Entity Details

Primary name CACNA2D2
Entity type gene
Source Source Link

Details

PrimaryID9254
RefseqGeneNG_034070
SymbolCACNA2D2
Namecalcium voltage-gated channel auxiliary subunit alpha2delta 2
Chromosome3
Location3p21.31
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1999-06-11
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsCA2D2_HUMAN

GO terms

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GOName
GO:0005245 voltage-gated calcium channel activity
GO:0005886 plasma membrane
GO:0005891 voltage-gated calcium channel complex
GO:0034765 regulation of ion transmembrane transport
GO:0046872 metal ion binding
GO:0050796 regulation of insulin secretion
GO:0061337 cardiac conduction

Diseases

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Disease IDSourceNameDescription
618501 OMIMCerebellar atrophy with seizures and variable developmental delay (CASVDD)An autosomal recessive neurologic disorder characterized by cerebellar ataxia, atrophy of the cerebellar vermis, severe refractory seizures with early onset, and global developmental delay compatible with epileptic encephalopathy in most patients. Disease severity is variable and normal cognitive development has also been reported. The disease is caused by variants affecting the gene represented in this entry.