Entity Details

Primary name KLK4
Entity type gene
Source Source Link

Details

PrimaryID9622
RefseqGeneNG_012154
SymbolKLK4
Namekallikrein related peptidase 4
Chromosome19
Location19q13.41
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2000-03-17
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsKLK4_HUMAN

GO terms

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GOName
GO:0004252 serine-type endopeptidase activity
GO:0005576 extracellular region
GO:0006508 proteolysis
GO:0008236 serine-type peptidase activity
GO:0022617 extracellular matrix disassembly
GO:0030141 secretory granule
GO:0031214 biomineral tissue development
GO:0046872 metal ion binding
GO:0097186 amelogenesis

Diseases

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Disease IDSourceNameDescription
204700 OMIMAmelogenesis imperfecta, hypomaturation type, 2A1 (AI2A1)A defect of enamel formation. The disorder involves both primary and secondary dentitions. The teeth have a shiny agar jelly appearance and the enamel is softer than normal. Brown pigment is present in middle layers of enamel. The disease is caused by variants affecting the gene represented in this entry.

Interactions

7 interactions

InteractorPartnerSourcesPublicationsLink
KLK4TYRO3BioGRID, IntAct25416956 details
KLK4SPINK2IntAct31391482 details
KLK4SHBGBioGRID, HPRD15862967 details
KLK4SERPINA3HPRD11735417 details
KLK4HLA-DRABioGRID, IntAct26186194 28514442 details
KLK4KCNIP4BioGRID, IntAct28514442 details
KLK4HNRNPLBioGRID28611215 details