Entity Details

Primary name SIK2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9H0K1
EntryNameSIK2_HUMAN
FullNameSerine/threonine-protein kinase SIK2
TaxID9606
Evidenceevidence at protein level
Length926
SequenceStatuscomplete
DateCreated2005-02-15
DateModified2021-06-02

Ontological Relatives

GenesSIK2

GO terms

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GOName
GO:0000287 magnesium ion binding
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0006468 protein phosphorylation
GO:0035556 intracellular signal transduction
GO:0042149 cellular response to glucose starvation
GO:0046626 regulation of insulin receptor signaling pathway
GO:0046777 protein autophosphorylation
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR015940 Ubiquitin-associated domainDomainDomain
IPR017090 Serine/threonine-protein kinase, SIK1/2FamilyFamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR034672 Salt-Inducible kinase, catalytic domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB12010 FostamatinibDrugbanksmall molecule