Entity Details

Primary name EFC4B_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9BSW2
EntryNameEFC4B_HUMAN
FullNameEF-hand calcium-binding domain-containing protein 4B
TaxID9606
Evidenceevidence at protein level
Length731
SequenceStatuscomplete
DateCreated2007-04-03
DateModified2021-06-02

Ontological Relatives

GenesCRACR2A

GO terms

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GOName
GO:0000139 Golgi membrane
GO:0001772 immunological synapse
GO:0002115 store-operated calcium entry
GO:0002250 adaptive immune response
GO:0003924 GTPase activity
GO:0005509 calcium ion binding
GO:0005525 GTP binding
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0005815 microtubule organizing center
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016197 endosomal transport
GO:0031982 vesicle
GO:0032237 activation of store-operated calcium channel activity
GO:0032588 trans-Golgi network membrane
GO:0033093 Weibel-Palade body
GO:0034776 response to histamine
GO:0035580 specific granule lumen
GO:0043312 neutrophil degranulation
GO:0045063 T-helper 1 cell differentiation
GO:0046330 positive regulation of JNK cascade
GO:0051928 positive regulation of calcium ion transport

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm
Golgi apparatus
Golgi apparatus membrane
Vesicle

Domains

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DomainNameCategoryType
IPR001806 Small GTPaseFamilyFamily
IPR002048 EF-hand domainDomainDomain
IPR005225 Small GTP-binding protein domainDomainDomain
IPR011992 EF-hand domain pairFamilyHomologous superfamily
IPR018247 EF-Hand 1, calcium-binding siteSiteBinding site
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily

Diseases

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Interactions

42 interactions

InteractorPartnerSourcesPublicationsLink
EFC4B_HUMANTRI29_HUMANBioGRID, HPRD, IntAct16189514 details
EFC4B_HUMANATN1_HUMANBioGRID, HPRD, IntAct16713569 details
EFC4B_HUMANCRCM1_HUMANUniProt20418871 details
EFC4B_HUMANSTIM1_HUMANUniProt20418871 details
EFC4B_HUMANTLE5_HUMANBioGRID, IntAct25416956 31515488 32296183 details
EFC4B_HUMANMKRN3_HUMANBioGRID, IntAct25416956 details
EFC4B_HUMANNT2NA_HUMANBioGRID, IntAct25416956 details
EFC4B_HUMANCDC23_HUMANBioGRID, IntAct25416956 details
EFC4B_HUMANTRAF1_HUMANBioGRID, IntAct32296183 details
EFC4B_HUMANVINEX_HUMANBioGRID, IntAct32296183 details
EFC4B_HUMANDDIT3_HUMANBioGRID, IntAct32296183 details
EFC4B_HUMANK2C75_HUMANBioGRID, IntAct32296183 details
EFC4B_HUMANTRIM1_HUMANBioGRID, IntAct32296183 details
EFC4B_HUMANCCHCR_HUMANBioGRID, IntAct32296183 details
EFC4B_HUMANGOGA2_HUMANBioGRID, IntAct32296183 details
EFC4B_HUMANMDFI_HUMANBioGRID, IntAct32296183 details
EFC4B_HUMANPNMA5_HUMANBioGRID, IntAct32296183 details
EFC4B_HUMANKR195_HUMANBioGRID, IntAct32296183 details
EFC4B_HUMANUBP2_HUMANBioGRID, IntAct32296183 details
EFC4B_HUMANLRIF1_HUMANBioGRID, IntAct32296183 details
EFC4B_HUMANFKBP6_HUMANBioGRID, IntAct32296183 details
EFC4B_HUMANRORB_HUMANIntAct32296183 details
EFC4B_HUMANMS18B_HUMANBioGRID, IntAct32296183 details
EFC4B_HUMANZN655_HUMANBioGRID, IntAct32296183 details
EFC4B_HUMANFA156_HUMANBioGRID, IntAct32296183 details
EFC4B_HUMANZNF20_HUMANBioGRID, IntAct32296183 details
EFC4B_HUMANANR29_HUMANBioGRID, IntAct32296183 details
EFC4B_HUMANRBAK_HUMANBioGRID, IntAct32296183 details
EFC4B_HUMANGGYF1_HUMANIntAct32296183 details
EFC4B_HUMANK1H1_HUMANBioGRID, IntAct32296183 details
EFC4B_HUMANF86C1_HUMANBioGRID, IntAct32296183 details
EFC4B_HUMANRPAC1_HUMANBioGRID, IntAct32296183 details
EFC4B_HUMANASB3_HUMANBioGRID, IntAct32296183 details
EFC4B_HUMANSLAI1_HUMANBioGRID, IntAct32296183 details
EFC4B_HUMANZC21C_HUMANBioGRID, IntAct32296183 details
EFC4B_HUMANKLF11_HUMANIntAct32814053 details
EFC4B_HUMANSPRE1_HUMANIntAct32814053 details
EFC4B_HUMANHD_HUMANIntAct32814053 details
EFC4B_HUMANNT2NC_HUMANBioGRID25416956 details
EFC4B_HUMANKR131_HUMANBioGRID32296183 details
EFC4B_HUMANORAI2_HUMANUniProt20418871 details
EFC4B_HUMANORAI3_HUMANUniProt20418871 details