Entity Details

Primary name CDT1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9H211
EntryNameCDT1_HUMAN
FullNameDNA replication factor Cdt1
TaxID9606
Evidenceevidence at protein level
Length546
SequenceStatuscomplete
DateCreated2004-12-07
DateModified2021-06-02

Ontological Relatives

GenesCDT1

GO terms

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GOName
GO:0000076 DNA replication checkpoint signaling
GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle
GO:0000278 mitotic cell cycle
GO:0000776 kinetochore
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0006270 DNA replication initiation
GO:0007059 chromosome segregation
GO:0016604 nuclear body
GO:0030174 regulation of DNA-dependent DNA replication initiation
GO:0031334 positive regulation of protein-containing complex assembly
GO:0033044 regulation of chromosome organization
GO:0033262 regulation of nuclear cell cycle DNA replication
GO:0035563 positive regulation of chromatin binding
GO:0036388 pre-replicative complex assembly
GO:0045740 positive regulation of DNA replication
GO:0051301 cell division
GO:0051315 attachment of mitotic spindle microtubules to kinetochore
GO:0051383 kinetochore organization
GO:0070182 DNA polymerase binding
GO:0071163 DNA replication preinitiation complex assembly
GO:0072708 response to sorbitol
GO:1902426 deactivation of mitotic spindle assembly checkpoint
GO:1902595 regulation of DNA replication origin binding
GO:1905341 negative regulation of protein localization to kinetochore
GO:1905342 positive regulation of protein localization to kinetochore
GO:2000105 positive regulation of DNA-dependent DNA replication

Subcellular Location

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Subcellular Location
Chromosome
Nucleus

Domains

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DomainNameCategoryType
IPR014939 CDT1 Geminin-binding domain-likeDomainDomain
IPR032054 DNA replication factor Cdt1, C-terminalDomainDomain
IPR036390 Winged helix DNA-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

51 interactions

InteractorPartnerSourcesPublicationsLink
CDT1_HUMANGEMI_HUMANBioGRID, DIP, HPRD, IntAct, MINT, UniProt11125146 14578910 14993212 15138268 15232106 15257290 15855168 16482215 17261582 17318181 18162579 18184650 19906994 20980834 21543332 22581055 26496610 27107012 28514442 30018425 31160578 details
CDT1_HUMANORC1_HUMANBioGRID, HPRD, IntAct15232106 details
CDT1_HUMANCDC5L_HUMANBioGRID, HPRD, IntAct15232106 details
CDT1_HUMANCDC6_HUMANBioGRID, HPRD, IntAct14672932 15232106 18162579 25990725 details
CDT1_HUMANORC2_HUMANBioGRID, HPRD, IntAct15232106 details
CDT1_HUMANSKP2_HUMANBioGRID, HPRD, IntAct12840033 14993212 15004027 15855168 18162579 26496610 31160578 details
CDT1_HUMANCDK2_HUMANBioGRID, HPRD, IntAct14993212 15004027 15855168 23455922 26496610 31160578 details
CDT1_HUMANCCNA2_HUMANBioGRID, HPRD, IntAct14993212 18184650 26186194 26496610 28514442 31160578 details
CDT1_HUMANCDK1_HUMANBioGRID, HPRD, IntAct14993212 26186194 28514442 31160578 details
CDT1_HUMANPCNA_HUMANBioGRID, HPRD, MINT16362051 16407242 16407252 16482215 16861906 18162579 21930785 24423875 26272819 30018425 30301766 30623174 details
CDT1_HUMANMCM6_HUMANBioGRID, HPRD, IntAct, UniProt12192004 18162579 18184650 20202939 21099365 22140117 26496610 details
CDT1_HUMANNDC80_HUMANDIP22581055 details
CDT1_HUMANCDC23_HUMANBioGRID18162579 details
CDT1_HUMANSMCA5_HUMANBioGRID18162579 21937426 details
CDT1_HUMANBAZ1B_HUMANBioGRID18162579 details
CDT1_HUMANMCM4_HUMANBioGRID18162579 details
CDT1_HUMANGRWD1_HUMANBioGRID18162579 25990725 details
CDT1_HUMANNPM_HUMANBioGRID18162579 details
CDT1_HUMANTOP1_HUMANBioGRID18162579 details
CDT1_HUMANAPC7_HUMANBioGRID18162579 details
CDT1_HUMANTOP2A_HUMANBioGRID18162579 details
CDT1_HUMANCDC20_HUMANBioGRID18162579 details
CDT1_HUMANFZR1_HUMANBioGRID18162579 details
CDT1_HUMANHDA11_HUMANBioGRID19276081 20980834 details
CDT1_HUMANKAT2B_HUMANBioGRID19276081 details
CDT1_HUMANEP300_HUMANBioGRID19276081 details
CDT1_HUMANKAT7_HUMANBioGRID18832067 20980834 details
CDT1_HUMANDDB1_HUMANBioGRID15448697 22451935 details
CDT1_HUMANFOXO3_HUMANBioGRID22451935 details
CDT1_HUMANCCNB1_HUMANBioGRID14993212 details
CDT1_HUMANDTL_HUMANBioGRID21930785 24906324 26272819 30623174 details
CDT1_HUMANFBX31_HUMANBioGRID24828503 details
CDT1_HUMANMK14_HUMANBioGRID21930785 details
CDT1_HUMANMCM2_HUMANBioGRID21930785 details
CDT1_HUMANCCNA1_HUMANBioGRID, IntAct14993212 15004027 15138268 31160578 details
CDT1_HUMANCUL1_HUMANBioGRID12840033 30018425 details
CDT1_HUMANAPC5_HUMANBioGRID18162579 details
CDT1_HUMANIMA1_HUMANBioGRID18162579 details
CDT1_HUMANIMB1_HUMANBioGRID18162579 details
CDT1_HUMANDDB2_HUMANBioGRID15448697 details
CDT1_HUMANCUL4A_HUMANBioGRID14578910 15448697 17079684 details
CDT1_HUMANCCNE1_HUMANBioGRID15004027 details
CDT1_HUMANCDK4_HUMANBioGRID15004027 details
CDT1_HUMANCUL4B_HUMANBioGRID14578910 details
CDT1_HUMANCSN5_HUMANBioGRID17079684 details
CDT1_HUMANMK09_HUMANBioGRID21930785 details
CDT1_HUMANFAF1_HUMANBioGRID26842564 details
CDT1_HUMANUBP37_HUMANBioGRID27296872 details
CDT1_HUMANMCM7_HUMANBioGRID25990725 details
CDT1_HUMANCDT1_HUMANBioGRID, HPRD14993212 31160578 details
CDT1_HUMANUBB_HUMANHPRD16407252 details