Entity Details

Primary name NPAS2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ99743
EntryNameNPAS2_HUMAN
FullNameNeuronal PAS domain-containing protein 2
TaxID9606
Evidenceevidence at protein level
Length824
SequenceStatuscomplete
DateCreated1998-12-15
DateModified2021-06-02

Ontological Relatives

GenesNPAS2

GO terms

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GOName
GO:0000785 chromatin
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription regulator complex
GO:0005829 cytosol
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006974 cellular response to DNA damage stimulus
GO:0007417 central nervous system development
GO:0007623 circadian rhythm
GO:0032922 circadian regulation of gene expression
GO:0042493 response to drug
GO:0045739 positive regulation of DNA repair
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046872 metal ion binding
GO:0046983 protein dimerization activity
GO:0051775 response to redox state
GO:0051879 Hsp90 protein binding
GO:0060548 negative regulation of cell death
GO:1990513 CLOCK-BMAL transcription complex
GO:1990837 sequence-specific double-stranded DNA binding
GO:2000987 positive regulation of behavioral fear response
GO:2001020 regulation of response to DNA damage stimulus

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR000014 PAS domainDomainDomain
IPR001067 Nuclear translocatorFamilyFamily
IPR001610 PAC motifRepeatRepeat
IPR011598 Myc-type, basic helix-loop-helix (bHLH) domainDomainDomain
IPR013767 PAS foldDomainDomain
IPR035965 PAS domain superfamilyFamilyHomologous superfamily
IPR036638 Helix-loop-helix DNA-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

32 interactions

InteractorPartnerSourcesPublicationsLink
NPAS2_HUMANRL6_HUMANBioGRID, IntAct21988832 details
NPAS2_HUMANCSK2B_HUMANBioGRID, IntAct23555304 details
NPAS2_HUMANBHE40_HUMANIntAct23555304 details
NPAS2_HUMANRORG_HUMANBioGRID, IntAct23555304 details
NPAS2_HUMANRASF7_HUMANBioGRID, IntAct24722188 details
NPAS2_HUMANHGS_HUMANBioGRID, IntAct24722188 details
NPAS2_HUMANEFS_HUMANBioGRID, IntAct24722188 details
NPAS2_HUMANCRX_HUMANBioGRID, IntAct24722188 details
NPAS2_HUMANBMAL2_HUMANBioGRID, IntAct24722188 28514442 32296183 details
NPAS2_HUMANBMAL1_HUMANBioGRID, HPRD, IntAct11439184 20211142 23555304 24722188 28514442 32296183 9576906 details
NPAS2_HUMANNCK2_HUMANBioGRID, IntAct32296183 details
NPAS2_HUMANINCA1_HUMANBioGRID, IntAct32296183 details
NPAS2_HUMANUBAP2_HUMANBioGRID, IntAct32296183 details
NPAS2_HUMANNGLY1_HUMANBioGRID, IntAct32296183 details
NPAS2_HUMANBPIA1_HUMANBioGRID, IntAct32296183 details
NPAS2_HUMANFGFR3_HUMANIntAct32814053 details
NPAS2_HUMANNMDE3_HUMANIntAct32814053 details
NPAS2_HUMANRHXF1_HUMANBioGRID, IntAct20211142 details
NPAS2_HUMANZSCA1_HUMANBioGRID, IntAct20211142 details
NPAS2_HUMANHESX1_HUMANBioGRID, IntAct20211142 details
NPAS2_HUMANEP300_HUMANBioGRID, HPRD14645221 details
NPAS2_HUMANNCOA3_HUMANBioGRID, HPRD14645221 details
NPAS2_HUMANKAT2B_HUMANBioGRID, HPRD14645221 details
NPAS2_HUMANCBP_HUMANBioGRID, HPRD14645221 details
NPAS2_HUMANRXRA_HUMANBioGRID, HPRD11439184 details
NPAS2_HUMANRARA_HUMANBioGRID, HPRD11439184 details
NPAS2_HUMANHS90A_HUMANBioGRID, HPRD9079689 details
NPAS2_HUMANTRAF4_HUMANBioGRID16969126 details
NPAS2_HUMANARNT2_HUMANBioGRID24722188 details
NPAS2_HUMANCLOCK_HUMANBioGRID23555304 details
NPAS2_HUMANCRY1_HUMANBioGRID23555304 details
NPAS2_HUMANCRY2_HUMANBioGRID23555304 details