Entity Details

Primary name RIPK1
Entity type gene
Source Source Link

Details

PrimaryID8737
RefseqGeneNG_063914
SymbolRIPK1
Namereceptor interacting serine/threonine kinase 1
Chromosome6
Location6p25.2
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1999-05-07
ModificationDate2021-06-22

Ontological Relatives

UniProt IDsRIPK1_HUMAN

GO terms

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GOName
GO:0001934 positive regulation of protein phosphorylation
GO:0002756 MyD88-independent toll-like receptor signaling pathway
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004706 JUN kinase kinase kinase activity
GO:0005123 death receptor binding
GO:0005524 ATP binding
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006915 apoptotic process
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006954 inflammatory response
GO:0007249 I-kappaB kinase/NF-kappaB signaling
GO:0007257 obsolete activation of JUN kinase activity
GO:0008219 cell death
GO:0010008 endosome membrane
GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway
GO:0010940 positive regulation of necrotic cell death
GO:0016579 protein deubiquitination
GO:0019054 modulation by virus of host cellular process
GO:0031264 death-inducing signaling complex
GO:0031625 ubiquitin protein ligase binding
GO:0032757 positive regulation of interleukin-8 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0032991 protein-containing complex
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0034138 toll-like receptor 3 signaling pathway
GO:0034612 response to tumor necrosis factor
GO:0035666 TRIF-dependent toll-like receptor signaling pathway
GO:0036289 peptidyl-serine autophosphorylation
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043068 positive regulation of programmed cell death
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043235 receptor complex
GO:0044257 cellular protein catabolic process
GO:0044877 protein-containing complex binding
GO:0045121 membrane raft
GO:0045651 positive regulation of macrophage differentiation
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046330 positive regulation of JNK cascade
GO:0046777 protein autophosphorylation
GO:0050729 positive regulation of inflammatory response
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0060544 regulation of necroptotic process
GO:0060545 positive regulation of necroptotic process
GO:0060546 negative regulation of necroptotic process
GO:0062099 negative regulation of programmed necrotic cell death
GO:0070105 positive regulation of interleukin-6-mediated signaling pathway
GO:0070231 T cell apoptotic process
GO:0070266 necroptotic process
GO:0070301 cellular response to hydrogen peroxide
GO:0070513 death domain binding
GO:0070926 regulation of ATP:ADP antiporter activity
GO:0071356 cellular response to tumor necrosis factor
GO:0071550 death-inducing signaling complex assembly
GO:0097190 apoptotic signaling pathway
GO:0097191 extrinsic apoptotic signaling pathway
GO:0097300 programmed necrotic cell death
GO:0097342 ripoptosome
GO:0097343 ripoptosome assembly
GO:0097527 necroptotic signaling pathway
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1902041 regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1903800 positive regulation of production of miRNAs involved in gene silencing by miRNA
GO:1905206 positive regulation of hydrogen peroxide-induced cell death
GO:1990000 amyloid fibril formation
GO:2000379 positive regulation of reactive oxygen species metabolic process
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway
GO:2001238 positive regulation of extrinsic apoptotic signaling pathway

Diseases

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Disease IDSourceNameDescription
618852 OMIMAutoinflammation with episodic fever and lymphadenopathy (AIEFL)An autosomal dominant immunologic disorder characterized by early onset of recurrent episodes of unexplained fever, lymphadenopathy, hepatosplenomegaly, and increased levels of inflammatory cytokines and chemokines in patient serum. The disease is caused by variants affecting the gene represented in this entry.
618108 OMIMImmunodeficiency 57 with autoinflammation (IMD57)An autosomal recessive primary immunodeficiency characterized by lymphopenia and recurrent viral, bacterial, and fungal infections. Patients exhibit early-onset inflammatory bowel disease involving the upper and lower gastrointestinal tract, and develop progressive polyarthritis. The disease is caused by variants affecting the gene represented in this entry. RIPK1-deficient immune cells from IMD57 patients have impaired proinflammatory signaling leading to dysregulated cytokine secretion and are prone to necroptosis.

Interactions

151 interactions

InteractorPartnerSourcesPublicationsLink
RIPK1IKBKGBioGRID, HPRD, I2D, InnateDB, IntAct, MINT10755617 10880512 10980203 11262391 14653779 16543241 16547522 16603398 17702576 18029035 18212736 19373245 21113135 21383699 21458669 21606198 22099304 23104095 23746843 24735611 26740240 26802121 26865630 27929056 28249776 30561431 31502302 32024692 details
RIPK1TRAF3BioGRID, HPRD, IntAct, MINT32296183 8612133 details
RIPK1TRAF2BioGRID, HPRD, IntAct, MINT, UniProt11181075 11479302 16291755 16603398 19815541 20577214 21282461 21810480 23007157 23972990 24434549 24735611 25416956 25716317 25882049 27768232 29352166 30561431 31502302 32296183 8612133 8702708 9020361 details
RIPK1TRAF1BioGRID, HPRD, IntAct, MINT19287455 25416956 32296183 8612133 details
RIPK1TRADDBioGRID, HPRD, IntAct, MINT16603398 21724995 23429285 24735611 27768232 30561431 8612133 details
RIPK1TRIM38HPRD, MINT11854271 details
RIPK1RIPK1BioGRID, DIP, HPRD, IntAct14743216 15001576 15175328 22817896 23473668 25416956 27045108 31980649 32296183 details
RIPK1TNFBioGRID, DIP, InnateDB, IntAct, MINT12753742 12887920 16603398 20005846 21331077 21620750 22028622 22099304 22675546 23032187 23104095 23815148 23955153 24726327 24980434 25911380 26670046 27307491 27458237 27545878 27560715 30420664 31898971 details
RIPK1CASP8BioGRID, DIP, HPRD, IntAct, MINT10521396 11002417 12215447 12884866 12887920 17047155 18485876 18570872 19060883 19373245 19524512 19524513 19773432 20825417 21282461 21458669 21525013 21737329 21737330 22173242 22179575 22274400 22585859 22864571 23429285 23955153 23972990 24098568 24577083 25911380 25939870 26733177 26972597 27552911 27810922 29021293 29274253 29431638 33052227 details
RIPK1FASBioGRID, HPRD, IntAct7538908 9740801 details
RIPK1TNFRSF1ABioGRID, HPRD, IntAct, UniProt11002422 15258597 16115877 16611992 16968706 18022363 18450452 18621737 18724939 18939944 18949366 19524513 19773432 19781631 19815541 20448643 20825417 21113135 21331078 21737329 22179575 22733818 22817896 22848449 23429285 24098568 24130170 24758719 25388546 25681446 26802121 27321185 27552911 27591049 28388439 28514442 28817177 29431638 30420664 31406107 8612133 8985253 details
RIPK1CSNK1A1UniProt18067272 details
RIPK1RIPK3BioGRID, HPIDb, HPRD, IntAct10339433 19524512 19524513 21903422 22265413 22265414 22817896 22864571 23744296 24098568 25882049 26319693 26559832 26786097 29352166 29497034 29883609 30420664 31358971 details
RIPK1FADDBioGRID, HPRD, IntAct11002422 11854271 19373245 19524513 21052097 21183682 21458669 21525013 21620750 21737329 22848449 22864571 23744296 23972990 24098568 24577083 26186194 26733177 26865630 26972597 27560715 29497034 30561431 32024820 32296183 details
RIPK1CDC42BPBBioGRID, IntAct20936779 details
RIPK1NUMBLBioGRID, IntAct21988832 details
RIPK1BIRC2BioGRID, IntAct18570872 19854138 21113135 21931591 23972990 26612615 27197231 29021293 29955050 30561431 details
RIPK1XIAPBioGRID, IntAct21931591 29955050 details
RIPK1BIRC3BioGRID, IntAct16547522 18570872 21113135 21931591 23972990 details
RIPK1ZBP1IntAct22817896 details
RIPK1DAXXMINT23260419 details
RIPK1TNFAIP3BioGRID, HPRD, IntAct15258597 18246070 19131965 22585859 29274253 30561431 32015333 details
RIPK1CRADDBioGRID, HPRD8985253 9044836 details
RIPK1RNF216BioGRID, HPRD11854271 16968706 27995769 details
RIPK1SQSTM1BioGRID, HPRD10356400 26416459 details
RIPK1PELI1BioGRID19734906 33052227 details
RIPK1OPTNBioGRID17702576 21408173 22675546 27552911 details
RIPK1KHDRBS1BioGRID21620750 details
RIPK1USP2BioGRID22179575 22659130 details
RIPK1IKBKBBioGRID10980203 21606198 details
RIPK1UBE2NBioGRID18029035 details
RIPK1YOD1BioGRID23827681 details
RIPK1OTUD1BioGRID23827681 details
RIPK1RFFLBioGRID18450452 details
RIPK1PRKNBioGRID29955050 details
RIPK1USP20BioGRID30354204 details
RIPK1TBK1BioGRID30420664 details
RIPK1IKBKEBioGRID30420664 details
RIPK1HSPA1LIntAct14743216 details
RIPK1HSPA5IntAct14743216 details
RIPK1HSPA8IntAct14743216 details
RIPK1SLC25A5IntAct14743216 details
RIPK1HSPA9IntAct14743216 details
RIPK1RPL23IntAct14743216 details
RIPK1DNAJA1IntAct14743216 details
RIPK1CADIntAct14743216 details
RIPK1ACTG1IntAct14743216 details
RIPK1TIMM50IntAct14743216 details
RIPK1RCN2IntAct14743216 details
RIPK1TUBBIntAct14743216 details
RIPK1TUBB4AIntAct14743216 details
RIPK1HSP90AA1BioGRID, HPRD, IntAct10744744 14743216 16968706 22939624 details
RIPK1TUBA3DIntAct14743216 details
RIPK1TUBA3CIntAct14743216 details
RIPK1HSP90AB1IntAct14743216 22939624 details
RIPK1PIDD1BioGRID, MINT16360037 17159900 details
RIPK1CCDC50BioGRID, HPRD, IntAct18029035 1802935 details
RIPK1ANXA1BioGRID, I2D21383699 29021293 details
RIPK1CFLARBioGRID, HPRD, IntAct10837247 11002417 17047155 21737330 26972597 details
RIPK1CASP10BioGRID, IntAct11002417 12884866 details
RIPK1USP4BioGRID, MINT21331078 23313255 details
RIPK1LRRK2BioGRID, IntAct19176810 details
RIPK1CDC37IntAct25036637 details
RIPK1PYCARDBioGRID, IntAct25402006 details
RIPK1CARD6DIP16418290 details
RIPK1TICAM1BioGRID, HPRD15064760 19734906 25736436 33052227 details
RIPK1TRPC4APBioGRID, HPRD14585990 details
RIPK1TNFRSF10BBioGRID, HPRD22585859 32313199 9430227 details
RIPK1TRAF5BioGRID, HPRD11479302 29955050 details
RIPK1EGFRBioGRID, HPRD11116146 details
RIPK1MAP3K14BioGRID, HPRD11116146 details
RIPK1RNF11BioGRID, HPRD19131965 details
RIPK1TAX1BP1BioGRID, HPRD18246070 19131965 details
RIPK1ITCHBioGRID, HPRD19131965 details
RIPK1MAP3K7BioGRID16543241 18570872 21606198 24434549 details
RIPK1TAB2BioGRID15327770 16603398 18299187 29955050 details
RIPK1CYLDBioGRID17981138 21408173 22848449 28900035 details
RIPK1USP21BioGRID19910467 details
RIPK1TNFRSF25BioGRID21421854 details
RIPK1NOD2BioGRID22607974 details
RIPK1RIPK2BioGRID22607974 details
RIPK1RBCK1BioGRID17449468 29955050 details
RIPK1TLR3BioGRID16115877 27810922 details
RIPK1CLIP3BioGRID22297296 details
RIPK1MAP3K3BioGRID, HPRD11429546 details
RIPK1DAB2IPBioGRID15310755 17389591 details
RIPK1TNFRSF1BBioGRID19287455 details
RIPK1CHUKBioGRID10980203 29955050 details
RIPK1TNFSF10BioGRID19432816 22585859 details
RIPK1MAP3K8BioGRID, HPRD16291755 details
RIPK1UBCBioGRID25423073 25715336 26017671 details
RIPK1EGLN3BioGRID26612615 26972000 details
RIPK1RNF31BioGRID26670046 29955050 details
RIPK1ERN1BioGRID25476903 details
RIPK1TRIM27BioGRID24144979 details
RIPK1MLKLBioGRID27560715 details
RIPK1XAF1BioGRID27768232 details
RIPK1WDR48BioGRID29138248 details
RIPK1USP1BioGRID29138248 details
RIPK1ANGPTL8BioGRID29255244 details
RIPK1CBLBioGRID29891719 details
RIPK1ATG5BioGRID23744296 details
RIPK1USP15BioGRID31903660 details
RIPK1PRKCZBioGRID32354117 details
RIPK1TNFRSF10AHPRD9430227 details
RIPK1ZFAND5HPRD14754897 details
RIPK1NFKB1HPRD16291755 details
RIPK1PGAM5IntAct22265414 details
RIPK1LTAMINT23815148 details
RIPK1HSCBBioGRID, IntAct28380382 details
RIPK1THSD4BioGRID, IntAct28514442 details
RIPK1MLF1BioGRID, IntAct26186194 28514442 details
RIPK1GPX7BioGRID, IntAct28514442 details
RIPK1ATG7BioGRID, IntAct28514442 details
RIPK1NTAN1BioGRID, IntAct26186194 28514442 details
RIPK1TNIP2BioGRID, IntAct30561431 details
RIPK1PHLDA1BioGRID, IntAct31980649 details
RIPK1TAF4BioGRID, IntAct31980649 details
RIPK1HNRNPRBioGRID, IntAct31980649 details
RIPK1BAG2BioGRID, IntAct31980649 details
RIPK1P4HBBioGRID, IntAct31980649 details
RIPK1RPSABioGRID, IntAct31980649 details
RIPK1S100A4BioGRID, IntAct31980649 details
RIPK1TPP2BioGRID, IntAct31980649 details
RIPK1SNRPD1BioGRID, IntAct31980649 details
RIPK1SNRPD2BioGRID, IntAct31980649 details
RIPK1RPS27ABioGRID, IntAct31980649 details
RIPK1RPS21BioGRID, IntAct31980649 details
RIPK1CSNK2A1BioGRID, IntAct31980649 details
RIPK1CSNK2A3BioGRID, IntAct31980649 details
RIPK1CCAR2BioGRID, IntAct31980649 details
RIPK1RP9BioGRID, IntAct31980649 details
RIPK1PRMT1BioGRID, IntAct31980649 details
RIPK1SLC4A1APBioGRID, IntAct31980649 details
RIPK1ARGLU1BioGRID, IntAct31980649 details
RIPK1SRRM2BioGRID, IntAct31980649 details
RIPK1MRPS17BioGRID, IntAct31980649 details
RIPK1HSPB1BioGRID, IntAct31980649 details
RIPK1ABCE1BioGRID, IntAct31980649 details
RIPK1MRPS6BioGRID, IntAct31980649 details
RIPK1THRAP3BioGRID, IntAct31980649 details
RIPK1FGL1BioGRID26186194 details
RIPK1HERC2BioGRID26186194 details
RIPK1AP1M2BioGRID26186194 details
RIPK1XPO1BioGRID26673895 details
RIPK1COX5ABioGRID29955050 details
RIPK1TAB1BioGRID29955050 details
RIPK1NHLRC2BioGRID30397336 details
RIPK1CITBioGRID31586073 details
RIPK1TP53IntAct25857266 details
RIPK1MTDHBioGRID22199357 details