Entity Details

Primary name NKX62_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9C056
EntryNameNKX62_HUMAN
FullNameHomeobox protein Nkx-6.2
TaxID9606
Evidenceevidence at protein level
Length277
SequenceStatuscomplete
DateCreated2007-09-11
DateModified2021-06-02

Ontological Relatives

GenesNKX6-2

GO terms

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GOName
GO:0000785 chromatin
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0005634 nucleus
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription by RNA polymerase II
GO:0010454 negative regulation of cell fate commitment
GO:0010455 positive regulation of cell fate commitment
GO:0022010 central nervous system myelination
GO:0030154 cell differentiation
GO:0031018 endocrine pancreas development
GO:0031641 regulation of myelination
GO:0045686 negative regulation of glial cell differentiation
GO:0045687 positive regulation of glial cell differentiation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0050885 neuromuscular process controlling balance
GO:1990837 sequence-specific double-stranded DNA binding

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR000047 Helix-turn-helix motifSiteConserved site
IPR001356 Homeobox domainDomainDomain
IPR009057 Homeobox-like domain superfamilyFamilyHomologous superfamily
IPR017970 Homeobox, conserved siteSiteConserved site
IPR020479 Homeobox domain, metazoaDomainDomain

Diseases

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Interactions

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