Entity Details

Primary name PTPRT_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO14522
EntryNamePTPRT_HUMAN
FullNameReceptor-type tyrosine-protein phosphatase T
TaxID9606
Evidenceevidence at protein level
Length1441
SequenceStatuscomplete
DateCreated2003-07-19
DateModified2021-06-02

Ontological Relatives

GenesPTPRT

GO terms

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GOName
GO:0004725 protein tyrosine phosphatase activity
GO:0005001 transmembrane receptor protein tyrosine phosphatase activity
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006470 protein dephosphorylation
GO:0007155 cell adhesion
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules
GO:0007165 signal transduction
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0008013 beta-catenin binding
GO:0009986 cell surface
GO:0016021 integral component of membrane
GO:0016790 thiolester hydrolase activity
GO:0019903 protein phosphatase binding
GO:0030336 negative regulation of cell migration
GO:0035335 peptidyl-tyrosine dephosphorylation
GO:0042803 protein homodimerization activity
GO:0045294 alpha-catenin binding
GO:0045295 gamma-catenin binding
GO:0045296 cadherin binding
GO:0050807 regulation of synapse organization
GO:0051393 alpha-actinin binding
GO:0070097 delta-catenin binding
GO:0071354 cellular response to interleukin-6
GO:0097677 STAT family protein binding
GO:0098978 glutamatergic synapse
GO:0099061 integral component of postsynaptic density membrane
GO:1904893 negative regulation of receptor signaling pathway via STAT
GO:1990264 peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity

Subcellular Location

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Subcellular Location
Membrane

Domains

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DomainNameCategoryType
IPR000242 PTP type protein phosphataseDomainDomain
IPR000387 Tyrosine specific protein phosphatases domainDomainDomain
IPR000998 MAM domainDomainDomain
IPR003595 Protein-tyrosine phosphatase, catalyticDomainDomain
IPR003961 Fibronectin type IIIDomainDomain
IPR007110 Immunoglobulin-like domainDomainDomain
IPR013320 Concanavalin A-like lectin/glucanase domain superfamilyFamilyHomologous superfamily
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR016130 Protein-tyrosine phosphatase, active siteSiteActive site
IPR029021 Protein-tyrosine phosphatase-likeFamilyHomologous superfamily
IPR036116 Fibronectin type III superfamilyFamilyHomologous superfamily
IPR036179 Immunoglobulin-like domain superfamilyFamilyHomologous superfamily
IPR041201 PTPRJ, transmembrane domainDomainDomain

Diseases

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