Entity Details

Primary name TNI3K_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ59H18
EntryNameTNI3K_HUMAN
FullNameSerine/threonine-protein kinase TNNI3K
TaxID9606
Evidenceevidence at protein level
Length835
SequenceStatuscomplete
DateCreated2005-11-22
DateModified2021-06-02

Ontological Relatives

GO terms

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GOName
GO:0002027 regulation of heart rate
GO:0004672 protein kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0006468 protein phosphorylation
GO:0008022 protein C-terminus binding
GO:0031013 troponin I binding
GO:0046872 metal ion binding
GO:0055117 regulation of cardiac muscle contraction
GO:0086069 bundle of His cell to Purkinje myocyte communication
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1903779 regulation of cardiac conduction

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR002110 Ankyrin repeatRepeatRepeat
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR020683 Ankyrin repeat-containing domainDomainDomain
IPR036770 Ankyrin repeat-containing domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
616117 OMIMCardiac conduction disease with or without dilated cardiomyopathy (CCDD)A cardiac disorder characterized by atrial tachyarrhythmia and conduction system disease. Some patients have dilated cardiomyopathy. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB12010 FostamatinibDrugbanksmall molecule