Entity Details

Primary name RAD50_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ92878
EntryNameRAD50_HUMAN
FullNameDNA repair protein RAD50
TaxID9606
Evidenceevidence at protein level
Length1312
SequenceStatuscomplete
DateCreated2005-02-01
DateModified2021-06-02

Ontological Relatives

GenesRAD50

GO terms

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GOName
GO:0000019 regulation of mitotic recombination
GO:0000722 telomere maintenance via recombination
GO:0000723 telomere maintenance
GO:0000724 double-strand break repair via homologous recombination
GO:0000729 DNA double-strand break processing
GO:0000781 chromosome, telomeric region
GO:0000794 condensed nuclear chromosome
GO:0003677 DNA binding
GO:0003691 double-stranded telomeric DNA binding
GO:0005524 ATP binding
GO:0005654 nucleoplasm
GO:0006260 DNA replication
GO:0006281 DNA repair
GO:0006302 double-strand break repair
GO:0006303 double-strand break repair via nonhomologous end joining
GO:0006310 DNA recombination
GO:0006974 cellular response to DNA damage stimulus
GO:0007004 telomere maintenance via telomerase
GO:0007131 reciprocal meiotic recombination
GO:0016020 membrane
GO:0016032 viral process
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0030674 protein-macromolecule adaptor activity
GO:0030870 Mre11 complex
GO:0031860 telomeric 3' overhang formation
GO:0031954 positive regulation of protein autophosphorylation
GO:0032206 positive regulation of telomere maintenance
GO:0032508 DNA duplex unwinding
GO:0033674 positive regulation of kinase activity
GO:0035861 site of double-strand break
GO:0042802 identical protein binding
GO:0043047 single-stranded telomeric DNA binding
GO:0046872 metal ion binding
GO:0051880 G-quadruplex DNA binding
GO:0070192 chromosome organization involved in meiotic cell cycle
GO:0090305 nucleic acid phosphodiester bond hydrolysis
GO:1901796 regulation of signal transduction by p53 class mediator
GO:1904354 negative regulation of telomere capping

Subcellular Location

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Subcellular Location
Chromosome
Nucleus

Domains

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DomainNameCategoryType
IPR004584 DNA repair protein Rad50, eukaryotesFamilyFamily
IPR013134 RAD50, zinc hookDomainDomain
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR038729 Rad50/SbcC-type AAA domainDomainDomain

Diseases

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Interactions

64 interactions

InteractorPartnerSourcesPublicationsLink
RAD50_HUMANMDC1_HUMANBioGRID, MINT, UniProt12607003 12607005 14519663 18583988 29656893 30179224 details
RAD50_HUMANNBN_HUMANBioGRID, HPRD, MINT, UniProt10426999 10783165 11062235 11238951 12124328 12447395 12607003 12679336 15734743 15758953 16391231 17500065 17612497 19197236 22464731 22939629 22941933 23530059 24651726 24981860 26215093 26344197 30179224 30440001 9705271 details
RAD50_HUMANEP300_HUMANBioGRID, HPRD, MINT16051665 20808282 details
RAD50_HUMANTP53B_HUMANBioGRID, UniProt20010693 29656893 details
RAD50_HUMANBRCA1_HUMANBioGRID, UniProt10426999 10783165 11504724 12124328 16391231 18171670 25084169 25184681 29656893 details
RAD50_HUMANRAD50_HUMANBioGRID, DIP28134932 details
RAD50_HUMANRINT1_HUMANBioGRID, HPRD11096100 16600870 details
RAD50_HUMANRECQ5_HUMANBioGRID19270065 details
RAD50_HUMANGEMI2_HUMANBioGRID20403813 details
RAD50_HUMANSUMO2_HUMANBioGRID19394292 32786267 details
RAD50_HUMANCBP_HUMANBioGRID32238831 details
RAD50_HUMANTE2IP_HUMANBioGRID, HPRD, IntAct15100233 15383534 22939629 details
RAD50_HUMANH2AX_HUMANBioGRID, DIP, IntAct, MINT10959836 15201865 16377563 18583988 19234442 31501894 details
RAD50_HUMANMRE11_HUMANBioGRID, DIP, HPRD, IntAct, MINT, UniProt10508516 10783165 10888888 11062235 11504724 12607003 12750284 15734743 16163361 16391231 17500065 17694070 19197236 19270065 22939629 23530059 24413181 24651726 24981860 26215093 26344197 26455393 27173435 28363998 28369484 30179224 30733337 31501894 8756642 9705271 unassigned1312 details
RAD50_HUMANATRX_HUMANBioGRID, UniProt23329831 24651726 details
RAD50_HUMANRAD17_HUMANMINT24534091 details
RAD50_HUMANCF161_HUMANBioGRID, IntAct27173435 unassigned1312 details
RAD50_HUMANCC150_HUMANBioGRID, IntAct27173435 unassigned1312 details
RAD50_HUMANTERF2_HUMANBioGRID, DIP10888888 15100233 18212065 19287395 22939629 details
RAD50_HUMANCTIP_HUMANBioGRID, DIP16391231 25558984 27940557 31636387 details
RAD50_HUMANMIPT3_HUMANIntAct31413325 details
RAD50_HUMANBLM_HUMANBioGRID10783165 25084169 29523790 details
RAD50_HUMANATM_HUMANBioGRID10783165 details
RAD50_HUMANMLH1_HUMANBioGRID10783165 details
RAD50_HUMANMSH2_HUMANBioGRID10783165 details
RAD50_HUMANMSH6_HUMANBioGRID10783165 details
RAD50_HUMANRFC1_HUMANBioGRID10783165 details
RAD50_HUMANDDX1_HUMANBioGRID18710941 details
RAD50_HUMANPHF1_HUMANBioGRID18385154 details
RAD50_HUMANPAXI1_HUMANBioGRID17500065 17925232 details
RAD50_HUMANDCR1B_HUMANBioGRID18469862 details
RAD50_HUMANKAT5_HUMANBioGRID20070254 details
RAD50_HUMANTERF1_HUMANBioGRID20811636 details
RAD50_HUMANHDAC5_HUMANBioGRID21081666 details
RAD50_HUMANBARD1_HUMANBioGRID16391231 details
RAD50_HUMANSMRCD_HUMANBioGRID21549307 details
RAD50_HUMANSKP2_HUMANBioGRID22464731 details
RAD50_HUMANMDM2_HUMANBioGRID15734743 details
RAD50_HUMANDCR1C_HUMANBioGRID, HPRD15456891 31900314 details
RAD50_HUMANRBL2_HUMANBioGRID16600870 details
RAD50_HUMANRNF8_HUMANBioGRID23115235 details
RAD50_HUMANSIR6_HUMANBioGRID24169447 details
RAD50_HUMANMDM4_HUMANBioGRID24608433 details
RAD50_HUMANUBP4_HUMANBioGRID26455393 details
RAD50_HUMANRN126_HUMANBioGRID26508657 details
RAD50_HUMANH31T_HUMANBioGRID25823024 details
RAD50_HUMANFANCJ_HUMANBioGRID23530059 details
RAD50_HUMANSPTA1_HUMANBioGRID16889989 details
RAD50_HUMANHDAC6_HUMANBioGRID24882211 details
RAD50_HUMANMCM9_HUMANBioGRID26215093 details
RAD50_HUMANMCM8_HUMANBioGRID26215093 details
RAD50_HUMANRN169_HUMANBioGRID30104380 details
RAD50_HUMANUBP7_HUMANBioGRID30179224 details
RAD50_HUMANRECQ4_HUMANBioGRID29229926 details
RAD50_HUMANDYL1_HUMANBioGRID30464262 details
RAD50_HUMANTRI29_HUMANBioGRID26095369 details
RAD50_HUMANWDHD1_HUMANBioGRID27940557 details
RAD50_HUMANPPARG_HUMANBioGRID30699358 details
RAD50_HUMANCDK2_HUMANBioGRID22231403 details
RAD50_HUMANBRCA2_HUMANBioGRID20010693 details
RAD50_HUMANPELI1_HUMANBioGRID30952868 details
RAD50_HUMANNALP2_HUMANBioGRID28345663 details
RAD50_HUMANERPG3_HUMANBioGRID31501894 details
RAD50_HUMANERCC6_HUMANBioGRID31501894 details