Entity Details

Primary name HCD2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ99714
EntryNameHCD2_HUMAN
FullName3-hydroxyacyl-CoA dehydrogenase type-2
TaxID9606
Evidenceevidence at protein level
Length261
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesHSD17B10

GO terms

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GOName
GO:0000049 tRNA binding
GO:0003723 RNA binding
GO:0003857 3-hydroxyacyl-CoA dehydrogenase activity
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0005886 plasma membrane
GO:0006550 isoleucine catabolic process
GO:0006629 lipid metabolic process
GO:0006635 fatty acid beta-oxidation
GO:0006699 bile acid biosynthetic process
GO:0007005 mitochondrion organization
GO:0008207 C21-steroid hormone metabolic process
GO:0008209 androgen metabolic process
GO:0008210 estrogen metabolic process
GO:0008709 cholate 7-alpha-dehydrogenase activity
GO:0009083 branched-chain amino acid catabolic process
GO:0030283 testosterone dehydrogenase [NAD(P)] activity
GO:0030678 mitochondrial ribonuclease P complex
GO:0042645 mitochondrial nucleoid
GO:0044594 17-beta-hydroxysteroid dehydrogenase (NAD+) activity
GO:0047015 3-hydroxy-2-methylbutyryl-CoA dehydrogenase activity
GO:0047035 testosterone dehydrogenase (NAD+) activity
GO:0047044 androstan-3-alpha,17-beta-diol dehydrogenase activity
GO:0051289 protein homotetramerization
GO:0062173 brexanolone metabolic process
GO:0070901 mitochondrial tRNA methylation
GO:0097745 mitochondrial tRNA 5'-end processing
GO:0106281 chenodeoxycholate 7-alpha-dehydrogenase (NAD+) activity
GO:0106282 isoursodeoxycholate 7-beta-dehydrogenase (NAD+) activity
GO:0106283 ursodeoxycholate 7-beta-dehydrogenase (NAD+) activity
GO:1990180 mitochondrial tRNA 3'-end processing

Subcellular Location

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Subcellular Location
Mitochondrion
Mitochondrion matrix

Domains

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DomainNameCategoryType
IPR002347 Short-chain dehydrogenase/reductase SDRFamilyFamily
IPR020904 Short-chain dehydrogenase/reductase, conserved siteSiteConserved site
IPR036291 NAD(P)-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00157 NADHDrugbanksmall molecule
DB02820 1-Azepan-1-Yl-2-Phenyl-2-(4-Thioxo-1,4-Dihydro-Pyrazolo[3,4-D]Pyrimidin-5-Yl)Ethanone AdductDrugbanksmall molecule
DB09568 Omega-3-carboxylic acidsDrugbanksmall molecule

Interactions

40 interactions

InteractorPartnerSourcesPublicationsLink
HCD2_HUMANA4_HUMANBioGRID, HPRD, IntAct10371197 15087549 32814053 9338779 details
HCD2_HUMANTM10C_HUMANBioGRID, IntAct, UniProt18984158 28514442 29880640 details
HCD2_HUMANCHD3_HUMANBioGRID, MINT21900206 details
HCD2_HUMANFAF1_HUMANBioGRID, MINT21900206 details
HCD2_HUMANUB2D1_HUMANBioGRID, MINT21900206 details
HCD2_HUMANHCD2_HUMANDIP15342248 details
HCD2_HUMANPCNA_HUMANUniProt26030842 details
HCD2_HUMANHTRA2_HUMANBioGRID17266347 details
HCD2_HUMANALDOA_HUMANBioGRID22496890 26344197 details
HCD2_HUMANTOM40_HUMANBioGRID25591737 26344197 details
HCD2_HUMANPRKN_HUMANBioGRID25591737 details
HCD2_HUMANTOM20_HUMANBioGRID25591737 details
HCD2_HUMANPINK1_HUMANBioGRID25591737 31300519 details
HCD2_HUMANTOM22_HUMANBioGRID25591737 details
HCD2_HUMANODO1_HUMANBioGRID22496890 details
HCD2_HUMANAL3B1_HUMANBioGRID22496890 details
HCD2_HUMANATPA_HUMANBioGRID22496890 details
HCD2_HUMANCPSM_HUMANBioGRID22496890 details
HCD2_HUMANCISY_HUMANBioGRID22496890 32877691 34079125 details
HCD2_HUMANETFD_HUMANBioGRID22496890 details
HCD2_HUMANDHE3_HUMANBioGRID22496890 details
HCD2_HUMANHMGCL_HUMANBioGRID22496890 details
HCD2_HUMANHMCS2_HUMANBioGRID22496890 details
HCD2_HUMANODPA_HUMANBioGRID22496890 34079125 details
HCD2_HUMANODPB_HUMANBioGRID22496890 details
HCD2_HUMANODPX_HUMANBioGRID22496890 details
HCD2_HUMANECHA_HUMANBioGRID22496890 details
HCD2_HUMANECHB_HUMANBioGRID22496890 details
HCD2_HUMANGLNA_HUMANBioGRID22496890 details
HCD2_HUMANMDHC_HUMANBioGRID22496890 details
HCD2_HUMANPYGL_HUMANBioGRID22496890 details
HCD2_HUMANCIKS_HUMANBioGRID22496890 details
HCD2_HUMANTRAF5_HUMANBioGRID22496890 details
HCD2_HUMANTRAF6_HUMANBioGRID22496890 details
HCD2_HUMANPTEN_HUMANBioGRID31685992 details
HCD2_HUMANCDC42_HUMANBioGRID31478661 details
HCD2_HUMANHDAC5_HUMANBioGRID21081666 details
HCD2_HUMANITA4_HUMANBioGRID22623428 details
HCD2_HUMANGRSF1_HUMANBioGRID23473034 29395067 32877691 details
HCD2_HUMANATG5_HUMANBioGRID33024031 details