Entity Details

Primary name SIAH1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ8IUQ4
EntryNameSIAH1_HUMAN
FullNameE3 ubiquitin-protein ligase SIAH1
TaxID9606
Evidenceevidence at protein level
Length282
SequenceStatuscomplete
DateCreated2004-04-26
DateModified2021-06-02

Ontological Relatives

GenesSIAH1

GO terms

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GOName
GO:0000209 protein polyubiquitination
GO:0004842 ubiquitin-protein transferase activity
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005769 early endosome
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0006915 apoptotic process
GO:0007049 cell cycle
GO:0007283 spermatogenesis
GO:0007399 nervous system development
GO:0007411 axon guidance
GO:0008022 protein C-terminus binding
GO:0008270 zinc ion binding
GO:0009653 anatomical structure morphogenesis
GO:0030163 protein catabolic process
GO:0030877 beta-catenin destruction complex
GO:0031624 ubiquitin conjugating enzyme binding
GO:0031648 protein destabilization
GO:0042802 identical protein binding
GO:0043065 positive regulation of apoptotic process
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051402 neuron apoptotic process
GO:0061630 ubiquitin protein ligase activity
GO:1902842 negative regulation of netrin-activated signaling pathway
GO:1990000 amyloid fibril formation
GO:2001244 positive regulation of intrinsic apoptotic signaling pathway

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR001841 Zinc finger, RING-typeDomainDomain
IPR004162 E3 ubiquitin-protein ligase SINA-like, animalFamilyFamily
IPR008974 TRAF-likeFamilyHomologous superfamily
IPR013010 Zinc finger, SIAH-typeDomainDomain
IPR013083 Zinc finger, RING/FYVE/PHD-typeFamilyHomologous superfamily
IPR018121 Seven-in-absentia protein, TRAF-like domainDomainDomain

Diseases

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Interactions

196 interactions

InteractorPartnerSourcesPublicationsLink
SIAH1_HUMANCYBP_HUMANBioGRID, HPRD, IntAct, MINT11389839 12421809 16085652 20181957 22295074 23208506 25241761 29099417 details
SIAH1_HUMANNHRF2_HUMANHPRD, MINT12421809 details
SIAH1_HUMANHIPK3_HUMANBioGRID, HPRD, MINT15231748 details
SIAH1_HUMANKHDR3_HUMANBioGRID, HPRD, IntAct15163637 16189514 23208506 details
SIAH1_HUMANATN1_HUMANBioGRID, HPRD, IntAct16713569 21988832 details
SIAH1_HUMANUB2D2_HUMANBioGRID, IntAct18536714 19224863 19549727 19690564 details
SIAH1_HUMANUB2D3_HUMANBioGRID, IntAct17420721 19250734 19549727 19690564 22483617 details
SIAH1_HUMANUB2D4_HUMANBioGRID, IntAct19690564 details
SIAH1_HUMANUBE2K_HUMANBioGRID, IntAct19549727 25416956 32814053 details
SIAH1_HUMANUBE2N_HUMANBioGRID, IntAct19549727 details
SIAH1_HUMANUB2D1_HUMANBioGRID, HPRD, IntAct11389839 18070888 18298843 19549727 20181957 details
SIAH1_HUMANUB2V2_HUMANBioGRID, IntAct19549727 details
SIAH1_HUMANATX7_HUMANBioGRID, IntAct21078624 details
SIAH1_HUMANPHC2_HUMANBioGRID, IntAct, MINT20471960 21516116 21988832 25416956 details
SIAH1_HUMANPUF60_HUMANBioGRID, IntAct, MINT21516116 21988832 23208506 25416956 details
SIAH1_HUMANNUMB_HUMANBioGRID, HPRD, IntAct11752454 21988832 details
SIAH1_HUMANEF1D_HUMANBioGRID, IntAct21633900 21988832 25416956 details
SIAH1_HUMANMYD88_HUMANBioGRID, IntAct21988832 32117091 details
SIAH1_HUMANSIAH1_HUMANBioGRID, HPRD, IntAct11752454 12421809 12810624 17420721 19224863 20940148 21248071 21988832 22493164 23027902 24316825 25416956 32479599 9582267 details
SIAH1_HUMANSTAT3_HUMANBioGRID, IntAct21988832 27871173 details
SIAH1_HUMANTFDP1_HUMANBioGRID, IntAct21988832 details
SIAH1_HUMANASPP2_HUMANBioGRID, IntAct21988832 25416956 details
SIAH1_HUMANTHIO_HUMANBioGRID, IntAct21988832 details
SIAH1_HUMANNUMBL_HUMANBioGRID, IntAct21988832 details
SIAH1_HUMANACK1_HUMANBioGRID, IntAct21988832 23208506 details
SIAH1_HUMANRAPH1_HUMANBioGRID, IntAct21988832 details
SIAH1_HUMANTRIM8_HUMANBioGRID, IntAct22493164 details
SIAH1_HUMANAPC_HUMANBioGRID, HPRD, IntAct11389840 25241761 details
SIAH1_HUMANOPRM_HUMANBioGRID, IntAct23840749 details
SIAH1_HUMANOBF1_HUMANBioGRID, HPRD, IntAct11483517 11483518 details
SIAH1_HUMANPRP31_HUMANBioGRID, IntAct25416956 25910212 details
SIAH1_HUMANSDCB1_HUMANBioGRID, IntAct25416956 details
SIAH1_HUMANIDLC_HUMANBioGRID, IntAct25416956 details
SIAH1_HUMANSYT7_HUMANBioGRID, IntAct25416956 details
SIAH1_HUMANKIF1B_HUMANBioGRID, IntAct25416956 details
SIAH1_HUMANMABP1_HUMANBioGRID, IntAct25416956 details
SIAH1_HUMANUPP2_HUMANBioGRID, IntAct25416956 26871637 details
SIAH1_HUMANINHA_HUMANBioGRID, IntAct25416956 25910212 details
SIAH1_HUMANPFKAM_HUMANBioGRID, IntAct25416956 details
SIAH1_HUMANPYGB_HUMANBioGRID, IntAct25416956 details
SIAH1_HUMANMX1_HUMANBioGRID, IntAct25416956 details
SIAH1_HUMANAQP1_HUMANBioGRID, IntAct25416956 details
SIAH1_HUMANTRI23_HUMANBioGRID, IntAct25416956 details
SIAH1_HUMANCAPG_HUMANBioGRID, IntAct25416956 details
SIAH1_HUMANBCL6_HUMANBioGRID, IntAct25416956 details
SIAH1_HUMANUB2R1_HUMANBioGRID, IntAct25416956 details
SIAH1_HUMANMK12_HUMANBioGRID, IntAct25416956 details
SIAH1_HUMANH4_HUMANBioGRID, IntAct25416956 details
SIAH1_HUMANKCJ10_HUMANBioGRID, IntAct25416956 details
SIAH1_HUMANPR20C_HUMANBioGRID, IntAct25416956 28514442 32296183 details
SIAH1_HUMANFLI1_HUMANBioGRID, IntAct25416956 details
SIAH1_HUMANMB211_HUMANBioGRID, IntAct25416956 details
SIAH1_HUMANRB33A_HUMANBioGRID, IntAct25416956 details
SIAH1_HUMANCC198_HUMANBioGRID, IntAct25416956 details
SIAH1_HUMANQRIC1_HUMANBioGRID, IntAct25416956 details
SIAH1_HUMANLACB2_HUMANBioGRID, IntAct25416956 details
SIAH1_HUMANSKT_HUMANBioGRID, IntAct25416956 details
SIAH1_HUMANMOB3C_HUMANBioGRID, IntAct25416956 details
SIAH1_HUMANARMC9_HUMANBioGRID, IntAct25416956 details
SIAH1_HUMANPEG10_HUMANBioGRID, HPRD, IntAct12810624 25416956 details
SIAH1_HUMANAROS_HUMANBioGRID, IntAct25416956 details
SIAH1_HUMANF90A1_HUMANBioGRID, IntAct25416956 details
SIAH1_HUMANTRI27_HUMANBioGRID, IntAct25416956 details
SIAH1_HUMANKIFC3_HUMANBioGRID, IntAct25416956 details
SIAH1_HUMANAFF4_HUMANBioGRID, HPRD, IntAct16189514 25416956 details
SIAH1_HUMANK319L_HUMANBioGRID, IntAct25416956 details
SIAH1_HUMANEXAS1_HUMANIntAct25416956 details
SIAH1_HUMANSPAT4_HUMANBioGRID, IntAct25416956 details
SIAH1_HUMANZCH10_HUMANBioGRID, IntAct25416956 details
SIAH1_HUMANGDPD5_HUMANBioGRID, IntAct25416956 details
SIAH1_HUMANPTPM1_HUMANBioGRID, IntAct25416956 details
SIAH1_HUMANZCH13_HUMANBioGRID, IntAct25416956 details
SIAH1_HUMANNECT2_HUMANBioGRID, IntAct25416956 details
SIAH1_HUMANR51A1_HUMANBioGRID, IntAct25416956 32296183 details
SIAH1_HUMANOTUB2_HUMANBioGRID, IntAct25416956 details
SIAH1_HUMANNTAQ1_HUMANBioGRID, IntAct25416956 details
SIAH1_HUMANZ512B_HUMANBioGRID, IntAct25416956 details
SIAH1_HUMANZFY21_HUMANBioGRID, IntAct25416956 details
SIAH1_HUMANTMM43_HUMANBioGRID, IntAct25416956 25910212 details
SIAH1_HUMANKATL1_HUMANBioGRID, IntAct25416956 details
SIAH1_HUMANTRIM7_HUMANBioGRID, IntAct25416956 details
SIAH1_HUMANSPC1L_HUMANBioGRID, IntAct25416956 details
SIAH1_HUMANIQCN_HUMANBioGRID, IntAct25416956 details
SIAH1_HUMANIF3M_HUMANBioGRID, IntAct25416956 details
SIAH1_HUMANNELFA_HUMANBioGRID, IntAct25416956 details
SIAH1_HUMANNOL6_HUMANBioGRID, IntAct25416956 details
SIAH1_HUMANZMAT3_HUMANBioGRID, IntAct25416956 details
SIAH1_HUMANADPPT_HUMANBioGRID, IntAct25416956 details
SIAH1_HUMANTB22B_HUMANBioGRID, IntAct25416956 details
SIAH1_HUMANUXT_HUMANBioGRID, IntAct25416956 details
SIAH1_HUMANDDX41_HUMANBioGRID, IntAct25416956 details
SIAH1_HUMANCDC23_HUMANBioGRID, IntAct25416956 details
SIAH1_HUMANZN148_HUMANBioGRID, IntAct25416956 details
SIAH1_HUMANARIP4_HUMANBioGRID, IntAct25416956 details
SIAH1_HUMANDJC15_HUMANBioGRID, IntAct25416956 details
SIAH1_HUMANPIMRE_HUMANBioGRID, IntAct26871637 details
SIAH1_HUMANRXRB_HUMANBioGRID, IntAct26871637 details
SIAH1_HUMANPAR6B_HUMANBioGRID, IntAct27107012 details
SIAH1_HUMANPR20D_HUMANBioGRID, IntAct25416956 28514442 32296183 details
SIAH1_HUMANBAG4_HUMANBioGRID, IntAct32296183 details
SIAH1_HUMANM1AP_HUMANBioGRID, IntAct32296183 details
SIAH1_HUMANMARE3_HUMANBioGRID, IntAct19696028 32296183 details
SIAH1_HUMANLANC2_HUMANBioGRID, IntAct32296183 details
SIAH1_HUMANRB33B_HUMANBioGRID, IntAct32296183 details
SIAH1_HUMANSMBT2_HUMANBioGRID, IntAct32296183 details
SIAH1_HUMANBAG3_HUMANBioGRID, IntAct32296183 details
SIAH1_HUMANPR20E_HUMANBioGRID, IntAct25416956 28514442 32296183 details
SIAH1_HUMANSIAH2_HUMANBioGRID, IntAct16899216 26186194 28514442 details
SIAH1_HUMANDCC_HUMANBioGRID, HPRD, IntAct31413325 9858595 details
SIAH1_HUMANAPLP2_HUMANIntAct32814053 details
SIAH1_HUMANA4_HUMANIntAct32814053 details
SIAH1_HUMANKC1D_HUMANIntAct32814053 details
SIAH1_HUMANKLK6_HUMANIntAct32814053 details
SIAH1_HUMANNCOR1_HUMANIntAct32814053 details
SIAH1_HUMANCOQA1_HUMANIntAct32814053 details
SIAH1_HUMANATX1_HUMANIntAct32814053 details
SIAH1_HUMANTADBP_HUMANIntAct32814053 details
SIAH1_HUMANKIF22_HUMANBioGRID, HPRD11146551 details
SIAH1_HUMANCTIP_HUMANBioGRID, HPRD14654780 26387952 details
SIAH1_HUMANDAB1_HUMANBioGRID, HPRD12646221 details
SIAH1_HUMANPEG3_HUMANBioGRID, HPRD10681424 details
SIAH1_HUMANUB2E3_HUMANBioGRID11389839 details
SIAH1_HUMANVAV_HUMANBioGRID10207103 details
SIAH1_HUMANBAG1_HUMANBioGRID, HPRD12421809 9582267 details
SIAH1_HUMANHIF1N_HUMANBioGRID18280659 details
SIAH1_HUMANTRIB3_HUMANBioGRID18276110 details
SIAH1_HUMANPIAS1_HUMANBioGRID17533377 27485016 details
SIAH1_HUMANPIAS2_HUMANBioGRID17533377 details
SIAH1_HUMANUBC9_HUMANBioGRID17533377 9334332 details
SIAH1_HUMANPIAS3_HUMANBioGRID17533377 details
SIAH1_HUMANPKD1_HUMANBioGRID, HPRD15284290 details
SIAH1_HUMANSNCAP_HUMANBioGRID, HPRD14506261 15064394 details
SIAH1_HUMANUB2L6_HUMANBioGRID18073335 details
SIAH1_HUMANUB2E2_HUMANBioGRID18065497 18073335 details
SIAH1_HUMANHIPK2_HUMANBioGRID18536714 19043406 19250734 23503458 details
SIAH1_HUMANCTNB1_HUMANBioGRID20181957 24882689 27871173 28481365 32671611 details
SIAH1_HUMANSYUA_HUMANBioGRID18065497 18070888 19224863 27334109 details
SIAH1_HUMANTERF2_HUMANBioGRID21057505 details
SIAH1_HUMANFLT3_HUMANBioGRID20508617 details
SIAH1_HUMANELL2_HUMANBioGRID22483617 32479599 details
SIAH1_HUMANUBP19_HUMANBioGRID22128162 23500468 27776223 details
SIAH1_HUMANAFF1_HUMANBioGRID, HPRD15221006 details
SIAH1_HUMANSH3R1_HUMANBioGRID, HPRD16230351 details
SIAH1_HUMANKLF10_HUMANBioGRID12072443 25728284 details
SIAH1_HUMANG3P_HUMANBioGRID, HPRD15951807 22534308 23027902 25391652 26438826 details
SIAH1_HUMANGRM5_HUMANBioGRID23152621 details
SIAH1_HUMANPHC1_HUMANBioGRID25416956 details
SIAH1_HUMANRL27A_HUMANBioGRID25416956 details
SIAH1_HUMANFZD9_HUMANBioGRID25416956 details
SIAH1_HUMANCD5R1_HUMANBioGRID25416956 details
SIAH1_HUMANTOLIP_HUMANBioGRID25416956 details
SIAH1_HUMANZN671_HUMANBioGRID25416956 details
SIAH1_HUMANZBP1_HUMANBioGRID25416956 details
SIAH1_HUMANPR20B_HUMANBioGRID25416956 28514442 32296183 details
SIAH1_HUMANPR20A_HUMANBioGRID25416956 28514442 32296183 details
SIAH1_HUMANSYPH_HUMANBioGRID, HPRD11786535 25755825 details
SIAH1_HUMANM3K5_HUMANBioGRID25391652 details
SIAH1_HUMANLMNA_HUMANBioGRID24623722 details
SIAH1_HUMANAXIN1_HUMANBioGRID26871637 28546513 details
SIAH1_HUMANZYX_HUMANBioGRID21248071 details
SIAH1_HUMANAIMP2_HUMANBioGRID31792442 32315177 details
SIAH1_HUMANHCFC1_HUMANBioGRID32479599 details
SIAH1_HUMANHCFC2_HUMANBioGRID32479599 details
SIAH1_HUMANTBA4A_HUMANHPRD11146551 details
SIAH1_HUMANTBA3C_HUMANHPRD11146551 details
SIAH1_HUMANTBA3D_HUMANHPRD11146551 details
SIAH1_HUMANTBA1A_HUMANHPRD11146551 details
SIAH1_HUMANTBA1B_HUMANHPRD11146551 details
SIAH1_HUMANTBA8_HUMANHPRD11146551 details
SIAH1_HUMANXIAP_HUMANBioGRID, IntAct21185211 details
SIAH1_HUMANSEPT4_HUMANBioGRID, IntAct21185211 details
SIAH1_HUMANOPRK_HUMANBioGRID, IntAct23840749 details
SIAH1_HUMANP73_HUMANDIP25774835 details
SIAH1_HUMANDISC1_HUMANIntAct31413325 details
SIAH1_HUMANTBL1X_HUMANBioGRID11389839 details
SIAH1_HUMANRUNX1_HUMANBioGRID18073335 details
SIAH1_HUMANRNF12_HUMANBioGRID18073335 details
SIAH1_HUMANPML_HUMANBioGRID18073335 details
SIAH1_HUMANRARA_HUMANBioGRID18073335 details
SIAH1_HUMANPLCE1_HUMANBioGRID17998205 details
SIAH1_HUMANHERP1_HUMANBioGRID20604806 details
SIAH1_HUMANPRS8_HUMANBioGRID20479273 details
SIAH1_HUMANPRS10_HUMANBioGRID20479273 details
SIAH1_HUMANPARD3_HUMANBioGRID21109632 details
SIAH1_HUMANHD_HUMANBioGRID16492755 details
SIAH1_HUMANHIPK1_HUMANBioGRID19250734 details
SIAH1_HUMANRING2_HUMANBioGRID22493164 details
SIAH1_HUMANNPM_HUMANBioGRID23027902 details
SIAH1_HUMANCSN5_HUMANBioGRID24882689 details
SIAH1_HUMANOPRD_HUMANBioGRID23840749 details
SIAH1_HUMANLATS2_HUMANBioGRID25587023 details
SIAH1_HUMANAXIN2_HUMANBioGRID28546513 details
SIAH1_HUMANCDN1B_HUMANBioGRID29024247 details
SIAH1_HUMANTNR16_HUMANBioGRID30081046 details
SIAH1_HUMANTRAF4_HUMANBioGRID32671611 details
SIAH1_HUMANEIF3J_HUMANHPRD9822659 details