Entity Details

Primary name VEGFC
Entity type gene
Source Source Link

Details

PrimaryID7424
RefseqGeneNG_034216
SymbolVEGFC
Namevascular endothelial growth factor C
Chromosome4
Location4q34.3
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-08-25
ModificationDate2021-06-13

Ontological Relatives

UniProt IDsVEGFC_HUMAN

GO terms

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GOName
GO:0001666 response to hypoxia
GO:0001934 positive regulation of protein phosphorylation
GO:0001938 positive regulation of endothelial cell proliferation
GO:0002040 sprouting angiogenesis
GO:0002052 positive regulation of neuroblast proliferation
GO:0002576 platelet degranulation
GO:0005172 vascular endothelial growth factor receptor binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0006929 substrate-dependent cell migration
GO:0007165 signal transduction
GO:0008083 growth factor activity
GO:0008284 positive regulation of cell population proliferation
GO:0009887 animal organ morphogenesis
GO:0016020 membrane
GO:0016331 morphogenesis of embryonic epithelium
GO:0030947 regulation of vascular endothelial growth factor receptor signaling pathway
GO:0031093 platelet alpha granule lumen
GO:0031954 positive regulation of protein autophosphorylation
GO:0038084 vascular endothelial growth factor signaling pathway
GO:0042056 chemoattractant activity
GO:0042493 response to drug
GO:0043185 vascular endothelial growth factor receptor 3 binding
GO:0043536 positive regulation of blood vessel endothelial cell migration
GO:0045668 negative regulation of osteoblast differentiation
GO:0045766 positive regulation of angiogenesis
GO:0045776 negative regulation of blood pressure
GO:0045860 positive regulation of protein kinase activity
GO:0048010 vascular endothelial growth factor receptor signaling pathway
GO:0050714 positive regulation of protein secretion
GO:0050930 induction of positive chemotaxis
GO:0051781 positive regulation of cell division
GO:0060754 positive regulation of mast cell chemotaxis
GO:1901492 positive regulation of lymphangiogenesis
GO:1902462 positive regulation of mesenchymal stem cell proliferation
GO:1990830 cellular response to leukemia inhibitory factor

Diseases

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Disease IDSourceNameDescription
615907 OMIMLymphatic malformation 4 (LMPHM4)A form of primary lymphedema, a disease characterized by swelling of body parts due to developmental anomalies and functional defects of the lymphatic system. Patients with lymphedema may suffer from recurrent local infections. LMPHM4 is an autosomal dominant form with onset at birth or in early childhood. Affected individuals manifest lymphedema of lower limbs with prominent veins, and impaired lymphatic uptake and drainage. Additional features are nail dysplasia, skin hyperkeratosis and papillomatosis. The disease is caused by variants affecting the gene represented in this entry.

Interactions

4 interactions

InteractorPartnerSourcesPublicationsLink
VEGFCSGTBBioGRID, IntAct32296183 details
VEGFCKDRBioGRID, DIP, HPRD11332691 18593464 20145116 details
VEGFCVEGFCBioGRID, HPRD20145116 9233800 details
VEGFCFLT4BioGRID, HPRD, IntAct16530705 21130043 8700872 details