Entity Details

Primary name SORL_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ92673
EntryNameSORL_HUMAN
FullNameSortilin-related receptor
TaxID9606
Evidenceevidence at protein level
Length2214
SequenceStatuscomplete
DateCreated2000-12-01
DateModified2021-06-02

Ontological Relatives

GenesSORL1

GO terms

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GOName
GO:0000139 Golgi membrane
GO:0001540 amyloid-beta binding
GO:0002024 diet induced thermogenesis
GO:0004888 transmembrane signaling receptor activity
GO:0005041 low-density lipoprotein particle receptor activity
GO:0005615 extracellular space
GO:0005641 nuclear envelope lumen
GO:0005768 endosome
GO:0005769 early endosome
GO:0005771 multivesicular body
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0005802 trans-Golgi network
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006605 protein targeting
GO:0006622 protein targeting to lysosome
GO:0006892 post-Golgi vesicle-mediated transport
GO:0006898 receptor-mediated endocytosis
GO:0007218 neuropeptide signaling pathway
GO:0009986 cell surface
GO:0010008 endosome membrane
GO:0010897 negative regulation of triglyceride catabolic process
GO:0014910 regulation of smooth muscle cell migration
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030169 low-density lipoprotein particle binding
GO:0030514 negative regulation of BMP signaling pathway
GO:0030658 transport vesicle membrane
GO:0031267 small GTPase binding
GO:0031333 negative regulation of protein-containing complex assembly
GO:0031901 early endosome membrane
GO:0031985 Golgi cisterna
GO:0032091 negative regulation of protein binding
GO:0032585 multivesicular body membrane
GO:0034067 protein localization to Golgi apparatus
GO:0038020 insulin receptor recycling
GO:0042923 neuropeptide binding
GO:0043407 negative regulation of MAP kinase activity
GO:0045053 protein retention in Golgi apparatus
GO:0045732 positive regulation of protein catabolic process
GO:0046628 positive regulation of insulin receptor signaling pathway
GO:0050768 negative regulation of neurogenesis
GO:0051604 protein maturation
GO:0055037 recycling endosome
GO:0055038 recycling endosome membrane
GO:0070062 extracellular exosome
GO:0070863 positive regulation of protein exit from endoplasmic reticulum
GO:0097356 perinucleolar compartment
GO:1900168 positive regulation of glial cell-derived neurotrophic factor production
GO:1901215 negative regulation of neuron death
GO:1902430 negative regulation of amyloid-beta formation
GO:1902771 positive regulation of choline O-acetyltransferase activity
GO:1902948 negative regulation of tau-protein kinase activity
GO:1902953 positive regulation of ER to Golgi vesicle-mediated transport
GO:1902955 positive regulation of early endosome to recycling endosome transport
GO:1902960 negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
GO:1902963 negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process
GO:1902966 positive regulation of protein localization to early endosome
GO:1902997 negative regulation of neurofibrillary tangle assembly
GO:1904179 positive regulation of adipose tissue development
GO:1990000 amyloid fibril formation
GO:1990845 adaptive thermogenesis
GO:2001137 positive regulation of endocytic recycling

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasmic vesicle
Early endosome membrane
Endoplasmic reticulum membrane
Endosome
Endosome membrane
Golgi apparatus
Golgi apparatus membrane
Recycling endosome membrane
Secreted

Domains

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DomainNameCategoryType
IPR000033 LDLR class B repeatRepeatRepeat
IPR002172 Low-density lipoprotein (LDL) receptor class A repeatRepeatRepeat
IPR003961 Fibronectin type IIIDomainDomain
IPR006581 VPS10DomainDomain
IPR011042 Six-bladed beta-propeller, TolB-likeFamilyHomologous superfamily
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR015943 WD40/YVTN repeat-like-containing domain superfamilyFamilyHomologous superfamily
IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved siteSiteConserved site
IPR031777 Sortilin, C-terminalDomainDomain
IPR031778 Sortilin, N-terminalDomainDomain
IPR036055 LDL receptor-like superfamilyFamilyHomologous superfamily
IPR036116 Fibronectin type III superfamilyFamilyHomologous superfamily

Diseases

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Interactions

28 interactions

InteractorPartnerSourcesPublicationsLink
SORL_HUMANGGA1_HUMANBioGRID, HPRD, MINT, UniProt11821067 17855360 20015111 26053850 30679749 details
SORL_HUMANGGA2_HUMANBioGRID, HPRD, IntAct, MINT, UniProt11821067 30679749 32814053 details
SORL_HUMANPP1A_HUMANBioGRID, IntAct22321011 details
SORL_HUMANAMRP_HUMANbhf-ucl, BioGRID, HPRD, IntAct11294867 11557679 17326667 26858303 28514442 8940146 details
SORL_HUMANAPOE_HUMANbhf-ucl, BioGRID11294867 17326667 details
SORL_HUMANDDT4L_HUMANIntAct32296183 details
SORL_HUMANRHOH_HUMANBioGRID, IntAct32296183 details
SORL_HUMANPO6F2_HUMANBioGRID, IntAct32296183 details
SORL_HUMANA4_HUMANBioGRID, IntAct, UniProt16174740 16407538 17855360 23283322 32814053 details
SORL_HUMANHS12A_HUMANBioGRID, UniProt30679749 details
SORL_HUMANCRLF1_HUMANIntAct26858303 details
SORL_HUMANCNTFR_HUMANIntAct26858303 details
SORL_HUMANIL6_HUMANIntAct28265003 details
SORL_HUMANIL6RA_HUMANIntAct28265003 details
SORL_HUMANGDNF_HUMANIntAct23333276 details
SORL_HUMANGFRA1_HUMANIntAct23333276 details
SORL_HUMANACHA4_HUMANIntAct32814053 details
SORL_HUMANNDUV2_HUMANIntAct32814053 details
SORL_HUMANCBX1_HUMANIntAct32814053 details
SORL_HUMANPNPH_HUMANIntAct32814053 details
SORL_HUMANIF2B_HUMANIntAct32814053 details
SORL_HUMANKAT5_HUMANIntAct32814053 details
SORL_HUMANSORT_HUMANBioGRID11294867 details
SORL_HUMANSORL_HUMANBioGRID11294867 details
SORL_HUMANCEP97_HUMANBioGRID, IntAct27173435 unassigned1312 details
SORL_HUMANRET_HUMANIntAct23333276 details
SORL_HUMANPACS1_HUMANBioGRID17855360 details
SORL_HUMANFURIN_HUMANHPRD11294867 details