Entity Details

Primary name EME1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ96AY2
EntryNameEME1_HUMAN
FullNameCrossover junction endonuclease EME1
TaxID9606
Evidenceevidence at protein level
Length570
SequenceStatuscomplete
DateCreated2006-02-21
DateModified2021-06-02

Ontological Relatives

GenesEME1

GO terms

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GOName
GO:0000712 resolution of meiotic recombination intermediates
GO:0000792 heterochromatin
GO:0003677 DNA binding
GO:0004519 endonuclease activity
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0006302 double-strand break repair
GO:0031297 replication fork processing
GO:0031573 mitotic intra-S DNA damage checkpoint signaling
GO:0036297 interstrand cross-link repair
GO:0046872 metal ion binding
GO:0048476 Holliday junction resolvase complex
GO:0072429 response to intra-S DNA damage checkpoint signaling

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR006166 ERCC4 domainDomainDomain
IPR033310 Mms4/EME1/EME2FamilyFamily
IPR042530 EME1/EME2, C-terminal domainFamilyHomologous superfamily
IPR043086 EME1, nuclease domain, subdomain 1FamilyHomologous superfamily
IPR043087 ERCC4, Mus81-Eme1 complex, nuclease domain, subdomain 2FamilyHomologous superfamily

Diseases

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