Entity Details

Primary name SIR6_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ8N6T7
EntryNameSIR6_HUMAN
FullNameNAD-dependent protein deacetylase sirtuin-6
TaxID9606
Evidenceevidence at protein level
Length355
SequenceStatuscomplete
DateCreated2003-10-31
DateModified2021-06-02

Ontological Relatives

GenesSIRT6

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0003247 post-embryonic cardiac muscle cell growth involved in heart morphogenesis
GO:0003714 transcription corepressor activity
GO:0003950 NAD+ ADP-ribosyltransferase activity
GO:0003956 NAD(P)+-protein-arginine ADP-ribosyltransferase activity
GO:0004407 histone deacetylase activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0006471 protein ADP-ribosylation
GO:0006476 protein deacetylation
GO:0008270 zinc ion binding
GO:0010569 regulation of double-strand break repair via homologous recombination
GO:0017136 NAD-dependent histone deacetylase activity
GO:0019213 deacetylase activity
GO:0031667 response to nutrient levels
GO:0031940 positive regulation of chromatin silencing at telomere
GO:0032206 positive regulation of telomere maintenance
GO:0046969 NAD-dependent histone deacetylase activity (H3-K9 specific)
GO:0070403 NAD+ binding
GO:0070932 histone H3 deacetylation
GO:0099115 chromosome, subtelomeric region
GO:0120162 positive regulation of cold-induced thermogenesis
GO:1901485 positive regulation of transcription factor catabolic process
GO:1902732 positive regulation of chondrocyte proliferation
GO:1905549 positive regulation of subtelomeric heterochromatin assembly
GO:1905555 positive regulation of blood vessel branching
GO:1905564 positive regulation of vascular endothelial cell proliferation

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR003000 Sirtuin familyFamilyFamily
IPR026590 Sirtuin family, catalytic core domainDomainDomain
IPR029035 DHS-like NAD/FAD-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

124 interactions

InteractorPartnerSourcesPublicationsLink
SIR6_HUMANCHD3_HUMANBioGRID, HPRD, IntAct, MINT16169070 21900206 details
SIR6_HUMANVIME_HUMANBioGRID, HPRD, IntAct, MINT16169070 21900206 details
SIR6_HUMANELF5_HUMANBioGRID, HPRD, IntAct16189514 details
SIR6_HUMANTF65_HUMANBioGRID, IntAct19135889 23240041 details
SIR6_HUMANFAF1_HUMANBioGRID, MINT21900206 details
SIR6_HUMANUB2D1_HUMANBioGRID, MINT21900206 details
SIR6_HUMANCHIP_HUMANBioGRID, IntAct24043303 25036637 details
SIR6_HUMANCCDB1_HUMANBioGRID17131381 details
SIR6_HUMANSKP2_HUMANBioGRID22770219 details
SIR6_HUMANAKT1_HUMANBioGRID25074979 details
SIR6_HUMANCHD4_HUMANBioGRID24169447 31970415 details
SIR6_HUMANUBP10_HUMANBioGRID24169447 29698567 details
SIR6_HUMANCDN1B_HUMANBioGRID27794562 details
SIR6_HUMANPIAS1_HUMANBioGRID23240041 details
SIR6_HUMANTDG_HUMANBioGRID23240041 details
SIR6_HUMANTSYL2_HUMANBioGRID23240041 details
SIR6_HUMANUBE3A_HUMANBioGRID29217762 details
SIR6_HUMANMUTYH_HUMANBioGRID26063178 details
SIR6_HUMANRAD9A_HUMANBioGRID26063178 details
SIR6_HUMANHUS1_HUMANBioGRID26063178 details
SIR6_HUMANRAD1_HUMANBioGRID26063178 details
SIR6_HUMANDDB2_HUMANBioGRID32789493 details
SIR6_HUMANMYC_HUMANIntAct23217706 details
SIR6_HUMANMLF1_HUMANIntAct25036637 details
SIR6_HUMANMLF2_HUMANIntAct25036637 details
SIR6_HUMANHSF2_HUMANIntAct25036637 details
SIR6_HUMANPSMD2_HUMANBioGRID, IntAct25036637 31842909 details
SIR6_HUMANFKBPL_HUMANIntAct25036637 details
SIR6_HUMANPTG3L_HUMANIntAct25036637 details
SIR6_HUMANAASD1_HUMANIntAct25036637 details
SIR6_HUMANMDM2_HUMANBioGRID, IntAct25074979 28196907 28514442 details
SIR6_HUMANCENPA_HUMANDIP27043296 details
SIR6_HUMANPRKDC_HUMANBioGRID20157594 24169447 details
SIR6_HUMANXRCC5_HUMANBioGRID20157594 details
SIR6_HUMANXRCC6_HUMANBioGRID20157594 details
SIR6_HUMANNR0B2_HUMANBioGRID20375098 details
SIR6_HUMANG3BP1_HUMANBioGRID24169447 details
SIR6_HUMANWDHD1_HUMANBioGRID24169447 details
SIR6_HUMANWAPL_HUMANBioGRID24169447 details
SIR6_HUMANWAC_HUMANBioGRID24169447 details
SIR6_HUMANUBP7_HUMANBioGRID24169447 details
SIR6_HUMANUBP48_HUMANBioGRID24169447 details
SIR6_HUMANUBR5_HUMANBioGRID24169447 details
SIR6_HUMANTXLNA_HUMANBioGRID24169447 details
SIR6_HUMANTBB2A_HUMANBioGRID24169447 details
SIR6_HUMANTBA1A_HUMANBioGRID24169447 details
SIR6_HUMANTIF1B_HUMANBioGRID24169447 details
SIR6_HUMANTRI25_HUMANBioGRID24169447 details
SIR6_HUMANTCPA_HUMANBioGRID24169447 details
SIR6_HUMANTCOF_HUMANBioGRID24169447 details
SIR6_HUMANTBL1R_HUMANBioGRID24169447 details
SIR6_HUMANHNRPQ_HUMANBioGRID24169447 details
SIR6_HUMANSPT5H_HUMANBioGRID24169447 details
SIR6_HUMANU520_HUMANBioGRID24169447 details
SIR6_HUMANSMC4_HUMANBioGRID24169447 details
SIR6_HUMANSMC3_HUMANBioGRID24169447 details
SIR6_HUMANSMC2_HUMANBioGRID24169447 details
SIR6_HUMANSMC1A_HUMANBioGRID24169447 details
SIR6_HUMANSART3_HUMANBioGRID24169447 details
SIR6_HUMANS10A9_HUMANBioGRID24169447 details
SIR6_HUMANS10A8_HUMANBioGRID24169447 details
SIR6_HUMANRUVB2_HUMANBioGRID24169447 details
SIR6_HUMANRUVB1_HUMANBioGRID24169447 details
SIR6_HUMANBRE1B_HUMANBioGRID24169447 details
SIR6_HUMANBRE1A_HUMANBioGRID24169447 details
SIR6_HUMANRBBP7_HUMANBioGRID24169447 details
SIR6_HUMANRBBP4_HUMANBioGRID24169447 details
SIR6_HUMANRAD50_HUMANBioGRID24169447 details
SIR6_HUMANRAD21_HUMANBioGRID24169447 details
SIR6_HUMANPRS10_HUMANBioGRID24169447 details
SIR6_HUMANPRP8_HUMANBioGRID24169447 details
SIR6_HUMANANM5_HUMANBioGRID24169447 details
SIR6_HUMANDPOD3_HUMANBioGRID24169447 details
SIR6_HUMANDPOD2_HUMANBioGRID24169447 details
SIR6_HUMANPDS5A_HUMANBioGRID24169447 details
SIR6_HUMANPDLI5_HUMANBioGRID24169447 details
SIR6_HUMANPALLD_HUMANBioGRID24169447 details
SIR6_HUMANNPM_HUMANBioGRID24169447 details
SIR6_HUMANCND1_HUMANBioGRID24169447 details
SIR6_HUMANMTA2_HUMANBioGRID24169447 details
SIR6_HUMANMSH6_HUMANBioGRID24169447 details
SIR6_HUMANMSH2_HUMANBioGRID24169447 details
SIR6_HUMANMATR3_HUMANBioGRID24169447 details
SIR6_HUMANLMNA_HUMANBioGRID24169447 30419336 details
SIR6_HUMANLARP7_HUMANBioGRID24169447 details
SIR6_HUMANK2C3_HUMANBioGRID24169447 details
SIR6_HUMANKIF4A_HUMANBioGRID24169447 details
SIR6_HUMANCCAR2_HUMANBioGRID24169447 details
SIR6_HUMANIMDH2_HUMANBioGRID24169447 details
SIR6_HUMANHSP7C_HUMANBioGRID24169447 details
SIR6_HUMANHSP72_HUMANBioGRID24169447 details
SIR6_HUMANHS71L_HUMANBioGRID24169447 details
SIR6_HUMANHNRPK_HUMANBioGRID24169447 details
SIR6_HUMANHNRH1_HUMANBioGRID24169447 details
SIR6_HUMANHDAC2_HUMANBioGRID24169447 details
SIR6_HUMANHDAC1_HUMANBioGRID24169447 details
SIR6_HUMANGTF2I_HUMANBioGRID24169447 details
SIR6_HUMANP66B_HUMANBioGRID24169447 details
SIR6_HUMANG3P_HUMANBioGRID24169447 details
SIR6_HUMANFLNB_HUMANBioGRID24169447 details
SIR6_HUMANFLNA_HUMANBioGRID24169447 details
SIR6_HUMANU5S1_HUMANBioGRID24169447 details
SIR6_HUMANEF2_HUMANBioGRID24169447 details
SIR6_HUMANEF1G_HUMANBioGRID24169447 details
SIR6_HUMANEF1A1_HUMANBioGRID24169447 details
SIR6_HUMANDDB1_HUMANBioGRID24169447 details
SIR6_HUMANCOR1B_HUMANBioGRID24169447 details
SIR6_HUMANCDC27_HUMANBioGRID24169447 details
SIR6_HUMANTCPQ_HUMANBioGRID24169447 details
SIR6_HUMANTCPE_HUMANBioGRID24169447 details
SIR6_HUMANCAPZB_HUMANBioGRID24169447 details
SIR6_HUMANCAZA1_HUMANBioGRID24169447 details
SIR6_HUMANCAPR1_HUMANBioGRID24169447 details
SIR6_HUMANANXA2_HUMANBioGRID24169447 details
SIR6_HUMANAPC7_HUMANBioGRID24169447 details
SIR6_HUMANAPC1_HUMANBioGRID24169447 details
SIR6_HUMANACTN1_HUMANBioGRID24169447 details
SIR6_HUMANACLY_HUMANBioGRID24169447 details
SIR6_HUMANDESP_HUMANBioGRID24169447 details
SIR6_HUMANMBB1A_HUMANBioGRID23240041 details
SIR6_HUMANSMCA5_HUMANBioGRID23240041 details
SIR6_HUMANAPEX1_HUMANBioGRID26063178 details
SIR6_HUMANFOXO3_HUMANBioGRID30542728 details
SIR6_HUMANNQO1_HUMANBioGRID31842909 details