Entity Details
| Primary name |
IYD1_HUMAN |
| Entity type |
UniProt |
| Source |
Source Link |
Details
| Accession | Q6PHW0 |
| EntryName | IYD1_HUMAN |
| FullName | Iodotyrosine deiodinase 1 |
| TaxID | 9606 |
| Evidence | evidence at protein level |
| Length | 289 |
| SequenceStatus | complete |
| DateCreated | 2006-04-04 |
| DateModified | 2021-06-02 |
Subcellular Location
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| Subcellular Location |
| Cell membrane |
| Cytoplasmic vesicle membrane |
Domains
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| Domain | Name | Category | Type |
| IPR000415 | Nitroreductase-like | Family | Homologous superfamily |
| IPR029479 | Nitroreductase | Domain | Domain |
Diseases
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| Disease ID | Source | Name | Description |
| 274800 | OMIM | Thyroid dyshormonogenesis 4 (TDH4) | A disorder due to thyroid dyshormonogenesis, causing severe hypothyroidism, goiter, excessive levels of iodotyrosine in serum and urine, and variable mental deficits derived from unrecognized and untreated hypothyroidism. The disease is caused by variants affecting the gene represented in this entry. |
Drugs
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| Drug | Name | Source | Type |
| DB03374 | 3,5-Diiodotyrosine | Drugbank | small molecule |
Interactions
1 interaction