Entity Details

Primary name GFRA2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO00451
EntryNameGFRA2_HUMAN
FullNameGDNF family receptor alpha-2
TaxID9606
Evidenceevidence at protein level
Length464
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesGFRA2

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0005886 plasma membrane
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007399 nervous system development
GO:0007411 axon guidance
GO:0009897 external side of plasma membrane
GO:0016167 glial cell-derived neurotrophic factor receptor activity
GO:0019898 extrinsic component of membrane
GO:0031225 anchored component of membrane
GO:0031953 negative regulation of protein autophosphorylation
GO:0038023 signaling receptor activity
GO:0043235 receptor complex

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR003438 Glial cell line-derived neurotrophic factor receptorFamilyFamily
IPR003504 Glial cell line-derived neurotrophic factor receptor alpha 2FamilyFamily
IPR016017 GDNF/GAS1DomainDomain
IPR017372 Glial cell line-derived neurotrophic factor receptor, alpha 1/2FamilyFamily
IPR037193 GDNF receptor alphaFamilyHomologous superfamily

Diseases

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Interactions

3 interactions

InteractorPartnerSourcesPublicationsLink
GFRA2_HUMANNRTN_HUMANBioGRID, HPRD10829012 9407096 details
GFRA2_HUMANGDNF_HUMANBioGRID, HPRD10829012 9407096 details
GFRA2_HUMANPTEN_HUMANBioGRID15717329 details