Entity Details

Primary name SFRP2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ96HF1
EntryNameSFRP2_HUMAN
FullNameSecreted frizzled-related protein 2
TaxID9606
Evidenceevidence at protein level
Length295
SequenceStatuscomplete
DateCreated2005-03-15
DateModified2021-06-02

Ontological Relatives

GenesSFRP2

GO terms

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GOName
GO:0001569 branching involved in blood vessel morphogenesis
GO:0001968 fibronectin binding
GO:0002063 chondrocyte development
GO:0003151 outflow tract morphogenesis
GO:0003214 cardiac left ventricle morphogenesis
GO:0005178 integrin binding
GO:0005615 extracellular space
GO:0006915 apoptotic process
GO:0007267 cell-cell signaling
GO:0007584 response to nutrient
GO:0008047 enzyme activator activity
GO:0008284 positive regulation of cell population proliferation
GO:0008285 negative regulation of cell population proliferation
GO:0008584 male gonad development
GO:0010629 negative regulation of gene expression
GO:0010667 negative regulation of cardiac muscle cell apoptotic process
GO:0010719 negative regulation of epithelial to mesenchymal transition
GO:0010975 regulation of neuron projection development
GO:0017147 Wnt-protein binding
GO:0030178 negative regulation of Wnt signaling pathway
GO:0030199 collagen fibril organization
GO:0030307 positive regulation of cell growth
GO:0030308 negative regulation of cell growth
GO:0030336 negative regulation of cell migration
GO:0030514 negative regulation of BMP signaling pathway
GO:0031668 cellular response to extracellular stimulus
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0033630 positive regulation of cell adhesion mediated by integrin
GO:0036342 post-anal tail morphogenesis
GO:0042493 response to drug
GO:0042662 negative regulation of mesodermal cell fate specification
GO:0042733 embryonic digit morphogenesis
GO:0043065 positive regulation of apoptotic process
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043508 negative regulation of JUN kinase activity
GO:0045600 positive regulation of fat cell differentiation
GO:0045669 positive regulation of osteoblast differentiation
GO:0045766 positive regulation of angiogenesis
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048018 receptor ligand activity
GO:0048546 digestive tract morphogenesis
GO:0050680 negative regulation of epithelial cell proliferation
GO:0050732 negative regulation of peptidyl-tyrosine phosphorylation
GO:0060028 convergent extension involved in axis elongation
GO:0060070 canonical Wnt signaling pathway
GO:0060349 bone morphogenesis
GO:0061056 sclerotome development
GO:0061133 endopeptidase activator activity
GO:0061185 negative regulation of dermatome development
GO:0062023 collagen-containing extracellular matrix
GO:0071425 hematopoietic stem cell proliferation
GO:0071481 cellular response to X-ray
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0090179 planar cell polarity pathway involved in neural tube closure
GO:0090244 Wnt signaling pathway involved in somitogenesis
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
GO:1904956 regulation of midbrain dopaminergic neuron differentiation
GO:2000035 regulation of stem cell division
GO:2000041 negative regulation of planar cell polarity pathway involved in axis elongation

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR001134 Netrin domainDomainDomain
IPR008993 Tissue inhibitor of metalloproteinases-like, OB-foldFamilyHomologous superfamily
IPR015526 Frizzled/secreted frizzled-related proteinFamilyFamily
IPR018933 Netrin module, non-TIMP typeDomainDomain
IPR020067 Frizzled domainDomainDomain
IPR026558 Secreted frizzled-related protein 2FamilyFamily
IPR036790 Frizzled cysteine-rich domain superfamilyFamilyHomologous superfamily
IPR041764 SFRP2, cysteine-rich domainDomainDomain

Diseases

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