Entity Details

Primary name CDC6
Entity type gene
Source Source Link

Details

PrimaryID990
RefseqGeneNG_028240
SymbolCDC6
Namecell division cycle 6
Chromosome17
Location17q21.2
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1999-08-03
ModificationDate2021-06-20

Ontological Relatives

UniProt IDsCDC6_HUMAN

GO terms

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GOName
GO:0000076 DNA replication checkpoint signaling
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle
GO:0000166 nucleotide binding
GO:0000278 mitotic cell cycle
GO:0000922 spindle pole
GO:0003688 DNA replication origin binding
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006260 DNA replication
GO:0006270 DNA replication initiation
GO:0007089 traversing start control point of mitotic cell cycle
GO:0008156 negative regulation of DNA replication
GO:0008285 negative regulation of cell population proliferation
GO:0019900 kinase binding
GO:0030071 regulation of mitotic metaphase/anaphase transition
GO:0032467 positive regulation of cytokinesis
GO:0033314 mitotic DNA replication checkpoint signaling
GO:0036388 pre-replicative complex assembly
GO:0045171 intercellular bridge
GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0048146 positive regulation of fibroblast proliferation
GO:0051233 spindle midzone
GO:0051301 cell division
GO:0051984 positive regulation of chromosome segregation
GO:0072686 mitotic spindle
GO:1904117 cellular response to vasopressin
GO:1904385 cellular response to angiotensin

Diseases

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Disease IDSourceNameDescription
613805 OMIMMeier-Gorlin syndrome 5 (MGORS5)A syndrome characterized by bilateral microtia, aplasia/hypoplasia of the patellae, and severe intrauterine and postnatal growth retardation with short stature and poor weight gain. Additional clinical findings include anomalies of cranial sutures, microcephaly, apparently low-set and simple ears, microstomia, full lips, highly arched or cleft palate, micrognathia, genitourinary tract anomalies, and various skeletal anomalies. While almost all cases have primordial dwarfism with substantial prenatal and postnatal growth retardation, not all cases have microcephaly, and microtia and absent/hypoplastic patella are absent in some. Despite the presence of microcephaly, intellect is usually normal. The disease is caused by variants affecting the gene represented in this entry.

Interactions

86 interactions

InteractorPartnerSourcesPublicationsLink
CDC6ORC1BioGRID, HPRD, IntAct12614612 12912926 15232106 9566895 details
CDC6ORC2BioGRID, HPRD, IntAct11046155 12614612 15232106 details
CDC6MCM10BioGRID, HPRD, IntAct15232106 details
CDC6MCM2BioGRID, HPRD, IntAct15232106 23405012 details
CDC6ORC5BioGRID, HPRD, IntAct15232106 details
CDC6ORC3BioGRID, HPRD, IntAct15232106 details
CDC6ORC6BioGRID, HPRD, IntAct15232106 details
CDC6CDKN2ABioGRID, HPRD, IntAct15232106 details
CDC6CDKN1ABioGRID, HPRD, IntAct15232106 25241761 details
CDC6CDT1BioGRID, HPRD, IntAct14672932 15232106 18162579 25990725 details
CDC6MCM3BioGRID, HPRD, IntAct10464337 11046155 15232106 details
CDC6UBE2KBioGRID, IntAct21988832 details
CDC6B3GALNT1BioGRID, IntAct21988832 details
CDC6CDK4BioGRID, IntAct22094256 details
CDC6CDK6BioGRID, IntAct22094256 details
CDC6MCM7BioGRID, HPRD, IntAct10464337 12614612 23397142 23405012 25990725 details
CDC6CDK1BioGRID, DIP10339564 21041660 details
CDC6PLK1DIP21041660 details
CDC6PPP2R3BBioGRID, HPRD10629059 details
CDC6PSKH1BioGRID, HPRD9889196 details
CDC6CCNA2BioGRID, HPRD10339564 9566895 9889196 details
CDC6MYCBioGRID, HPRD10899308 details
CDC6CDK2BioGRID, HPRD10339564 9566895 9889196 details
CDC6PCNABioGRID, HPRD9566895 details
CDC6PPP2R3ABioGRID, HPRD10629059 18397887 details
CDC6HUWE1BioGRID17567951 details
CDC6TERF1BioGRID18761675 details
CDC6ATRBioGRID20048340 details
CDC6ATMBioGRID20048340 details
CDC6ATRIPBioGRID20048340 details
CDC6KAT7BioGRID16428461 details
CDC6FZR1BioGRID10995389 14701726 21768287 details
CDC6CDC20BioGRID14701726 details
CDC6CCNE1BioGRID10339564 details
CDC6CCNB1BioGRID10339564 details
CDC6CDC14ABioGRID22117071 details
CDC6UBR1BioGRID8505328 details
CDC6CCNFBioGRID26818844 details
CDC6GRWD1BioGRID25990725 29991511 details
CDC6SQSTM1BioGRID29507222 details
CDC6OGTBioGRID32994395 details
CDC6UBBIntAct10995389 details
CDC6E2F1IntAct23397142 details
CDC6MCM6IntAct23397142 details
CDC6TTC4IntAct18320024 details
CDC6AKAP8LBioGRID, HPRD12538639 details
CDC6MCM8BioGRID15684404 details
CDC6BMI1BioGRID19462008 details
CDC6CCL2BioGRID21383955 details
CDC6HIF1ABioGRID23405012 details
CDC6MCM5BioGRID23405012 details
CDC6RPS27AHPRD10995389 details
CDC6MAPK6BioGRID, IntAct26972000 details
CDC6NOP56BioGRID, IntAct26496610 details
CDC6BPNT1BioGRID, IntAct28514442 details
CDC6MANSC1BioGRID, IntAct28514442 details
CDC6MAGEA10BioGRID, IntAct28514442 details
CDC6TNFRSF10ABioGRID, IntAct28514442 details
CDC6TSPAN3BioGRID, IntAct26186194 28514442 details
CDC6LAMP3BioGRID, IntAct28514442 details
CDC6GLMPBioGRID, IntAct28514442 details
CDC6ISLRBioGRID, IntAct26186194 28514442 details
CDC6IL20RABioGRID, IntAct28514442 details
CDC6LAMP2BioGRID, IntAct28514442 details
CDC6PROZBioGRID, IntAct28514442 details
CDC6PCDHB11BioGRID, IntAct28514442 details
CDC6TGFBR2BioGRID, IntAct26186194 28514442 details
CDC6PCDHGA5BioGRID, IntAct28514442 details
CDC6FAM131BBioGRID, IntAct28514442 details
CDC6TNFRSF1ABioGRID, IntAct28514442 details
CDC6TNFRSF8BioGRID, IntAct28514442 details
CDC6PON2BioGRID, IntAct26186194 28514442 details
CDC6TANKBioGRID, IntAct30561431 details
CDC6COLEC11BioGRID26186194 details
CDC6POLA1BioGRID26344197 details
CDC6HEY1BioGRID27129302 details
CDC6H4C1BioGRID30804502 details
CDC6CDC6BioGRID31160578 details
CDC6DDX39BBioGRID31160578 details
CDC6LRWD1BioGRID31160578 details
CDC6DDX5BioGRID31160578 details
CDC6PLEKHA4BioGRID31091453 details
CDC6TP53BioGRID32807901 details
CDC6KDM4CIntAct22078878 details
CDC6CDCA7LIntAct22078878 details
CDC6CBX4IntAct22078878 details