Entity Details

Primary name PROX1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ92786
EntryNamePROX1_HUMAN
FullNameProspero homeobox protein 1
TaxID9606
Evidenceevidence at protein level
Length737
SequenceStatuscomplete
DateCreated1998-07-15
DateModified2021-06-02

Ontological Relatives

GenesPROX1

GO terms

Show/Hide Table
GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000976 transcription cis-regulatory region binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0001709 cell fate determination
GO:0001822 kidney development
GO:0001889 liver development
GO:0001938 positive regulation of endothelial cell proliferation
GO:0001946 lymphangiogenesis
GO:0002088 lens development in camera-type eye
GO:0002194 hepatocyte cell migration
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006357 regulation of transcription by RNA polymerase II
GO:0007420 brain development
GO:0007623 circadian rhythm
GO:0008284 positive regulation of cell population proliferation
GO:0008285 negative regulation of cell population proliferation
GO:0010468 regulation of gene expression
GO:0010595 positive regulation of endothelial cell migration
GO:0016922 nuclear receptor binding
GO:0021516 dorsal spinal cord development
GO:0021542 dentate gyrus development
GO:0021707 cerebellar granule cell differentiation
GO:0021915 neural tube development
GO:0030240 skeletal muscle thin filament assembly
GO:0030324 lung development
GO:0030910 olfactory placode formation
GO:0031016 pancreas development
GO:0031667 response to nutrient levels
GO:0042752 regulation of circadian rhythm
GO:0043049 otic placode formation
GO:0043433 negative regulation of DNA-binding transcription factor activity
GO:0045071 negative regulation of viral genome replication
GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045787 positive regulation of cell cycle
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046619 lens placode formation involved in camera-type eye formation
GO:0048845 venous blood vessel morphogenesis
GO:0050692 DNA binding domain binding
GO:0050693 LBD domain binding
GO:0055005 ventricular cardiac myofibril assembly
GO:0055009 atrial cardiac muscle tissue morphogenesis
GO:0055010 ventricular cardiac muscle tissue morphogenesis
GO:0060042 retina morphogenesis in camera-type eye
GO:0060059 embryonic retina morphogenesis in camera-type eye
GO:0060214 endocardium formation
GO:0060298 positive regulation of sarcomere organization
GO:0060412 ventricular septum morphogenesis
GO:0060414 aorta smooth muscle tissue morphogenesis
GO:0060421 positive regulation of heart growth
GO:0060836 lymphatic endothelial cell differentiation
GO:0060838 lymphatic endothelial cell fate commitment
GO:0061114 branching involved in pancreas morphogenesis
GO:0070309 lens fiber cell morphogenesis
GO:0070365 hepatocyte differentiation
GO:0070858 negative regulation of bile acid biosynthetic process
GO:0072574 hepatocyte proliferation
GO:0090425 acinar cell differentiation
GO:0097150 neuronal stem cell population maintenance
GO:1901978 positive regulation of cell cycle checkpoint
GO:1990837 sequence-specific double-stranded DNA binding
GO:2000179 positive regulation of neural precursor cell proliferation
GO:2000979 positive regulation of forebrain neuron differentiation

Subcellular Location

Show/Hide Table
Subcellular Location
Nucleus

Domains

Show/Hide Table
DomainNameCategoryType
IPR007738 Prospero homeobox protein 1FamilyFamily
IPR009057 Homeobox-like domain superfamilyFamilyHomologous superfamily
IPR023082 Homeo-prospero domainDomainDomain
IPR037131 Homeo-prospero domain superfamilyFamilyHomologous superfamily
IPR039350 Prospero homeodomain familyFamilyFamily

Diseases

Show/Hide Table