Entity Details

Primary name DNAH11
Entity type gene
Source Source Link

Details

PrimaryID8701
RefseqGeneNG_012886
SymbolDNAH11
Namedynein axonemal heavy chain 11
Chromosome7
Location7p15.3
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2000-09-20
ModificationDate2021-06-22

Ontological Relatives

UniProt IDsDYH11_HUMAN

GO terms

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GOName
GO:0003341 cilium movement
GO:0003356 regulation of cilium beat frequency
GO:0005524 ATP binding
GO:0005874 microtubule
GO:0005930 axoneme
GO:0007018 microtubule-based movement
GO:0007368 determination of left/right symmetry
GO:0008569 minus-end-directed microtubule motor activity
GO:0030286 dynein complex
GO:0030317 flagellated sperm motility
GO:0031514 motile cilium
GO:0045505 dynein intermediate chain binding
GO:0051959 dynein light intermediate chain binding
GO:0097729 9+2 motile cilium
GO:0120134 proximal portion of axoneme

Diseases

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Disease IDSourceNameDescription
611884 OMIMCiliary dyskinesia, primary, 7 (CILD7)A disorder characterized by abnormalities of motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in the respiratory cilia; reduced fertility is often observed in male patients due to abnormalities of sperm tails. Half of the patients exhibit randomization of left-right body asymmetry and situs inversus, due to dysfunction of monocilia at the embryonic node. Primary ciliary dyskinesia associated with situs inversus is referred to as Kartagener syndrome. The disease is caused by variants affecting the gene represented in this entry.

Interactions

3 interactions

InteractorPartnerSourcesPublicationsLink
DNAH11ZDHHC17BioGRID24705354 details
DNAH11ANLNBioGRID31586073 details
DNAH11NR3C1BioGRID31182584 details