Entity Details

Primary name RIPK2
Entity type gene
Source Source Link

Details

PrimaryID8767
RefseqGeneNG_033016
SymbolRIPK2
Namereceptor interacting serine/threonine kinase 2
Chromosome8
Location8q21.3
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1999-05-07
ModificationDate2021-06-22

Ontological Relatives

UniProt IDsRIPK2_HUMAN

GO terms

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GOName
GO:0000187 obsolete activation of MAPK activity
GO:0001961 positive regulation of cytokine-mediated signaling pathway
GO:0002250 adaptive immune response
GO:0002827 positive regulation of T-helper 1 type immune response
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004706 JUN kinase kinase kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005102 signaling receptor binding
GO:0005524 ATP binding
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0006915 apoptotic process
GO:0006954 inflammatory response
GO:0007165 signal transduction
GO:0007249 I-kappaB kinase/NF-kappaB signaling
GO:0007254 JNK cascade
GO:0007257 obsolete activation of JUN kinase activity
GO:0010800 positive regulation of peptidyl-threonine phosphorylation
GO:0010942 positive regulation of cell death
GO:0030274 LIM domain binding
GO:0031398 positive regulation of protein ubiquitination
GO:0031663 lipopolysaccharide-mediated signaling pathway
GO:0031982 vesicle
GO:0032092 positive regulation of protein binding
GO:0032722 positive regulation of chemokine production
GO:0032727 positive regulation of interferon-alpha production
GO:0032728 positive regulation of interferon-beta production
GO:0032729 positive regulation of interferon-gamma production
GO:0032731 positive regulation of interleukin-1 beta production
GO:0032735 positive regulation of interleukin-12 production
GO:0032743 positive regulation of interleukin-2 production
GO:0032755 positive regulation of interleukin-6 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0032991 protein-containing complex
GO:0033091 positive regulation of immature T cell proliferation
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0034134 toll-like receptor 2 signaling pathway
GO:0034142 toll-like receptor 4 signaling pathway
GO:0042098 T cell proliferation
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043330 response to exogenous dsRNA
GO:0045087 innate immune response
GO:0045627 positive regulation of T-helper 1 cell differentiation
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046330 positive regulation of JNK cascade
GO:0046641 positive regulation of alpha-beta T cell proliferation
GO:0050700 CARD domain binding
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050830 defense response to Gram-positive bacterium
GO:0050852 T cell receptor signaling pathway
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070423 nucleotide-binding oligomerization domain containing signaling pathway
GO:0070427 nucleotide-binding oligomerization domain containing 1 signaling pathway
GO:0070431 nucleotide-binding oligomerization domain containing 2 signaling pathway
GO:0070498 interleukin-1-mediated signaling pathway
GO:0070671 response to interleukin-12
GO:0070673 response to interleukin-18
GO:0071223 cellular response to lipoteichoic acid
GO:0071224 cellular response to peptidoglycan
GO:0071225 cellular response to muramyl dipeptide
GO:0089720 caspase binding
GO:0097202 activation of cysteine-type endopeptidase activity
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1904417 positive regulation of xenophagy

Diseases

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Interactions

94 interactions

InteractorPartnerSourcesPublicationsLink
RIPK2NOD1BioGRID, HPRD, IntAct, MINT, UniProt10224040 10329646 12459189 16517750 17054981 23300079 29997244 details
RIPK2NOD2BioGRID, HPRD, IntAct, MINT11087742 15620648 19592251 21097508 21123652 21931826 22607974 22829933 26670046 27545878 27812135 details
RIPK2RIPK2BioGRID, IntAct14743216 21123652 25416956 27045108 32296183 details
RIPK2UBE2IBioGRID, HPRD, IntAct16189514 details
RIPK2BIRC2BioGRID, HPRD, IntAct19464198 21931591 30026309 9642260 9705938 details
RIPK2XIAPBioGRID, DIP, IntAct19667203 21931591 22607974 22815893 23818254 25416956 29452636 30026309 31515488 details
RIPK2BIRC3BioGRID, IntAct19464198 21931591 9705938 details
RIPK2MAVSBioGRID, IntAct21903422 details
RIPK2KDM3ABioGRID, MINT23455924 details
RIPK2PRMT2BioGRID, MINT23455924 details
RIPK2TRAF3BioGRID, I2D23333941 details
RIPK2LRRK2BioGRID20949042 details
RIPK2CHUKBioGRID22547678 details
RIPK2PELI3BioGRID23892723 details
RIPK2ZNRF4BioGRID28656966 details
RIPK2IKBKGBioGRID, HPRD, MINT10880512 18079694 details
RIPK2TRAF1BioGRID, HPRD, MINT9705938 details
RIPK2CASP1BioGRID, HPRD, MINT9705938 details
RIPK2TRAF2BioGRID, HPRD, IntAct, MINT21903422 9705938 details
RIPK2HSPA1LIntAct14743216 details
RIPK2HSPA8IntAct14743216 details
RIPK2HSPA2IntAct14743216 details
RIPK2HSPA6IntAct14743216 details
RIPK2MYH10IntAct14743216 details
RIPK2ACTG1IntAct14743216 details
RIPK2HADHBIntAct14743216 details
RIPK2GEMIN4IntAct14743216 details
RIPK2TUBB2BIntAct14743216 details
RIPK2CALM1IntAct14743216 details
RIPK2CALM2IntAct14743216 details
RIPK2CALM3IntAct14743216 details
RIPK2TUBBIntAct14743216 details
RIPK2TUBB4AIntAct14743216 details
RIPK2MYH9IntAct14743216 details
RIPK2ENO1IntAct14743216 details
RIPK2VIMBioGRID, IntAct14743216 34079125 details
RIPK2HSP90AA1IntAct14743216 details
RIPK2GAPDHIntAct14743216 details
RIPK2TUBA3DIntAct14743216 details
RIPK2TUBA3CIntAct14743216 details
RIPK2MYO1DIntAct14743216 details
RIPK2ATP5F1DIntAct17353931 details
RIPK2ECHS1IntAct17353931 details
RIPK2GXYLT1IntAct17353931 details
RIPK2PCMT1IntAct17353931 details
RIPK2FABP5IntAct17353931 details
RIPK2KIF14IntAct17353931 details
RIPK2SOD2IntAct17353931 details
RIPK2RPL36IntAct17353931 details
RIPK2PSMB5IntAct17353931 details
RIPK2PSMA7IntAct17353931 details
RIPK2EZRIntAct17353931 details
RIPK2PSMA6IntAct17353931 details
RIPK2HNRNPA3IntAct17353931 details
RIPK2NFATC2IntAct17353931 details
RIPK2CARD6BioGRID, DIP, HPRD12775719 16418290 details
RIPK2CFLARBioGRID, HPRD9575181 details
RIPK2TRAF5BioGRID, HPRD9642260 details
RIPK2TRAF6BioGRID, HPRD18329614 21097508 9642260 details
RIPK2TNFRSF1ABioGRID, HPRD9642260 details
RIPK2CD40BioGRID, HPRD9642260 details
RIPK2MAP3K7BioGRID17348859 17947236 17965022 18079694 details
RIPK2TAB1BioGRID18079694 details
RIPK2TAB2BioGRID18079694 details
RIPK2NAT16BioGRID22607974 details
RIPK2RIPK1BioGRID22607974 details
RIPK2RNF31BioGRID22607974 details
RIPK2CASP12BioGRID18329614 details
RIPK2MAP3K4BioGRID21097508 details
RIPK2TRAF4BioGRID21097508 details
RIPK2UBCBioGRID23437331 details
RIPK2CARD16BioGRID, HPRD11432859 11536016 details
RIPK2IRF4BioGRID24670424 details
RIPK2NGFRBioGRID, HPRD11487608 16498402 details
RIPK2ATG16L1BioGRID32909611 details
RIPK2TLR2BioGRID, HPRD11894098 32909611 details
RIPK2CASP8HPRD9575181 details
RIPK2SMAD4HPRD15761153 details
RIPK2SMURF1HPRD15761153 details
RIPK2IRAK1HPRD15691841 details
RIPK2TLR4HPRD15691841 details
RIPK2BCL10HPRD14638696 details
RIPK2KCTD12BioGRID, IntAct17353931 details
RIPK2PHB2BioGRID, IntAct17353931 details
RIPK2RPL38BioGRID, IntAct17353931 details
RIPK2RPS14BioGRID, IntAct17353931 details
RIPK2CEP43BioGRID, IntAct26638075 details
RIPK2TRIM14BioGRID29053956 details
RIPK2CLTABioGRID34079125 details
RIPK2PRPHBioGRID34079125 details
RIPK2SQSTM1BioGRID34079125 details
RIPK2SHMT2BioGRID22658674 details
RIPK2MOV10BioGRID22658674 details
RIPK2NXF1BioGRID22658674 details