R2BBioGRID12549820 details
TOP1TRIM32BioGRID12549820 details
TOP1RCVRNBioGRID12549820 details
TOP1PYGMBioGRID12549820 details
TOP1APAF1BioGRID12549820 details
TOP1CKAP5BioGRID12549820 details
TOP1TUBD1BioGRID12549820 details
TOP1PDE10ABioGRID12549820 details
TOP1APPBioGRID21832049 details
TOP1ERGBioGRID24591637 details
TOP1MDM2BioGRID24147044 24583282 details
TOP1FSHRBioGRID, HPRD15196694 details
TOP1SRPK2BioGRID26167880 details
TOP1BRCA1BioGRID28415827 details
TOP1XRCC6BioGRID28415827 30585729 details
TOP1BRD2BioGRID31753913 details
TOP1SFPQBioGRID, HPRD, IntAct15848144 24981860 9756848 details
TOP1TOPBP1MINT17006541 details
TOP1MYCBioGRID, IntAct17314511 20195357 29467282 30415952 details
TOP1SMAD2IntAct20195357 details
TOP1JUNHPRD, MINT15923621 25609649 details
TOP1H3C6BioGRID, IntAct20504901 29568061 details
TOP1TAL1BioGRID16407974 details
TOP1SRSF11BioGRID, HPRD22939629 9756848 details
TOP1CDKN2ABioGRID12673200 15361825 18004878 details
TOP1MACROH2A1BioGRID17158748 details
TOP1PMS1BioGRID17148452 details
TOP1MGMTBioGRID16226712 details
TOP1H3-3ABioGRID20504901 details
TOP1HDAC5BioGRID21081666 details
TOP1NOP56BioGRID12777385 34079125 details
TOP1SF3B3BioGRID15848144 details
TOP1PCNABioGRID11254741 details
TOP1GTF3C1BioGRID9660958 details
TOP1SEM1BioGRID24515614 details
TOP1PES1BioGRID25825154 details
TOP1NR3C1BioGRID28611094 details
TOP1ERCC6BioGRID26030138 details
TOP1TOP1HPRD9756848 details
TOP1CASP3HPRD9933635 details
TOP1CASP6HPRD9933635 details
TOP1SUMO1HPRD11709553 12149243 12439742 details
TOP1NCOA6HPRD12519782 details
TOP1TDP1HPRD12618186 details
TOP1PRPF8BioGRID, IntAct15848144 details
TOP1NONOBioGRID, IntAct15848144 24981860 details
TOP1H1-2BioGRID, IntAct15848144 details
TOP1SNRNP200BioGRID, IntAct15848144 details
TOP1DDX21BioGRID, IntAct15848144 details
TOP1SNRPA1BioGRID, IntAct15848144 details
TOP1HNRNPA2B1BioGRID, IntAct15848144 details
TOP1HNRNPKBioGRID, IntAct15848144 details
TOP1ELAVL1BioGRID, IntAct15848144 details
TOP1DHX9BioGRID, IntAct15848144 details
TOP1DDX17BioGRID, IntAct15848144 details
TOP1HNRNPA1BioGRID, IntAct15848144 details
TOP1TOP2ABioGRID, IntAct15848144 26344197 details
TOP1HNRNPUIntAct15848144 details
TOP1HNRNPCBioGRID, IntAct15848144 22939629 details
TOP1NPM1BioGRID, IntAct15848144 details
TOP1HNRNPRBioGRID, IntAct15848144 details
TOP1DDX23BioGRID, IntAct15848144 34079125 details
TOP1H1-10BioGRID, IntAct15848144 details
TOP1NOP2BioGRID, IntAct15848144 26344197 details
TOP1EFTUD2BioGRID, IntAct15848144 28515276 details
TOP1TCOF1BioGRID, IntAct15848144 details
TOP1MKI67BioGRID, IntAct15848144 details
TOP1DDX5IntAct15848144 details
TOP1HNRNPLBioGRID, IntAct15848144 details
TOP1NAT10BioGRID, IntAct15848144 details
TOP1HNRNPA3BioGRID, IntAct15848144 details
TOP1FBLBioGRID, IntAct15848144 34079125 details
TOP1NAT8BIntAct15848144 details
TOP1PA2G4BioGRID, UniProt15064750 details
TOP1APLFBioGRID, MINT17396150 26186194 details
TOP1ESR1BioGRID, IntAct21182205 details
TOP1GABARAPL2IntAct20562859 details
TOP1GABARAPL1IntAct20562859 details
TOP1GABARAPIntAct20562859 details
TOP1MRPL58BioGRID, MINT20186120 details
TOP1HDGFBioGRID, IntAct21907836 details
TOP1OAS3BioGRID, IntAct21903422 details
TOP1EIF2AK2BioGRID, IntAct21903422 details
TOP1VCAM1BioGRID, IntAct19738201 22623428 details
TOP1CDK14BioGRID, IntAct23602568 details
TOP1CAND1BioGRID, IntAct21145461 details
TOP1CUL1BioGRID, IntAct21145461 details
TOP1COPS5BioGRID, IntAct21145461 details
TOP1CUL3BioGRID, IntAct21145461 details
TOP1HDAC9BioGRID, IntAct23752268 details
TOP1EGFRBioGRID, IntAct24780295 details
TOP1LAMB3BioGRID, IntAct26496610 details
TOP1TRIM26BioGRID, IntAct26496610 details
TOP1NLRP3BioGRID, IntAct26496610 details
TOP1GTF2E2BioGRID, IntAct28514442 details
TOP1EAF1BioGRID, IntAct26186194 28514442 details
TOP1PRICKLE3BioGRID, IntAct28514442 details
TOP1ZRANB2BioGRID, IntAct26186194 28514442 details
TOP1DUS4LBioGRID, IntAct28514442 details
TOP1CIDECBioGRID, IntAct28514442 details
TOP1ESAMBioGRID, IntAct28514442 details
TOP1RRP1BBioGRID, IntAct19710015 details
TOP1H3C1BioGRID, IntAct29568061 34079125 details
TOP1H3C4IntAct29568061 details
TOP1H3C3IntAct29568061 details
TOP1H3C11IntAct29568061 details
TOP1H3C8IntAct29568061 details
TOP1H3C12IntAct29568061 details
TOP1H3C10IntAct29568061 details
TOP1H3C2IntAct29568061 details
TOP1H3C7IntAct29568061 details
TOP1COX15BioGRID, IntAct29128334 details
TOP1DLSTBioGRID, IntAct29128334 details
TOP1PDHA1BioGRID, IntAct29128334 details
TOP1TP53BP1UniProt29656893 details
TOP1MDC1UniProt29656893 details
TOP1NEK4BioGRID, MINT25798074 details
TOP1H2AC13DIP24463511 details
TOP1H2AC15DIP24463511 details
TOP1H2AC16DIP24463511 details
TOP1H2AC17DIP24463511 details
TOP1H2AC11DIP24463511 details
TOP1ALDH1B1BioGRID, IntAct30021884 details
TOP1ALDH2BioGRID, IntAct30021884 details
TOP1H2BC21BioGRID, IntAct30021884 details
TOP1TPRBioGRID, IntAct22939629 30021884 details
TOP1ASXL3BioGRID, IntAct30021884 details
TOP1ADAMTS16BioGRID, IntAct30021884 details
TOP1SLC25A3BioGRID, IntAct30021884 details
TOP1RALBP1BioGRID, IntAct31980649 details
TOP1MYLK2BioGRID, IntAct31980649 details
TOP1GRB10BioGRID, IntAct31980649 details
TOP1CCNT1BioGRID, MINT24981860 details
TOP1HEXIM1BioGRID, MINT24981860 29845934 details
TOP1NDC80BioGRID, MINT24981860 details
TOP1SP100BioGRID, MINT24981860 details
TOP1KMT5CBioGRID, MINT24981860 details
TOP1TSPYL5BioGRID, MINT24981860 details
TOP1ZDHHC5UniProt31402609 details
TOP1DISC1BioGRID, MINT29961565 details
TOP1NDNBioGRID, MINT32529326 details
TOP1SIRT7BioGRID22586326 details
TOP1CDK2BioGRID21319273 details
TOP1HNRNPMBioGRID22939629 details
TOP1RPS14BioGRID22939629 details
TOP1SNRPD1BioGRID22939629 details
TOP1IKBioGRID22939629 details
TOP1RBM39BioGRID22939629 28302793 details
TOP1SF3B6BioGRID22939629 details
TOP1SUPT16HBioGRID22939629 26344197 details
TOP1UTP20BioGRID22939629 details
TOP1S100A9BioGRID22939629 details
TOP1NCSTNBioGRID22939629 details
TOP1RBM14BioGRID22939629 details
TOP1VCPBioGRID23383273 details
TOP1ITGA4BioGRID22623428 details
TOP1TARDBPBioGRID20020773 details
TOP1CUL7BioGRID24711643 details
TOP1OBSL1BioGRID24711643 details
TOP1EEDBioGRID24457600 details
TOP1RNF2BioGRID24457600 details
TOP1NTRK1BioGRID25921289 details
TOP1RBM25BioGRID24981860 26344197 details
TOP1PWP1BioGRID26344197 details
TOP1RBM28BioGRID26344197 details
TOP1TOP2BBioGRID26344197 details
TOP1MCM5BioGRID25963833 details
TOP1NF2BioGRID26549023 details
TOP1CDC5LBioGRID20467437 details
TOP1POU5F1BioGRID26687479 details
TOP1SNRPGBioGRID28514442 details
TOP1VDAC1BioGRID29128334 details
TOP1TRIM25BioGRID29117863 details
TOP1LMNABioGRID25948554 details
TOP1BMP4BioGRID27684187 details
TOP1NKX2-1BioGRID28192407 details
TOP1RNF4BioGRID29180619 details
TOP1CHD3BioGRID28977666 details
TOP1CHD4BioGRID28977666 details
TOP1MEPCEBioGRID24981860 29845934 details
TOP1LARP7BioGRID29845934 details
TOP1HERC2BioGRID29511261 details
TOP1KCMF1BioGRID29511261 details
TOP1RNF181BioGRID29511261 details
TOP1AGR2BioGRID30575818 details
TOP1FBXW7BioGRID29346117 details
TOP1DCPSBioGRID29478914 details
TOP1RC3H1BioGRID30209976 details
TOP1ATG16L1BioGRID30196744 details
TOP1PHBBioGRID27025967 details
TOP1TPT1BioGRID28846114 details
TOP1USP14BioGRID30425250 details
TOP1NR2C2BioGRID30463901 details
TOP1UCHL3BioGRID30559450 details
TOP1MTDHBioGRID22199357 details
TOP1UBE3CBioGRID30503554 details
TOP1PRDM16BioGRID30462309 details
TOP1H4C1BioGRID30804502 details
TOP1ARAFBioGRID29777862 details
TOP1STAU1BioGRID30948266 details
TOP1WWP2BioGRID31048545 details
TOP1BRD7BioGRID30940648 details
TOP1TRIM28BioGRID29955894 details
TOP1TRAIPBioGRID27462463 details
TOP1CMTR1BioGRID30320910 details
TOP1PLEKHA4BioGRID31091453 details
TOP1RAD18BioGRID31076518 details
TOP1NSD2BioGRID31248990 details
TOP1FANCD2BioGRID31180492 details
TOP1ZC3H18BioGRID29298432 details
TOP1UBR5BioGRID31365120 details
TOP1CITBioGRID31586073 details
TOP1ANLNBioGRID31586073 details
TOP1CHMP4BBioGRID31586073 details
TOP1CHMP4CBioGRID31586073 details
TOP1ECT2BioGRID31586073 details
TOP1KIF14BioGRID31586073 details
TOP1KIF20ABioGRID31586073 details
TOP1KIF23BioGRID31586073 details
TOP1PRC1BioGRID31586073 details
TOP1GRSF1BioGRID32877691 details
TOP1INSBioGRID32457219 details
TOP1ZNF263BioGRID32051553 details
TOP1MAFBBioGRID31822558 details
TOP1BRD4BioGRID31239290 32416067 details
TOP1NUPR1BioGRID32780723 details
TOP1FBP1BioGRID32041737 details
TOP1LGALS9BioGRID31995728 details
TOP1IFI16BioGRID31665637 details
TOP1WDR76BioGRID31353912 details
TOP1EIF5ABioGRID24981860 details
TOP1PSPC1BioGRID24981860 details
TOP1NUFIP2BioGRID24981860 details
TOP1SART1BioGRID24981860 details
TOP1RPS19BioGRID24981860 details
TOP1DDX42BioGRID24981860 details
TOP1PPIL4BioGRID24981860 details
TOP1RPL23ABioGRID24981860 details
TOP1NUDT21BioGRID24981860 details
TOP1CPSF7BioGRID24981860 details
TOP1PPP1R10BioGRID24981860 details
TOP1METTL17BioGRID24981860 details
TOP1FAM76BBioGRID24981860 details
TOP1NSRP1BioGRID24981860 details
TOP1ATXN2LBioGRID24981860 details
TOP1CTTNBioGRID24981860 details
TOP1CBX4BioGRID24981860 details
TOP1PRPF4BBioGRID24981860 details
TOP1FIP1L1BioGRID24981860 details
TOP1YY1BioGRID24981860 details
TOP1DCAF13BioGRID24981860 details
TOP1PRPF40ABioGRID24981860 details
TOP1MECP2BioGRID24981860 details
TOP1CPSF6BioGRID24981860 details
TOP1WDR82BioGRID24981860 details
TOP1CDK9BioGRID24981860 details
TOP1LRPAP1BioGRID24981860 details
TOP1POP1BioGRID24981860 details
TOP1MFAP1BioGRID24981860 details
TOP1RPSABioGRID24981860 details
TOP1RCL1BioGRID24981860 details
TOP1C1orf35BioGRID24981860 details
TOP1DDX56BioGRID24981860 details
TOP1TAF2BioGRID24981860 details
TOP1CD274BioGRID32941674 details
TOP1RECQL5BioGRID32900933 details
TOP1UFL1BioGRID32807901 details
TOP1DDRGK1BioGRID32807901 details
TOP1CBX3BioGRID34079125 details
TOP1POLR1GBioGRID34079125 details
TOP1CENPABioGRID34079125 details
TOP1COILBioGRID34079125 details
TOP1H2BC8BioGRID34079125 details
TOP1RPL31BioGRID34079125 details
TOP1RPS6BioGRID34079125 details
TOP1ZNF330BioGRID34079125 details
TOP1IL7RBioGRID23151878 details
TOP1VIRMABioGRID29507755 details