Entity Details

Primary name NLRP1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9C000
EntryNameNLRP1_HUMAN
FullNameNACHT, LRR and PYD domains-containing protein 1
TaxID9606
Evidenceevidence at protein level
Length1473
SequenceStatuscomplete
DateCreated2001-10-18
DateModified2021-06-02

Ontological Relatives

GenesNLRP1

GO terms

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GOName
GO:0003690 double-stranded DNA binding
GO:0003725 double-stranded RNA binding
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0006915 apoptotic process
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006954 inflammatory response
GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0016032 viral process
GO:0016887 ATP hydrolysis activity
GO:0019899 enzyme binding
GO:0019904 protein domain specific binding
GO:0032495 response to muramyl dipeptide
GO:0032731 positive regulation of interleukin-1 beta production
GO:0042742 defense response to bacterium
GO:0042981 regulation of apoptotic process
GO:0050727 regulation of inflammatory response
GO:0051402 neuron apoptotic process
GO:0051607 defense response to virus
GO:0061702 inflammasome complex
GO:0070269 pyroptosis
GO:0072558 NLRP1 inflammasome complex
GO:0097264 self proteolysis
GO:0140374 antiviral innate immune response
GO:1904784 NLRP1 inflammasome complex assembly

Subcellular Location

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Subcellular Location
Cytoplasm
Inflammasome
Nucleus

Domains

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DomainNameCategoryType
IPR001315 CARD domainDomainDomain
IPR001611 Leucine-rich repeatRepeatRepeat
IPR004020 DAPIN domainDomainDomain
IPR007111 NACHT nucleoside triphosphataseDomainDomain
IPR011029 Death-like domain superfamilyFamilyHomologous superfamily
IPR025307 FIIND domainDomainDomain
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR032675 Leucine-rich repeat domain superfamilyFamilyHomologous superfamily
IPR033516 CARD8/ASC/NALP1, CARD domainDomainDomain
IPR041075 NOD2, winged helix domainDomainDomain
IPR041267 NACHT, LRR and PYD domains-containing protein, helical domain HD2DomainDomain

Diseases

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