Entity Details

Primary name LIRB1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ8NHL6
EntryNameLIRB1_HUMAN
FullNameLeukocyte immunoglobulin-like receptor subfamily B member 1
TaxID9606
Evidenceevidence at protein level
Length650
SequenceStatuscomplete
DateCreated2003-10-03
DateModified2021-06-02

Ontological Relatives

GenesLILRB1

GO terms

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GOName
GO:0001915 negative regulation of T cell mediated cytotoxicity
GO:0002230 positive regulation of defense response to virus by host
GO:0002250 adaptive immune response
GO:0002309 T cell proliferation involved in immune response
GO:0002719 negative regulation of cytokine production involved in immune response
GO:0002767 immune response-inhibiting cell surface receptor signaling pathway
GO:0002774 Fc receptor mediated inhibitory signaling pathway
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0007165 signal transduction
GO:0008157 protein phosphatase 1 binding
GO:0009615 response to virus
GO:0009897 external side of plasma membrane
GO:0010628 positive regulation of gene expression
GO:0014063 negative regulation of serotonin secretion
GO:0016021 integral component of membrane
GO:0023025 MHC class Ib protein complex binding
GO:0023029 MHC class Ib protein binding
GO:0030107 HLA-A specific inhibitory MHC class I receptor activity
GO:0030109 HLA-B specific inhibitory MHC class I receptor activity
GO:0031623 receptor internalization
GO:0032393 MHC class I receptor activity
GO:0032394 MHC class Ib receptor activity
GO:0032688 negative regulation of interferon-beta production
GO:0032689 negative regulation of interferon-gamma production
GO:0032693 negative regulation of interleukin-10 production
GO:0032695 negative regulation of interleukin-12 production
GO:0032720 negative regulation of tumor necrosis factor production
GO:0032729 positive regulation of interferon-gamma production
GO:0032945 negative regulation of mononuclear cell proliferation
GO:0042130 negative regulation of T cell proliferation
GO:0042169 SH2 domain binding
GO:0042288 MHC class I protein binding
GO:0042803 protein homodimerization activity
GO:0043065 positive regulation of apoptotic process
GO:0045786 negative regulation of cell cycle
GO:0045806 negative regulation of endocytosis
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0045953 negative regulation of natural killer cell mediated cytotoxicity
GO:0046636 negative regulation of alpha-beta T cell activation
GO:0050776 regulation of immune response
GO:0051607 defense response to virus
GO:0051926 negative regulation of calcium ion transport
GO:0060907 positive regulation of macrophage cytokine production
GO:0071222 cellular response to lipopolysaccharide
GO:0071635 negative regulation of transforming growth factor beta production
GO:0097028 dendritic cell differentiation
GO:2000669 negative regulation of dendritic cell apoptotic process
GO:2001186 negative regulation of CD8-positive, alpha-beta T cell activation
GO:2001189 negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
GO:2001193 positive regulation of gamma-delta T cell activation involved in immune response
GO:2001199 negative regulation of dendritic cell differentiation
GO:2001205 negative regulation of osteoclast development

Subcellular Location

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Subcellular Location
Cell membrane
Secreted

Domains

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DomainNameCategoryType
IPR003598 Immunoglobulin subtype 2DomainDomain
IPR003599 Immunoglobulin subtypeDomainDomain
IPR007110 Immunoglobulin-like domainDomainDomain
IPR013151 ImmunoglobulinDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR036179 Immunoglobulin-like domain superfamilyFamilyHomologous superfamily

Diseases

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