Entity Details

Primary name INP5K_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9BT40
EntryNameINP5K_HUMAN
FullNameInositol polyphosphate 5-phosphatase K
TaxID9606
Evidenceevidence at protein level
Length448
SequenceStatuscomplete
DateCreated2003-09-26
DateModified2021-06-02

Ontological Relatives

GenesINPP5K

GO terms

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GOName
GO:0001701 in utero embryonic development
GO:0001726 ruffle
GO:0001933 negative regulation of protein phosphorylation
GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
GO:0004445 inositol-polyphosphate 5-phosphatase activity
GO:0005000 vasopressin receptor activity
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005802 trans-Golgi network
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005979 regulation of glycogen biosynthetic process
GO:0006469 negative regulation of protein kinase activity
GO:0006661 phosphatidylinositol biosynthetic process
GO:0007186 G protein-coupled receptor signaling pathway
GO:0010801 negative regulation of peptidyl-threonine phosphorylation
GO:0010829 negative regulation of glucose transmembrane transport
GO:0016020 membrane
GO:0016311 dephosphorylation
GO:0016312 inositol bisphosphate phosphatase activity
GO:0030036 actin cytoskeleton organization
GO:0032587 ruffle membrane
GO:0032869 cellular response to insulin stimulus
GO:0032870 cellular response to hormone stimulus
GO:0033137 negative regulation of peptidyl-serine phosphorylation
GO:0034485 phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity
GO:0034594 phosphatidylinositol trisphosphate phosphatase activity
GO:0034595 phosphatidylinositol phosphate 5-phosphatase activity
GO:0035305 negative regulation of dephosphorylation
GO:0035810 positive regulation of urine volume
GO:0042577 lipid phosphatase activity
GO:0042593 glucose homeostasis
GO:0043005 neuron projection
GO:0043407 negative regulation of MAP kinase activity
GO:0043922 negative regulation by host of viral transcription
GO:0045719 negative regulation of glycogen biosynthetic process
GO:0045869 negative regulation of single stranded viral RNA replication via double stranded DNA intermediate
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0046030 inositol trisphosphate phosphatase activity
GO:0046627 negative regulation of insulin receptor signaling pathway
GO:0046855 inositol phosphate dephosphorylation
GO:0046856 phosphatidylinositol dephosphorylation
GO:0048471 perinuclear region of cytoplasm
GO:0051497 negative regulation of stress fiber assembly
GO:0051898 negative regulation of protein kinase B signaling
GO:0051926 negative regulation of calcium ion transport
GO:0052658 inositol-1,4,5-trisphosphate 5-phosphatase activity
GO:0052659 inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity
GO:0071320 cellular response to cAMP
GO:0071356 cellular response to tumor necrosis factor
GO:0071364 cellular response to epidermal growth factor stimulus
GO:0072659 protein localization to plasma membrane
GO:0090315 negative regulation of protein targeting to membrane
GO:0097178 ruffle assembly
GO:2000466 negative regulation of glycogen (starch) synthase activity
GO:2001153 positive regulation of renal water transport

Subcellular Location

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Subcellular Location
Cytoplasm
Endoplasmic reticulum

Domains

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DomainNameCategoryType
IPR000300 Inositol polyphosphate-related phosphataseDomainDomain
IPR005135 Endonuclease/exonuclease/phosphataseDomainDomain
IPR036691 Endonuclease/exonuclease/phosphatase superfamilyFamilyHomologous superfamily
IPR041611 SKICH domainDomainDomain

Diseases

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Interactions

29 interactions

InteractorPartnerSourcesPublicationsLink
INP5K_HUMANAR6P1_HUMANBioGRID, HPRD, IntAct16189514 29892012 32296183 details
INP5K_HUMANLNX1_HUMANIntAct16002321 details
INP5K_HUMANBDNF_HUMANBioGRID, IntAct21988832 details
INP5K_HUMANTANK_HUMANBioGRID, IntAct21988832 details
INP5K_HUMANCPTP_HUMANBioGRID, IntAct21988832 details
INP5K_HUMANANXA7_HUMANBioGRID, MINT21900206 details
INP5K_HUMANCDN1A_HUMANBioGRID, MINT21900206 details
INP5K_HUMANHMOX2_HUMANBioGRID, MINT21900206 details
INP5K_HUMANPFD1_HUMANBioGRID, MINT21900206 details
INP5K_HUMANSMN_HUMANBioGRID, MINT21900206 details
INP5K_HUMANKITH_HUMANBioGRID, MINT21900206 details
INP5K_HUMANTTHY_HUMANBioGRID, MINT21900206 details
INP5K_HUMANHSPB1_HUMANBioGRID, IntAct25277244 details
INP5K_HUMANMD2BP_HUMANBioGRID, IntAct25416956 28514442 29892012 32296183 details
INP5K_HUMANK1H1_HUMANBioGRID, IntAct25416956 32296183 details
INP5K_HUMANFATE1_HUMANBioGRID, IntAct25416956 29892012 32296183 details
INP5K_HUMANFADS6_HUMANBioGRID, IntAct32296183 details
INP5K_HUMANTR10D_HUMANBioGRID, IntAct32296183 details
INP5K_HUMANATP5J_HUMANBioGRID, IntAct32296183 details
INP5K_HUMANGOT1B_HUMANBioGRID, IntAct32296183 details
INP5K_HUMANSFT2B_HUMANBioGRID, IntAct32296183 details
INP5K_HUMANKLK6_HUMANIntAct32814053 details
INP5K_HUMANNCOR2_HUMANBioGRID11509665 details
INP5K_HUMANFBX7_HUMANBioGRID27503909 details
INP5K_HUMANPBX3_HUMANBioGRID32296183 details
INP5K_HUMANEPIPL_HUMANIntAct17353931 details
INP5K_HUMANPDXD1_HUMANIntAct17353931 details
INP5K_HUMANDCD_HUMANIntAct17353931 details
INP5K_HUMANPYGM_HUMANIntAct17353931 details