Entity Details

Primary name CCN6
Entity type gene
Source Source Link

Details

PrimaryID8838
RefseqGeneNG_011748
SymbolCCN6
Namecellular communication network factor 6
Chromosome6
Location6q21
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1999-01-28
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsCCN6_HUMAN

GO terms

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GOName
GO:0005178 integrin binding
GO:0005520 insulin-like growth factor binding
GO:0005615 extracellular space
GO:0005739 mitochondrion
GO:0007155 cell adhesion
GO:0007165 signal transduction
GO:0007267 cell-cell signaling
GO:0008083 growth factor activity
GO:0008201 heparin binding
GO:0008285 negative regulation of cell population proliferation
GO:0016525 negative regulation of angiogenesis
GO:0031012 extracellular matrix
GO:0051881 regulation of mitochondrial membrane potential
GO:0060548 negative regulation of cell death
GO:1903426 regulation of reactive oxygen species biosynthetic process

Diseases

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Disease IDSourceNameDescription
208230 OMIMProgressive pseudorheumatoid arthropathy of childhood (PPAC)Autosomal recessive disorder characterized by stiffness and swelling of joints, motor weakness and joint contractures. Signs and symptoms of the disease develop typically between three and eight years of age. This progressive disease is a primary disorder of articular cartilage with continued cartilage loss and destructive bone changes with aging. The disease is caused by variants affecting the gene represented in this entry.

Interactions

6 interactions

InteractorPartnerSourcesPublicationsLink
CCN6DDX47BioGRID, IntAct26186194 28514442 details
CCN6APBB2BioGRID, IntAct26186194 28514442 details
CCN6CRELD2BioGRID, IntAct26186194 28514442 details
CCN6POLR2DBioGRID, IntAct28514442 details
CCN6SCARB2BioGRID26186194 details
CCN6SORL1BioGRID26186194 details