Entity Details

Primary name S12A5_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9H2X9
EntryNameS12A5_HUMAN
FullNameSolute carrier family 12 member 5
TaxID9606
Evidenceevidence at protein level
Length1139
SequenceStatuscomplete
DateCreated2002-12-13
DateModified2021-06-02

Ontological Relatives

GenesSLC12A5

GO terms

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GOName
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006811 ion transport
GO:0006873 cellular ion homeostasis
GO:0006884 cell volume homeostasis
GO:0006971 hypotonic response
GO:0007268 chemical synaptic transmission
GO:0007612 learning
GO:0015108 chloride transmembrane transporter activity
GO:0015379 potassium:chloride symporter activity
GO:0016021 integral component of membrane
GO:0019901 protein kinase binding
GO:0030644 cellular chloride ion homeostasis
GO:0035264 multicellular organism growth
GO:0040040 thermosensory behavior
GO:0042493 response to drug
GO:0043005 neuron projection
GO:0043025 neuronal cell body
GO:0045202 synapse
GO:0055064 chloride ion homeostasis
GO:0055075 potassium ion homeostasis
GO:0060996 dendritic spine development
GO:0071944 cell periphery
GO:1902476 chloride transmembrane transport
GO:1990573 potassium ion import across plasma membrane

Subcellular Location

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Subcellular Location
Membrane

Domains

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DomainNameCategoryType
IPR000076 K/Cl co-transporterFamilyFamily
IPR004841 Amino acid permease/ SLC12A domainDomainDomain
IPR004842 SLC12A transporter familyFamilyFamily
IPR018491 SLC12A transporter, C-terminalDomainDomain
IPR030358 K/Cl co-transporter 2FamilyFamily

Diseases

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Drugs

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DrugNameSourceType
DB00761 Potassium chlorideDrugbanksmall molecule
DB00887 BumetanideDrugbanksmall molecule

Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
S12A5_HUMANCCR4_HUMANBioGRID, MINT28298427 details
S12A5_HUMANPAR2_HUMANBioGRID, MINT28298427 details