Entity Details

Primary name T4S20_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ53R12
EntryNameT4S20_HUMAN
FullNameTransmembrane 4 L6 family member 20
TaxID9606
Evidenceevidence at protein level
Length229
SequenceStatuscomplete
DateCreated2006-10-03
DateModified2021-06-02

Ontological Relatives

GenesTM4SF20

GO terms

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GOName
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0016021 integral component of membrane
GO:0045861 negative regulation of proteolysis

Subcellular Location

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Subcellular Location
Endoplasmic reticulum membrane
Membrane

Domains

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DomainNameCategoryType
IPR008661 L6 membraneFamilyFamily

Diseases

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Disease IDSourceNameDescription
615432 OMIMSpecific language impairment 5 (SLI5)A disorder characterized by a delay in early speech acquisition. It is usually associated with cerebral white matter abnormalities on brain MRI. Some individuals may show disorders in communication, consistent with autism spectrum disorder, or global developmental delay, although others ultimately show normal cognitive function. Penetrance is incomplete and expressivity is variable. The disease is caused by variants affecting the gene represented in this entry.

Interactions

5 interactions