Entity Details

Primary name WNT3
Entity type gene
Source Source Link

Details

PrimaryID7473
RefseqGeneNG_008084
SymbolWNT3
NameWnt family member 3
Chromosome17
Location17q21.31-q21.32
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1997-09-05
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsWNT3_HUMAN

GO terms

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GOName
GO:0000902 cell morphogenesis
GO:0001707 mesoderm formation
GO:0005109 frizzled binding
GO:0005125 cytokine activity
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005788 endoplasmic reticulum lumen
GO:0005796 Golgi lumen
GO:0005886 plasma membrane
GO:0007276 gamete generation
GO:0007411 axon guidance
GO:0009948 anterior/posterior axis specification
GO:0009950 dorsal/ventral axis specification
GO:0010628 positive regulation of gene expression
GO:0016055 Wnt signaling pathway
GO:0019904 protein domain specific binding
GO:0030177 positive regulation of Wnt signaling pathway
GO:0030182 neuron differentiation
GO:0030666 endocytic vesicle membrane
GO:0031012 extracellular matrix
GO:0035115 embryonic forelimb morphogenesis
GO:0035116 embryonic hindlimb morphogenesis
GO:0044338 canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation
GO:0044339 canonical Wnt signaling pathway involved in osteoblast differentiation
GO:0045165 cell fate commitment
GO:0048018 receptor ligand activity
GO:0048697 positive regulation of collateral sprouting in absence of injury
GO:0048843 negative regulation of axon extension involved in axon guidance
GO:0050767 regulation of neurogenesis
GO:0060064 Spemann organizer formation at the anterior end of the primitive streak
GO:0060070 canonical Wnt signaling pathway
GO:0060174 limb bud formation
GO:0060323 head morphogenesis
GO:0061180 mammary gland epithelium development
GO:0070062 extracellular exosome
GO:0071300 cellular response to retinoic acid
GO:0072089 stem cell proliferation
GO:1904954 canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation
GO:1905474 canonical Wnt signaling pathway involved in stem cell proliferation
GO:1990909 Wnt signalosome

Diseases

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Disease IDSourceNameDescription
273395 OMIMTetraamelia syndrome 1 (TETAMS1)A form of tetraamelia, a rare disease characterized by rudimentary appendages or complete absence of all four limbs, and other anomalies such as craniofacial, nervous system, pulmonary, skeletal and urogenital defects. TETAMS1 patients manifest complete limb agenesis without defects of scapulae or clavicles. Other features include bilateral cleft lip/palate, diaphragmatic defect with bilobar right lung, renal and adrenal agenesis, pelvic hypoplasia, and urogenital defects. TETAMS1 transmission pattern is consistent with autosomal recessive inheritance. The disease is caused by variants affecting the gene represented in this entry.

Interactions

5 interactions

InteractorPartnerSourcesPublicationsLink
WNT3AFMUniProt26902720 details
WNT3FZD7bhf-ucl, Molecular Connections18313787 21314951 details
WNT3FZD1HPRD10557084 details
WNT3WNT3ABioGRID, IntAct26186194 28514442 details
WNT3MKRN2BioGRID32460013 details