Entity Details

Primary name KCNE2
Entity type gene
Source Source Link

Details

PrimaryID9992
RefseqGeneNG_008804
SymbolKCNE2
Namepotassium voltage-gated channel subfamily E regulatory subunit 2
Chromosome21
Location21q22.11
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1999-05-11
ModificationDate2021-06-22

Ontological Relatives

UniProt IDsKCNE2_HUMAN

GO terms

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GOName
GO:0005242 inward rectifier potassium channel activity
GO:0005251 delayed rectifier potassium channel activity
GO:0005764 lysosome
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0007568 aging
GO:0008076 voltage-gated potassium channel complex
GO:0009986 cell surface
GO:0015459 potassium channel regulator activity
GO:0035690 cellular response to drug
GO:0042802 identical protein binding
GO:0043586 tongue development
GO:0044325 transmembrane transporter binding
GO:0060306 regulation of membrane repolarization
GO:0060307 regulation of ventricular cardiac muscle cell membrane repolarization
GO:0061337 cardiac conduction
GO:0071805 potassium ion transmembrane transport
GO:0086002 cardiac muscle cell action potential involved in contraction
GO:0086005 ventricular cardiac muscle cell action potential
GO:0086009 membrane repolarization
GO:0086011 membrane repolarization during action potential
GO:0086091 regulation of heart rate by cardiac conduction
GO:0097623 potassium ion export across plasma membrane
GO:0098915 membrane repolarization during ventricular cardiac muscle cell action potential
GO:1901379 regulation of potassium ion transmembrane transport
GO:1901387 positive regulation of voltage-gated calcium channel activity
GO:1901800 positive regulation of proteasomal protein catabolic process
GO:1901979 regulation of inward rectifier potassium channel activity
GO:1902159 regulation of cyclic nucleotide-gated ion channel activity
GO:1902259 regulation of delayed rectifier potassium channel activity
GO:1902260 negative regulation of delayed rectifier potassium channel activity
GO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
GO:1990573 potassium ion import across plasma membrane

Diseases

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Disease IDSourceNameDescription
611493 OMIMAtrial fibrillation, familial, 4 (ATFB4)A familial form of atrial fibrillation, a common sustained cardiac rhythm disturbance. Atrial fibrillation is characterized by disorganized atrial electrical activity and ineffective atrial contraction promoting blood stasis in the atria and reduces ventricular filling. It can result in palpitations, syncope, thromboembolic stroke, and congestive heart failure. The disease is caused by variants affecting the gene represented in this entry.
613693 OMIMLong QT syndrome 6 (LQT6)A heart disorder characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to exercise or emotional stress, and can present with a sentinel event of sudden cardiac death in infancy. The disease is caused by variants affecting the gene represented in this entry.

Interactions

4 interactions

InteractorPartnerSourcesPublicationsLink
KCNE2KCNQ1BioGRID, HPRD11101505 details
KCNE2CACNA1CBioGRID24681347 details
KCNE2ATP4ABioGRID17255364 details
KCNE2KCNH2HPRD11278781 details