Entity Details

Primary name DTX3L_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ8TDB6
EntryNameDTX3L_HUMAN
FullNameE3 ubiquitin-protein ligase DTX3L
TaxID9606
Evidenceevidence at protein level
Length740
SequenceStatuscomplete
DateCreated2003-09-26
DateModified2021-06-02

Ontological Relatives

GenesDTX3L

GO terms

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GOName
GO:0000209 protein polyubiquitination
GO:0002230 positive regulation of defense response to virus by host
GO:0004842 ubiquitin-protein transferase activity
GO:0004857 enzyme inhibitor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005764 lysosome
GO:0005765 lysosomal membrane
GO:0005829 cytosol
GO:0006302 double-strand break repair
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0006974 cellular response to DNA damage stimulus
GO:0007219 Notch signaling pathway
GO:0008047 enzyme activator activity
GO:0008333 endosome to lysosome transport
GO:0010390 histone monoubiquitination
GO:0015031 protein transport
GO:0016032 viral process
GO:0016567 protein ubiquitination
GO:0019899 enzyme binding
GO:0031901 early endosome membrane
GO:0032092 positive regulation of protein binding
GO:0032991 protein-containing complex
GO:0033522 histone H2A ubiquitination
GO:0033523 histone H2B ubiquitination
GO:0035563 positive regulation of chromatin binding
GO:0042393 histone binding
GO:0044389 ubiquitin-like protein ligase binding
GO:0045087 innate immune response
GO:0045893 positive regulation of transcription, DNA-templated
GO:0046872 metal ion binding
GO:0051444 negative regulation of ubiquitin-protein transferase activity
GO:0051607 defense response to virus
GO:0051865 protein autoubiquitination
GO:0061630 ubiquitin protein ligase activity
GO:0070936 protein K48-linked ubiquitination
GO:0097677 STAT family protein binding
GO:1900182 positive regulation of protein localization to nucleus
GO:1901666 positive regulation of NAD+ ADP-ribosyltransferase activity
GO:1902966 positive regulation of protein localization to early endosome
GO:2000646 positive regulation of receptor catabolic process
GO:2001034 positive regulation of double-strand break repair via nonhomologous end joining

Subcellular Location

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Subcellular Location
Cytoplasm
Early endosome membrane
Lysosome membrane
Nucleus

Domains

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DomainNameCategoryType
IPR001841 Zinc finger, RING-typeDomainDomain
IPR012677 Nucleotide-binding alpha-beta plait domain superfamilyFamilyHomologous superfamily
IPR013083 Zinc finger, RING/FYVE/PHD-typeFamilyHomologous superfamily
IPR017907 Zinc finger, RING-type, conserved siteSiteConserved site
IPR039396 Deltex, C-terminalDomainDomain
IPR039398 Deltex familyFamilyFamily
IPR039399 Deltex, C-terminal domain superfamilyFamilyHomologous superfamily
IPR042843 DTX3L, RING-HC fingerDomainDomain

Diseases

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Interactions

33 interactions

InteractorPartnerSourcesPublicationsLink
DTX3L_HUMANUB2D1_HUMANBioGRID, HPRD, IntAct12670957 19549727 19818714 details
DTX3L_HUMANUB2D2_HUMANBioGRID, HPRD, IntAct12670957 19549727 19818714 details
DTX3L_HUMANUB2D3_HUMANBioGRID, HPRD, IntAct12670957 19549727 details
DTX3L_HUMANUB2E1_HUMANBioGRID, IntAct19549727 details
DTX3L_HUMANUB2E2_HUMANBioGRID, IntAct19549727 details
DTX3L_HUMANUB2E3_HUMANBioGRID, IntAct19549727 details
DTX3L_HUMANUB2D4_HUMANBioGRID, IntAct19549727 details
DTX3L_HUMANUBE2W_HUMANBioGRID, IntAct19549727 details
DTX3L_HUMANUBE2H_HUMANBioGRID, IntAct19549727 details
DTX3L_HUMANUBC9_HUMANBioGRID, IntAct19549727 details
DTX3L_HUMANUB2R2_HUMANBioGRID, IntAct19549727 details
DTX3L_HUMANRN111_HUMANBioGRID, IntAct22493164 details
DTX3L_HUMANPHF7_HUMANBioGRID, IntAct22493164 details
DTX3L_HUMANTRIM9_HUMANBioGRID, IntAct22493164 details
DTX3L_HUMANSPG21_HUMANBioGRID, IntAct25416956 32296183 details
DTX3L_HUMANPARP9_HUMANBioGRID, HPRD, IntAct12670957 24886089 26479788 28514442 32937373 32948590 details
DTX3L_HUMANUBE2K_HUMANBioGRID, IntAct19549727 32814053 details
DTX3L_HUMANDTX3L_HUMANBioGRID, HPRD12670957 24790097 details
DTX3L_HUMANH4_HUMANBioGRID19818714 details
DTX3L_HUMANITCH_HUMANBioGRID24790097 details
DTX3L_HUMANH2B1J_HUMANBioGRID26479788 details
DTX3L_HUMANH2AV_HUMANBioGRID26479788 details
DTX3L_HUMANUCRIL_HUMANIntAct30021884 details
DTX3L_HUMANDTX1_HUMANBioGRID, HPRD12670957 details
DTX3L_HUMANHGS_HUMANBioGRID24790097 details
DTX3L_HUMANSTAM1_HUMANBioGRID24790097 details
DTX3L_HUMANPAR14_HUMANBioGRID24886089 details
DTX3L_HUMANINGR1_HUMANBioGRID24886089 details
DTX3L_HUMANJAK1_HUMANBioGRID24886089 details
DTX3L_HUMANJAK2_HUMANBioGRID24886089 details
DTX3L_HUMANSTAT1_HUMANBioGRID24886089 26479788 details
DTX3L_HUMANPARP1_HUMANBioGRID23230272 details
DTX3L_HUMANNOTC2_HUMANBioGRID31854042 details