Entity Details
| Primary name |
ODC_HUMAN |
| Entity type |
UniProt |
| Source |
Source Link |
Details
| Accession | Q9BQT8 |
| EntryName | ODC_HUMAN |
| FullName | Mitochondrial 2-oxodicarboxylate carrier |
| TaxID | 9606 |
| Evidence | evidence at protein level |
| Length | 299 |
| SequenceStatus | complete |
| DateCreated | 2002-02-11 |
| DateModified | 2021-06-02 |
GO terms
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| GO | Name |
| GO:0005743 | mitochondrial inner membrane |
| GO:0006554 | lysine catabolic process |
| GO:0015139 | alpha-ketoglutarate transmembrane transporter activity |
| GO:0016021 | integral component of membrane |
| GO:1990550 | mitochondrial alpha-ketoglutarate transmembrane transport |
Subcellular Location
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| Subcellular Location |
| Mitochondrion inner membrane |
Domains
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| Domain | Name | Category | Type |
| IPR002067 | Mitochondrial carrier protein | Family | Family |
| IPR018108 | Mitochondrial substrate/solute carrier | Repeat | Repeat |
| IPR023395 | Mitochondrial carrier domain superfamily | Family | Homologous superfamily |
Diseases
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| Disease ID | Source | Name | Description |
| 618811 | OMIM | Mitochondrial DNA depletion syndrome 18 (MTDPS18) | An autosomal recessive mitochondrial disorder characterized by early-onset progressive weakness and atrophy of the distal limb muscles, loss of ambulation, and atrophy of the intrinsic hand muscles with clawed hands. Additional features include scoliosis, hypo- or hyperreflexia, and decreased pulmonary vital capacity. Examination of skeletal muscle shows mitochondrial respiratory chain deficiencies involving complexes I and IV, associated with mtDNA depletion. The disease may be caused by variants affecting the gene represented in this entry. |
Drugs
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| Drug | Name | Source | Type |
| DB09154 | Sodium citrate | Swissprot | small molecule |
Interactions
0 interactions
| Interactor | Partner | Sources | Publications | Link |