Entity Details

Primary name COLI_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP01189
EntryNameCOLI_HUMAN
FullNamePro-opiomelanocortin
TaxID9606
Evidenceevidence at protein level
Length267
SequenceStatuscomplete
DateCreated1986-07-21
DateModified2021-06-02

Ontological Relatives

GenesPOMC

GO terms

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GOName
GO:0001664 G protein-coupled receptor binding
GO:0002862 negative regulation of inflammatory response to antigenic stimulus
GO:0005102 signaling receptor binding
GO:0005179 hormone activity
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005782 peroxisomal matrix
GO:0006091 generation of precursor metabolites and energy
GO:0007165 signal transduction
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007218 neuropeptide signaling pathway
GO:0007267 cell-cell signaling
GO:0008217 regulation of blood pressure
GO:0019221 cytokine-mediated signaling pathway
GO:0030141 secretory granule
GO:0031640 killing of cells of other organism
GO:0031781 type 3 melanocortin receptor binding
GO:0031782 type 4 melanocortin receptor binding
GO:0032098 regulation of appetite
GO:0032720 negative regulation of tumor necrosis factor production
GO:0033059 cellular pigmentation
GO:0034774 secretory granule lumen
GO:0035821 modulation of process of other organism
GO:0042593 glucose homeostasis
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide
GO:0070873 regulation of glycogen metabolic process
GO:0070965 positive regulation of neutrophil mediated killing of fungus
GO:0070996 type 1 melanocortin receptor binding
GO:2000852 regulation of corticosterone secretion

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR001941 Pro-opiomelanocortinFamilyFamily
IPR013531 Pro-opiomelanocortin/corticotropin, ACTH, central regionDomainDomain
IPR013532 Opiodes neuropeptideDomainDomain
IPR013593 Pro-opiomelanocortin N-terminalDomainDomain

Diseases

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Disease IDSourceNameDescription
609734 OMIMObesity, early-onset, with adrenal insufficiency and red hair (OBAIRH)An autosomal recessive disorder characterized by early-onset obesity due to severe hyperphagia, pigmentary abnormalities, mainly pale skin and red hair, and secondary hypocortisolism. The disease is caused by variants affecting the gene represented in this entry.
601665 OMIMObesity (OBESITY)A condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat. Disease susceptibility may be associated with variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB00836 LoperamideDrugbanksmall molecule
DB01497 EtorphineDrugbanksmall molecule
DB01565 DihydromorphineDrugbanksmall molecule

Interactions

28 interactions

InteractorPartnerSourcesPublicationsLink
COLI_HUMANHSF2B_HUMANBioGRID, IntAct32296183 details
COLI_HUMANGLCTK_HUMANBioGRID, IntAct32296183 details
COLI_HUMANVA0D2_HUMANBioGRID, IntAct32296183 details
COLI_HUMANKLH42_HUMANBioGRID, IntAct32296183 details
COLI_HUMANNTAQ1_HUMANBioGRID, IntAct32296183 details
COLI_HUMANABI2_HUMANBioGRID, IntAct32296183 details
COLI_HUMANBHA09_HUMANBioGRID, IntAct32296183 details
COLI_HUMANIKBD_HUMANBioGRID, IntAct32296183 details
COLI_HUMANCA109_HUMANBioGRID, IntAct32296183 details
COLI_HUMANC102B_HUMANBioGRID, IntAct32296183 details
COLI_HUMANTHIOM_HUMANBioGRID, IntAct32296183 details
COLI_HUMANSUOX_HUMANBioGRID, IntAct32296183 details
COLI_HUMANERR3_HUMANBioGRID, IntAct32296183 details
COLI_HUMANMKRN3_HUMANBioGRID, IntAct32296183 details
COLI_HUMANHDDC2_HUMANBioGRID, IntAct32296183 details
COLI_HUMANOAZ3_HUMANBioGRID, IntAct32296183 details
COLI_HUMANVTNC_HUMANBioGRID, HPRD2475499 details
COLI_HUMANMC4R_HUMANBioGRID, HPRD11101306 12165561 9058374 details
COLI_HUMANMC5R_HUMANBioGRID, HPRD11606131 8185570 9058374 details
COLI_HUMANMC3R_HUMANBioGRID9058374 details
COLI_HUMANMSHR_HUMANBioGRID, HPRD10942578 11041375 9058374 details
COLI_HUMANA4_HUMANBioGRID21832049 details
COLI_HUMANDRB3_HUMANBioGRID, HPRD7477400 details
COLI_HUMANMEP1A_HUMANHPRD11278902 details
COLI_HUMANACTHR_HUMANHPRD12213892 details
COLI_HUMANNRDC_HUMANHPRD12590613 details
COLI_HUMANFGF10_HUMANHPRD12591959 details
COLI_HUMANAMD_HUMANHPRD18052119 details